Catalog Number: 2715
Alternate Names: 3-Phenacyl UDP disodium salt
Chemical Name: 3-(2-Oxo-2-phenylethyl)-uridine-5'-diphosphate disodium salt
Biological Activity
Potent and selective P2Y6 receptor agonist (EC50 values are 70, > 1000 and > 10000 nM for P2Y6, P2Y2 and P2Y4 receptors respectively). Induces contractions of rat isolated intrapulmonary arteries in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble in water (supplied pre-dissolved at a concentration of 10mM)
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4 and P2Y6 receptors.
    El-Tayeb et al.
    J.Med.Chem., 2006;49:7076
  2. Identification of contractile P2Y1, P2Y6, and P2Y12 receptors in rat intrapulmonary artery using selective ligands.
    Mitchell et al.
    J.Pharmacol.Exp.Ther., 2012;343:755

The citations listed below are publications that use Tocris products. Selected citations for PSB 0474 include:

Showing Results 1 - 4 of 4

  1. Microglia P2Y6 receptors mediate nitric oxide release and astrocyte apoptosis.
    Authors: Quintas Et al.
    J Neuroinflammation
  2. Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells.
    Authors: Barragán-Iglesias Et al.
    Mol Pain
  3. The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells.
    Authors: Gao Et al.
    Exp Eye Res
  4. Involvement of vasodilator-stimulated phosphoprotein in UDP-induced microglial actin aggregation via PKC- and Rho-dependent pathways.
    Authors: Kataoka Et al.
    Purinergic Signal
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