Pladienolide B

  ( 4 citations )    
Product Datasheet
Catalog Number:6070
Chemical Name:(4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one
Product Details
Citations (4)
Reviews
Biological Activity
mRNA splicing inhibitor; decreases splicing capacity up to 75% in vitro. Directly targets splicesome-associated 130 (SAP130), inhibits splicing factor 3B subunit (SF3B1) and impairs U2 small nuclear ribonucleoprotein (U2 snRNP) interaction with pre-mRNA. Arrests cell cycle in G1 and G2/M phases. Displays antitumor activity against gastric cancer cells (IC50 values are 1.6-4.9 nM). Cell permeable and active in vivo.
Technical Data
  • M.Wt:
    536.7
  • Formula:
    C30H48O8
  • Solubility:
    Soluble to 1 mg/ml in DMSO
  • Purity:
    >95
  • Storage:
    Store at -20°C
  • CAS No:
    445493-23-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Pladienolide B include:

4 Citations: Showing 1 - 4
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  1. Small molecule modulators of pre-mRNA splicing in cancer therapy.
    Authors: Salton Et al.
    Trends Mol.Med.  2016;22:28
  2. RNA splicing modulation selectively impairs leukemia stem cell maintenance in secondary human AML.
    Authors: Crews Et al.
    Cell stem cell  2016;19:599
  3. Short-circuiting RNA splicing.
    Authors: Disney Et al.
    Nat.Chem.Biol.  2008;4:723
  4. Splicing factor SF3b as a target of the antitumor natural product pladienolide.
    Authors: Kotake Et al.
    Nat.Chem.Biol.  2007;3:570

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