Chemical Name: (1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one
Biological ActivityPKC activator. Inhibits growth and induces differentiation of AML cell lines. Enhances cytarabine-induced differentiation of AML cells. Inhibits tumorigenesis in KRAS mutant pancreatic cancer cells and reduces tumor growth in mouse pancreatic tumor models. Also NF-κB activator. Activates HIV gene expression in T cells. Orally available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents.
Shen et al.
Cancer Lett., 2015;356:686
K-Ras promotes tumorigenicity through suppression of non-canonical Wnt signaling.
Wang et al.
Protein kinase D3 is essential for prostratin-activated transcription of integrated HIV-1 provirus promoter via NF-κB signaling pathway.
Wang et al.
BioMed Res.Int., 2014;2014:968027
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