Pregabalin

Catalog # Availability Size / Price Qty
3775/10
3775/50
Additional Voltage-gated Calcium Channel Compounds Small Molecule
1 Image
Description: Anticonvulsant; selectively binds the α2δ subunit of voltage-sensitive calcium channels

Chemical Name: (S)-3-(Aminomethyl)-5-methylhexanoic acid

Product Details
Reviews

Biological Activity

Anticonvulsant and antiepileptic; also used to treat neuropathic pain. Binds with high affinity and selectivity to the α2δ subunit of voltage-sensitive Ca2+ channels and modulates their activity. Displays anxiolytic-like activity in ethological and conflict models of anxiety. Analog of GABA (Cat. No. 0344).

Technical Data

M.Wt:
159.23
Formula:
C8H17NO2
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
148553-50-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity.
    Field et al.
    Br.J.Pharmacol., 2001;132:1
  2. Pregabalin in the management of partial epilepsy.
    Arain
    Neuropsych.Dis.Treat., 2009;5:407
  3. Evidence that prega. reduces neuropathic pain by inhibiting the spinal release of glutamate.
    Kumar et al.
    J.Neurochem., 2010;113:552

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