Catalog Number: 3775
Chemical Name: (S)-3-(Aminomethyl)-5-methylhexanoic acid
Biological Activity
Anticonvulsant and antiepileptic; also used to treat neuropathic pain. Binds with high affinity and selectivity to the α2δ subunit of voltage-sensitive Ca2+ channels and modulates their activity. Displays anxiolytic-like activity in ethological and conflict models of anxiety. Analog of GABA (Cat. No. 0344).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity.
    Field et al.
    Br.J.Pharmacol., 2001;132:1
  2. Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate.
    Kumar et al.
    J.Neurochem., 2010;113:552
  3. Pregabalin in the management of partial epilepsy.
    Neuropsych.Dis.Treat., 2009;5:407
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