Proteome Purify 12 Human Serum Protein Immunodepletion Resin

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Citations (8)
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Proteome Purify 12 Human Serum Protein Immunodepletion Resin Summary

The wide dynamic range of protein concentrations present in serum and plasma represents a major challenge for the analysis of the proteome. The range of plasma protein concentrations, from low abundance proteins such as cytokines (pg/mL) to albumin (30-45 mg/mL), represents at least 10 orders of magnitude. Analysis of low abundance proteins by even the most sensitive of methods for proteomics greatly benefits from the removal of high abundance proteins that may interfere with their detection.

The Proteome Purify™ 12 Human Serum Protein Immunodepletion Resin is designed as a single-use alternative to existing column or spin cartridge systems. The single-use resin allows researchers to economically deplete 20 or 40 serum or plasma samples of the 12 high abundance proteins that make up approximately 95% of all proteins found in human serum or plasma. This resin will process 10 microliters of serum or plasma per tests.

The Proteome Purify 12 Human Serum Protein Immunodepletion Resin is designed to effectively deplete serum or plasma samples of the following 12 high abundance proteins:

  • alpha 1-Acid Glycoprotein
  • alpha 1-Antitrypsin
  • alpha 2-Macroglobulin
  • Albumin
  • Apolipoprotein A-I
  • Apolipoprotein A-II
  • Fibrinogen
  • Haptoglobin
  • IgA
  • IgG
  • IgM
  • Transferrin

Kit Contents

  • Immunodepletion Resin
  • 4 Spin-X Filter Units


Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

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Citations for Proteome Purify 12 Human Serum Protein Immunodepletion Resin

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

8 Citations: Showing 1 - 8
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  1. Towards identification of novel putative biomarkers for infective endocarditis by serum proteomic analysis
    Authors: MG Snipsøyr, H Wiggers, M Ludvigsen, A Stensballe, H Vorum, SH Poulsen, LM Rasmussen, E Petersen, B Honoré
    Int. J. Infect. Dis., 2020-02-19;0(0):.  2020-02-19
  2. Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment
    Authors: D Guha, DR Lorenz, V Misra, S Chettimada, S Morgello, D Gabuzda
    J Neuroinflammation, 2019-12-05;16(1):254.  2019-12-05
  3. Exosome markers associated with immune activation and oxidative stress in HIV patients on antiretroviral therapy
    Authors: S Chettimada, DR Lorenz, V Misra, ST Dillon, RK Reeves, C Manickam, S Morgello, GD Kirk, SH Mehta, D Gabuzda
    Sci Rep, 2018-05-08;8(1):7227.  2018-05-08
  4. Proteome and Metabolome of Subretinal Fluid in Central Serous Chorioretinopathy and Rhegmatogenous Retinal Detachment: A Pilot Case Study
    Authors: L Kowalczuk, A Matet, M Dor, N Bararpour, A Daruich, A Dirani, F Behar-Cohe, A Thomas, N Turck
    Transl Vis Sci Technol, 2018-01-18;7(1):3.  2018-01-18
  5. Evidence of Altered Glycosylation of Serum Proteins Prior to Pancreatic Cancer Diagnosis
    Authors: S Krishnan, HJ Whitwell, J Cuenco, A Gentry-Mah, U Menon, SP Pereira, M Gaspari, JF Timms
    Int J Mol Sci, 2017-12-09;18(12):.  2017-12-09
  6. Novel panel of protein biomarkers to predict response to bortezomib-containing induction regimens in multiple myeloma patients
    Authors: KR Ting, M Henry, J Meiller, A Larkin, M Clynes, P Meleady, D Bazou, P Dowling, P O'Gorman
    BBA Clin, 2017-06-07;8(0):28-34.  2017-06-07
  7. A novel core fucose-specific lectin from the mushroom Pholiota squarrosa.
    Authors: Kobayashi Y, Tateno H, Dohra H, Moriwaki K, Miyoshi E, Hirabayashi J, Kawagishi H
    J Biol Chem, 2012-08-07;287(41):33973-82.  2012-08-07
  8. Plasma biomarkers for detecting Hodgkin's lymphoma in HIV patients.
    Authors: Varnum SM, Webb-Robertson BJ, Hessol NA, Smith RD, Zangar RC
    PLoS ONE, 2011-12-15;6(12):e29263.  2011-12-15


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