Chemical Name: 5,6-Dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-2(1H)-pyridinone
Biological ActivityPiperlongumine is an induces cell death and increases the level of reactive oxygen species (ROS) in cancer cells with both wild-type and normal p53. Also inhibits the growth of spontaneous malignant breast tumors in mice. Displays little effect on normal cells. Rapidly depletes androgen receptor expression in human prostate cancer cells via a ROS-dependent, proteasome-mediated mechanism.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Selective killing of cancer cells by a small molecule targeting the stress response to ROS.
Raj et al.
Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells.
Golovine et al.
Prostate [Epub ahead of print], 2012;
Citation for Piperlongumine
The citations listed below are publications that use Tocris products. Selected citations for Piperlongumine include:
1 Citation: Showing 1 - 1
An improved quantitative approach for the assessment of mitochondrial fragmentation in chemoresistant ovarian cancer cells.
Authors: Farrand Et al.
PLoS One 2013;8:e74008
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Piperlongumine
There are currently no reviews for this product. Be the first to review Piperlongumine and earn rewards!
Have you used Piperlongumine?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image