PPT

  ( 72 citations )    
Product Datasheet
Catalog Number:1426
Chemical Name:4,4',4''-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol
Product Details
Citations (72)
Reviews
Biological Activity
Potent, subtype-selective estrogen receptor agonist (EC50 ~ 200 pM); displays 410-fold selectivity for ERα over ERβ. Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo.
Technical Data
  • M.Wt:
    386.45
  • Formula:
    C24H22N2O3
  • Solubility:
    Soluble to 5 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    263717-53-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for PPT include:

72 Citations: Showing 1 - 10
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  1. Pancreatic insulin content regulation by the estrogen receptor ER alpha.
    Authors: Alonso-Magdalena Et al.
    PLoS One  ;3:e2069
  2. Estrogen enhances mismatch repair by induction of MLH1 expression via estrogen receptor-β.
    Authors: Lu Et al.
    Oncotarget  2017;8:38767
  3. Estrogen receptor 1 (ESR1) regulates VEGFA in adipose tissue.
    Authors: Fatima
    Sci Rep  2017;7(1):16716
  4. Identification of Differential ER-Alpha Versus ER-Beta Mediated Activation of eNOS in Ovine Uterine Artery Endothelial Cells.
    Authors: Pastore Et al.
    Biol Reprod  2016;94:139
  5. Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function.
    Authors: Kleensang Et al.
    Sci Rep  2016;6:28994
  6. Estrogen replacement therapy-induced neuroprotection against brain ischemia-reperfusion injury involves the activation of astrocytes via estrogen receptor β.
    Authors: Ma Et al.
    Sci Rep  2016;6:21467
  7. Pharmacological activation of estrogen receptors-α and -β differentially modulates keratinocyte differentiation with functional impact on wound healing.
    Authors: Perželová Et al.
    Endocrinology  2016;37:42603
  8. Mechanisms by Which 17β-Estradiol (E2) Suppress Neuronal cox-2 Gene Expression.
    Authors: Stacey Et al.
    PLoS One  2016;11:e0161430
  9. Rapid modulation of synaptogenesis and spinogenesis by 17β-estradiol in primary cortical neurons.
    Authors: Sellers Et al.
    Front Cell Neurosci  2015;9:137
  10. Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB.
    Authors: Zeng Et al.
    J Exp Med  2015;75:2049
  11. Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat.
    Authors: Mazzuca Et al.
    J Pharmacol Exp Ther  2015;352:291
  12. Oestrogen receptors interact with the α-catalytic subunit of AMP-activated protein kinase.
    Authors: Lipovka Et al.
    Cancer Res  2015;35
  13. Biologic roles of estrogen receptor-β and insulin-like growth factor-2 in triple-negative breast cancer.
    Authors: Hamilton Et al.
    Biomed Res Int  2015;2015:925703
  14. Estrogen mediated expression of nucleophosmin 1 in human endometrial carcinoma clinical stages through estrogen receptor-α signaling.
    Authors: Zhou Et al.
    Int J Mol Med  2015;14:540
  15. Gender effect in experimental models of human medulloblastoma: does the estrogen receptor β signaling play a role?
    Authors: Ciucci Et al.
    J Natl Cancer Inst  2014;9:e101623
  16. Loss of estrogen-mediated immunoprotection underlies female gender bias in experimental Crohn's-like ileitis.
    Authors: Goodman Et al.
    PLoS One  2014;7:1255
  17. Rat uterine oxytocin receptor and estrogen receptor α and β mRNA levels are regulated by estrogen through multiple estrogen receptors.
    Authors: Murata Et al.
    PLoS One  2014;60:55
  18. Activation of a Gq-coupled membrane estrogen receptor rapidly attenuates α2-adrenoceptor-induced antinociception via an ERK I/II-dependent, non-genomic mechanism in the female rat.
    Authors: Nag and Mokha
    Am J Physiol Regul Integr Comp Physiol  2014;267:122
  19. Support of a bi-faceted role of estrogen receptor β (ERβ) in ERα-positive breast cancer cells.
    Authors: Jonsson Et al.
    Endocr Relat Cancer  2014;21:143
  20. Both GPER and membrane oestrogen receptor-α activation protect ventricular remodelling in 17β oestradiol-treated ovariectomized infarcted rats.
    Authors: Lee Et al.
    J Cell Mol Med  2014;18:2454
  21. Estrogen responsiveness of the TFIID subunit TAF4B in the normal mouse ovary and in ovarian tumors.
    Authors: Wardell Et al.
    Biol Reprod  2013;89:116
  22. The memory-enhancing effects of hippocampal estrogen receptor activation involve metabotropic glutamate receptor signaling.
    Authors: Boulware Et al.
    J Neuroendocrinol  2013;33:15184
  23. The membrane estrogen receptor ligand STX rapidly enhances GABAergic signaling in NPY/AgRP neurons: role in mediating the anorexigenic effects of 17β-estradiol.
