Catalog Number: 0994
Chemical Name: 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
Biological Activity

5-HT1A/1B receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β3-adrenoceptors.

S-enantiomer also available.
Technical Data
  • M.Wt:
    248.32
  • Formula:
    C14H20N2O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    13523-86-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Structural and conformational features determining selective signal transduction in the β3-adrenergic receptor.
    Blin et al.
    Mol.Pharmacol., 1993;44:1094
  3. Electrophysiological and neurochemical evidence that pindolol has agonist properties at the 5-HT1A autoreceptor in vivo.
    Clifford et al.
    Br.J.Pharmacol., 1998;124:206
  4. Antagonist properties of (-)-pindolol and WAY 100635 at somatodendritic and postsynaptic 5-HT1A receptors in the rat brain.
    Corradetti et al.
    Br.J.Pharmacol., 1998;123:449
  5. VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin).
    Hoyer et al.
    Pharmacol.Rev., 1994;46:157
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Pindolol include:

3 Citations: Showing 1 - 3
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  1. β2-adrenoreceptor Inverse Agonist Down-regulates Muscarine Cholinergic Subtype-3 Receptor and Its Downstream Signal Pathways in Airway Smooth Muscle Cells in vitro.
    Authors: Luo
    Scientific Reports 2017;7:39905
  2. Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands.
    Authors: Littmann Et al.
    Front Microbiol 2015;355:183
  3. Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation.
    Authors: Kleinbongard Et al.
    Circ Res 2011;108:344
Tocris Small Molecules
Description Application Cat# Citations Images  

(S)-(-)-Pindolol

1060 1  
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