Induces cell death and increases the level of reactive oxygen species (ROS) in cancer cells with both wild-type and normal p53. Also inhibits the growth of spontaneous malignant breast tumors in mice. Displays little effect on normal cells. Rapidly depletes androgen receptor expression in human prostate cancer cells via a ROS-dependent, proteasome-mediated mechanism.
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Selective killing of cancer cells by a small molecule targeting the stress response to ROS.
Raj et al.
Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells.
Golovine et al.
Prostate [Epub ahead of print], 2012;
The citations listed below are publications that use Tocris products. Selected citations for Piperlongumine include:
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