    Authors: Smith Et al.
    Am J Physiol Endocrinol Metab  2013;305:E632
  24. The effect of estrogen compounds on human embryoid bodies.
    Authors: Kim Et al.
    Nucl Recept  2013;20:661
  25. Estrogen Induces Metastatic Potential of Papillary Thyroid Cancer Cells through Estrogen Receptor α and β.
    Authors: Dong Et al.
    Int J Endocrinol  2013;2013:941568
  26. Estradiol promotes the development of a fibrotic phenotype and is increased in the serum of patients with systemic sclerosis.
    Authors: Aida-Yasuoka Et al.
    Behav Brain Res  2013;15:R10
  27. The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer.
    Authors: Vinnedge Et al.
    Neuroscience  2012;7:e46985
  28. Estrogen modulates NFκB signaling by enhancing IκBα levels and blocking p65 binding at the promoters of inflammatory genes via estrogen receptor-β.
    Authors: Xing Et al.
    PLoS One  2012;7:e36890
  29. Estrogen prevents oxidative damage to the mitochondria in Friedreich's ataxia skin fibroblasts.
    Authors: Richardson Et al.
    Neuropsychopharmacology  2012;7:e34600
  30. Estrogen represses hepatocellular carcinoma (HCC) growth via inhibiting alternative activation of tumor-associated macrophages (TAMs).
    Authors: Yang Et al.
    J Biol Chem  2012;287:40140
  31. Estrogen-responsive nitroso-proteome in uterine artery endothelial cells: role of endothelial nitric oxide synthase and estrogen receptor-β.
    Authors: Zhang Et al.
    J Cell Physiol  2012;227:146
  32. Src Inhibition with saracatinib reverses fulvestrant resistance in ER-positive ovarian cancer models in vitro and in vivo.
    Authors: Simpkins Et al.
    Clin Cancer Res  2012;18:5911
  33. Estradiol increases cell growth in human astrocytoma cell lines through ERα activation and its interaction with SRC-1 and SRC-3 coactivators.
    Authors: González-Arenas Et al.
    Biochim Biophys Acta  2012;1823:379
  34. Estradiol directly attenuates sodium currents and depolarizing afterpotentials in isolated gonadotropin-releasing hormone neurons.
    Authors: Wang and Kuehl-Kovarik
    Brain Res  2012;1436:81
  35. Estradiol and progesterone strongly inhibit the innate immune response of mononuclear cells in newborns.
    Authors: Giannoni Et al.
    Infect Immun  2011;79:2690
  36. 17β-Estradiol enhances breast cancer cell motility and invasion via extra-nuclear activation of actin-binding protein ezrin.
    Authors: Zheng Et al.
    PLoS One  2011;6:e22439
  37. Specific activation of estrogen receptor α and β enhances male sexual behavior and neuroplasticity in male Japanese quail.
    Authors: Seredynski Et al.
    Endocrinology  2011;6:e18627
  38. Sex hormone control of left ventricular structure/function: mechanistic insights using echocardiography, expression, and DNA methylation analyses in adult mice.
    Authors: Sebag Et al.
    Am J Pathol  2011;301:H1706
  39. Oestrogen induces rhythmic expression of the Kisspeptin-1 receptor GPR54 in hypothalamic gonadotrophin-releasing hormone-secreting GT1-7 cells.
    Authors: Tonsfeldt Et al.
    PLoS One  2011;23:823
  40. The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects {β}-cells against stress-induced apoptosis.
    Authors: Baquié Et al.
    J Pharmacol Exp Ther  2011;20:2823
  41. Molecular mechanisms of bladder outlet obstruction in transgenic male mice overexpressing aromatase (Cyp19a1).
    Authors: Lin Et al.
    Mucosal Immunol  2011;178:1233
  42. Estradiol selectively stimulates endothelial prostacyclin production through estrogen receptor-{alpha}.
    Authors: Sobrino Et al.
    J Mol Endocrinol  2010;44:237
  43. Estradiol acutely potentiates hippocampal excitatory synaptic transmission through a presynaptic mechanism.
    Authors: Smejkalova and Woolley
    J Neurosci  2010;30:16137
  44. Estrogen stimulates degradation of β-amyloid peptide by up-regulating neprilysin.
    Authors: Liang Et al.
    Arthritis Res Ther  2010;285:935
  45. Estrogen promotes cutaneous wound healing via estrogen receptor β independent of its antiinflammatory activities.
    Authors: Campbell Et al.
    Mol Cell Endocrinol  2010;207:1825
  46. 17β-estradiol inhibits wound healing in male mice via estrogen receptor-α.
    Authors: Gilliver Et al.
