Phaclofen
Chemical Name: (RS)-3-Amino-2-(4-chlorophenyl)propylphosphonic acid
Purity: ≥97%
Biological Activity
Selective GABAB antagonist. Phosphono analog of GABAB agonist baclofen (Cat. No. 0417).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Phaclofen: a GABAB blocker reduced long-duration inhibition in the neocortex.
Karlsson et al.
Eur.J.Pharmacol., 1988;148:485 -
Comparison of antagonism by phaclofen of bac. induced hyperpolarization and synaptically mediated late hyperpolarizing potentials recorded intracellularly from rat dorsolateral septal neurons.
Hasuo and Gallagher
Neurosci.Lett., 1988;86:77 -
Phaclofen: a peripheral and central bac. antagonist.
Kerr et al.
Brain Res., 1987;405:150
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Citations for Phaclofen
The citations listed below are publications that use Tocris products. Selected citations for Phaclofen include:
3 Citations: Showing 1 - 3
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Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference.
Authors: Dulcis Et al.
Neuron 2017;95:1319
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The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.
Authors: Wood Et al.
Br J Pharmacol 2000;131:1050
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Effect of chronic ethanol treatment in vivo on excitability in mouse cortical neurones in vitro.
Authors: Ibbotson Et al.
Br J Pharmacol 1997;122:956
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