Catalog Number: 1580
Alternate Names: NG 60
Chemical Name: (2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
Biological Activity
Cyclin-dependent kinase inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Reversibly arrests synchronised cells in G1 and G2, and inhibits cell proliferation and cell death.
Technical Data
  • M.Wt:
    388.9
  • Formula:
    C19H25ClN6O
  • Solubility:
    Soluble to 50 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    212844-53-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from the Regents of the University of California
Background References
  1. The specificities of protein kinase inhibitors: an update.
    Bain et al.
    Biochem.J., 2003;371:199
  2. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.
    Gray et al.
    Science, 1998;281:533
  3. ATP-site directed inhibitors of cyclin-dependent kinases.
    Gray et al.
    Curr.Med.Chem., 1999;6:859
  4. Cellular effects of purvalanol A: a specific inhibitor of cyclin-dependent kinase activities.
    Villerbu et al.
    Int.J.Cancer, 2002;97:761
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Purvalanol A include:

3 Citations: Showing 1 - 3
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  1. Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition.
    Authors: Ozlü Et al.
    Mol Cell Proteomics 2010;9:336
  2. Compounds that target host cell proteins prevent varicella-zoster virus replication in culture, ex vivo, and in SCID-Hu mice.
    Authors: Rowe Et al.
    Antiviral Res 2010;86:276
  3. Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation.
    Authors: Pennati Et al.
    Mol Cancer Ther 2005;4:1328

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