Potent, subtype-selective estrogen receptor agonist (EC50
~ 200 pM); displays 410-fold selectivity for ERα
. Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-α and estrogen receptor-β: correlations with biological character and distinct differences among SRC coactivator family members.
Kraichely et al.
Characterization of the biological roles of the estrogen receptors, ERα and ERβ, in estrogen target tissues in vivo through the use of an ERα-selective ligand.
Harris et al.
Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-α-selective agonists.
Stauffer et al.
The citations listed below are publications that use Tocris products. Selected citations for PPT include:
Showing Results 1 - 10 of 59