Anticonvulsant and antiepileptic; also used to treat neuropathic pain. Binds with high affinity and selectivity to the α2δ
subunit of voltage-sensitive Ca2+
channels and modulates their activity. Displays anxiolytic-like activity in ethological and conflict models of anxiety. Analog of GABA
(Cat. No. 0344).
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Sold for research purposes under agreement from Pfizer Inc.
Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity.
Field et al.
Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate.
Kumar et al.
Pregabalin in the management of partial epilepsy.