Porcine IL-2 APC-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: IL-2

IL-2 is a 15-19 kDa secreted O-glycosylated polypeptide that belongs to the gamma _c -receptor utilizing family of molecules. It is a monomer that is expressed by a limited number of cell types, including CD4⁺ and CD8⁺ T cells, gamma δ T cells, eosinophils, endothelial cells, and B cells. Its local concentration, plus the stoichiometry of it receptor ( a two or three subunit complex) appears to determine what effects it has on its target cells. It is suggested to both induce NK and CD8⁺ T cell proliferation, and promote NK cell and CD8⁺ T cell effector activity. IL-2 also appears to drive CD4⁺ Fox P3^- thymocytes into mature FoxP3⁺ Tregs, and to direct the conversion of CD4⁺ T cells into induced Tregs. Finally, IL-2 induces gamma δ T cells to secrete IFN-gamma, and endothelial cells to upregulate endocytic activity. Mature porcine IL-2 shares 71% and 51% amino acid sequence identity with human and mouse IL-2, respectively.

Product Datasheets

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