Pregabalin | CAS No. 148553-50-8 | Additional Voltage-gated Calcium Channel Compounds
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Description: Anticonvulsant; selectively binds the α2δ subunit of voltage-sensitive calcium channels

Chemical Name: (S)-3-(Aminomethyl)-5-methylhexanoic acid

Product Details
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Biological Activity

Anticonvulsant and antiepileptic; also used to treat neuropathic pain. Binds with high affinity and selectivity to the α2δ subunit of voltage-sensitive Ca2+ channels and modulates their activity. Displays anxiolytic-like activity in ethological and conflict models of anxiety. Analog of GABA (Cat. No. 0344).

Technical Data

Soluble to 100 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity.
    Field et al.
    Br.J.Pharmacol., 2001;132:1
  2. Pregabalin in the management of partial epilepsy.
    Neuropsych.Dis.Treat., 2009;5:407
  3. Evidence that prega. reduces neuropathic pain by inhibiting the spinal release of glutamate.
    Kumar et al.
    J.Neurochem., 2010;113:552

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Pregabalin was observed to understand its production of dose-dependent increase in the brain expression of L-GAD
By Anonymous on 12/26/2019
Application: Species: Human

Pregabalin was observed to understand its production of dose-dependent increase in the brain expression of L-glutamic acid decarboxylase (GAD), the enzyme responsible for synthesizing GABA, and hence how it may have some indirect GABAergic effects by increasing GABA levels in the brain.

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