PQ 69

Catalog # Availability Size / Price Qty
5351/10
5351/50
Cat.No. 5351 - PQ 69 | C20H19FN4O | CAS No. 910045-32-8
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Description: Potent and selective A1 inverse agonist

Chemical Name: 4-(Butylamino)-2-(3-fluorophenyl)-1,2-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one

Purity: ≥98%

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Biological Activity

Potent and selective A1 receptor inverse agonist. Exhibits high binding affinity at A1 receptor (Ki values are 0.07 and 0.96 nM for rat and human receptors respectively). Reduces basal [35S]-GTPγS binding 44.6% (IC50 = 0.19 nM). Antagonizes the effects of A1 agonist R-PIA (IC50 = 18.3 nM) and exhibits competitive antagonism on CCPA-induced tracheal contractions ex vivo. Displays 217- fold selectively over hA2A receptor and >1000-fold selectivity over hA3 receptor.

Technical Data

M.Wt:
350.39
Formula:
C20H19FN4O
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
910045-32-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. PQ-69, a novel and selective adenosine A1 receptor antagonist with inverse agonist activity.
    Lu et al.
    Purinergic Signal., 2014;10:619

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