Catalog Number: 0178
Chemical Name: (RS)-3-Amino-2-(4-chlorophenyl)propylphosphonic acid
Biological Activity
Selective GABAB antagonist. Phosphono analog of GABAB agonist baclofen (Cat. No. 0417).
Technical Data
  • M.Wt:
    249.63
  • Formula:
    C9H13ClNO3P
  • Solubility:
    Soluble to 25 mM in 1eq. NaOH
  • Purity:
    >97%
  • Storage:
    Store at RT
  • CAS No:
    114012-12-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Phaclofen: a GABAB blocker reduced long-duration inhibition in the neocortex.
    Karlsson et al.
    Eur.J.Pharmacol., 1988;148:485
  2. Comparison of antagonism by phaclofen of baclofen induced hyperpolarization and synaptically mediated late hyperpolarizing potentials recorded intracellularly from rat dorsolateral septal neurons.
    Hasuo and Gallagher
    Neurosci.Lett., 1988;86:77
  3. Phaclofen: a peripheral and central baclofen antagonist.
    Kerr et al.
    Brain Res., 1987;405:150
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Phaclofen include:

1 Citations: Showing 1 - 1

  1. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.
    Authors: Wood Et al.
    Br J Pharmacol 2000;131:1050

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