Chemical Name: (S)-3-(Aminomethyl)-5-methylhexanoic acid
Biological ActivityAnticonvulsant and antiepileptic; also used to treat neuropathic pain. Binds with high affinity and selectivity to the α2δ subunit of voltage-sensitive Ca2+ channels and modulates their activity. Displays anxiolytic-like activity in ethological and conflict models of anxiety. Analog of GABA (Cat. No. 0344).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity.
Field et al.
Pregabalin in the management of partial epilepsy.
Evidence that prega. reduces neuropathic pain by inhibiting the spinal release of glutamate.
Kumar et al.
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