    J Neurosci  2010;176:2707
  47. Neonatal bisphenol-a exposure alters rat reproductive development and ovarian morphology without impairing activation of gonadotropin-releasing hormone neurons.
    Authors: Adewale Et al.
    Biol Reprod  2009;81:690
  48. Clomiphene citrate causes aberrant tubal apoptosis and estrogen receptor activation in rat fallopian tube: implications for tubal ectopic pregnancy.
    Authors: Shao Et al.
    Biol Reprod  2009;80:1262
  49. Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair.
    Authors: Pedram Et al.
    Mol Biol Cell  2009;20:3374
  50. Neonatal agonism of ERα masculinizes serotonergic (5-HT) projections to the female rat ventromedial nucleus of the hypothalamus (VMN) but does not impair lordosis.
    Authors: Patisaul Et al.
    Hum Mol Genet  2009;196:317
  51. Estrogen receptor-beta agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress.
    Authors: Weiser Et al.
    Endocrinology  2009;150:1817
  52. Blockade of estrogen receptor signaling inhibits growth and migration of medulloblastoma.
    Authors: Belcher Et al.
    Endocrinology  2009;150:1112
  53. Different roles of estrogen receptors alpha and beta in the regulation of E-cadherin protein levels in a mouse mammary epithelial cell line.
    Authors: Helguero Et al.
    Cancer Res  2008;68:8695
  54. Mitochondrial effects of estrogen are mediated by estrogen receptor α in brain endothelial cells.
    Authors: Razmara Et al.
    Am J Physiol Heart Circ Physiol  2008;325:782
  55. Liquiritigenin is a plant-derived highly selective estrogen receptor β agonist.
    Authors: Mersereau Et al.
    J Biol Chem  2008;283:49
  56. Roles of estrogen receptor alpha and beta in modulating urothelial cell proliferation.
    Authors: Teng Et al.
    Endocr Relat Cancer  2008;15:351
  57. The novel estrogen receptor, G protein-coupled receptor 30, mediates the proliferative effects induced by 17β-estradiol on mouse spermatogonial GC-1 cell line.
    Authors: Sirianni Et al.
    Biosci Rep  2008;149:5043
  58. An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo.
    Authors: Sinkevicius Et al.
    Endocrinology  2008;149:2970
  59. Estrogen receptor beta protects against acoustic trauma in mice.
    Authors: Meltser Et al.
    J Clin Invest  2008;118:1563
  60. Influence of cellular ERalpha/ERbeta ratio on the ERalpha-agonist induced proliferation of human T47D breast cancer cells.
    Authors: Sotoca Et al.
    Toxicol Sci  2008;105:303
  61. Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer.
    Authors: Setlur Et al.
    Horm Behav  2008;100:815
  62. Evidence for the involvement of ERβ and RGS9-2 in 17-β estradiol enhancement of amphetamine-induced place preference behavior.
    Authors: Silverman and Koenig
    PLoS One  2007;52:146
  63. NM23-H2, an estrogen receptor β-associated protein, shows diminished expression with progression of atherosclerosis.
    Authors: Rayner Et al.
    Reprod Sci  2007;292:R743
  64. 17beta-Estradiol utilizes the estrogen receptor to regulate CD16 expression in monocytes.
    Authors: Kramer Et al.
    Mol Cell Endocrinol  2007;279:16
  65. Studies on estrogen receptor (ER) alpha and beta responses on gene regulation in peripheral blood leukocytes in vivo using selective ER agonists.
    Authors: Stygar Et al.
    J Endocrinol  2007;194:101
  66. Tissue- and hormone-dependent progesterone receptor distribution in the rat uterus.
    Authors: Sahlin Et al.
    Reprod Biol Endocrinol  2006;4:47
  67. 17β-estradiol induces apoptosis in the developing rodent prostate independently of ERα or ERβ.
    Authors: Taylor Et al.
    Am J Pathol  2006;147:191
  68. Estrogen receptor alpha pathway is involved in the regulation of Calbindin-D9k in the uterus of immature rats.
    Authors: Lee Et al.
    Toxicol Sci  2005;84:270
  69. Stimulatory cross-talk between NFAT3 and estrogen receptor in breast cancer cells.
    Authors: Zhang Et al.
    J Biol Chem  2005;280:43188
  70. Estrogen modulates endothelial and neuronal nitric oxide synthase expression via an estrogen receptor beta-dependent mechanism in hypothalamic slice cultures.
    Authors: Gingerich and Krukoff
    Endocrinology  2005;146:2933
  71. Estrogen receptor-alpha mediates gene expression changes and growth response in ovarian cancer cells exposed to estrogen.
    Authors: O'Donnell Et al.
    Endocr Relat Cancer  2005;12:851
  72. Estrogen receptor-dependent activation of AP-1 via non-genomic signalling.
    Authors: Björnström and Sjöberg
    Cancer Cell Int  2004;2:3
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