Piperlongumine
Chemical Name: 5,6-Dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-2(1H)-pyridinone
Purity: ≥97%
Biological Activity
Piperlongumine is an induces cell death and increases the level of reactive oxygen species (ROS) in cancer cells with both wild-type and normal p53. Also inhibits the growth of spontaneous malignant breast tumors in mice. Displays little effect on normal cells. Rapidly depletes androgen receptor expression in human prostate cancer cells via a ROS-dependent, proteasome-mediated mechanism.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Selective killing of cancer cells by a small molecule targeting the stress response to ROS.
Raj et al.
Nature, 2011;475:231 -
Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells.
Golovine et al.
Prostate [Epub ahead of print], 2012;
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Citation for Piperlongumine
The citations listed below are publications that use Tocris products. Selected citations for Piperlongumine include:
1 Citation: Showing 1 - 1
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An improved quantitative approach for the assessment of mitochondrial fragmentation in chemoresistant ovarian cancer cells.
Authors: Farrand Et al.
PLoS One 2013;8:e74008
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