Chemical Name: (S)-3-(Aminomethyl)-5-methylhexanoic acid
Biological ActivityAnticonvulsant and antiepileptic; also used to treat neuropathic pain. Binds with high affinity and selectivity to the α2δ subunit of voltage-sensitive Ca2+ channels and modulates their activity. Displays anxiolytic-like activity in ethological and conflict models of anxiety. Analog of GABA (Cat. No. 0344).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity.
Field et al.
Pregabalin in the management of partial epilepsy.
Evidence that prega. reduces neuropathic pain by inhibiting the spinal release of glutamate.
Kumar et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Pregabalin
Average Rating: 5 (Based on 1 Review)
Have you used Pregabalin?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Pregabalin was observed to understand its production of dose-dependent increase in the brain expression of L-glutamic acid decarboxylase (GAD), the enzyme responsible for synthesizing GABA, and hence how it may have some indirect GABAergic effects by increasing GABA levels in the brain.