Chemical Name: N-[(3R,4S)-3-[4-(5-cyano-2-thienyl)phenyl]tetrahydro-2H-pyran-4-yl]-2-propanesulfonamide
Biological ActivityPositive allosteric modulator of AMPA receptors (Ki = 85 nM). Prevents ketamine-induced working memory impairments. Brain penetrant.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Prevention of KA-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction.
Roberts et al.
Behav.Brain Res., 2010;212:41
An evaluation of using rat-derived single-dose neuropharmacokinetic parameters to project accurately large animal unbound brain drug concentrations.
Doran et al.
Drug Metab.Dispos., 2012;40:2162
Positive allosteric modulation of AMPA receptors from efficacy to toxicity: the interspecies exposure-response continuum of the novel potentiator PF-4778574.
Shaffer et al.
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