Chemical Name: (4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one
Biological ActivityPladienolide B is a mRNA splicing inhibitor that decreases splicing capacity up to 75% in vitro. Pladienolide B directly targets splicesome-associated 130 (SAP130), inhibits splicing factor 3B subunit (SF3B1) and impairs U2 small nuclear ribonucleoprotein (U2 snRNP) interaction with pre-mRNA. Pladienolide B arrests the cell cycle in G1 and G2/M phases and displays antitumor activity against gastric cancer cells (IC50 values are 1.6-4.9 nM). Cell permeable and active in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Splicing controls the ubiquitin response during DNA double-strand break repair.
Pederiva C, Bohm S, Julner A, Farnebo M.
Cell Death Differ.
Therapeutic targeting of splicing in cancer.
Lee et al.
Nature Medicine, 2016;22:976
High antitumor activity of pladienolide B and its derivative in gastric cancer.
Sato et al.
Cancer Sci., 2014;105:110
Citations for Pladienolide B
The citations listed below are publications that use Tocris products. Selected citations for Pladienolide B include:
4 Citations: Showing 1 - 4
Small molecule modulators of pre-mRNA splicing in cancer therapy.
Authors: Salton Et al.
Trends Mol.Med. 2016;22:28
RNA splicing modulation selectively impairs leukemia stem cell maintenance in secondary human AML.
Authors: Crews Et al.
Cell stem cell 2016;19:599
Short-circuiting RNA splicing.
Authors: Disney Et al.
Splicing factor SF3b as a target of the antitumor natural product pladienolide.
Authors: Kotake Et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Pladienolide B
There are currently no reviews for this product. Be the first to review Pladienolide B and earn rewards!
Have you used Pladienolide B?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image