RAIDD/CRADD Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-77048

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all CRADD Primary Antibodies »

Product Specifications

Immunogen

Antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human RAIDD. The immunogen is located within the last 50 amino acids of RAIDD. Amino Acid Squence: HNGLRAVEVDPSLLLHMLE

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

18 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for RAIDD/CRADD Antibody - BSA Free

Western Blot: RAIDD/CRADD AntibodyBSA Free [NBP1-77048]

Western Blot: RAIDD/CRADD AntibodyBSA Free [NBP1-77048]

Western Blot: RAIDD/CRADD Antibody [NBP1-77048] - Analysis of RAIDD in MCF7 total cell lysate with RAIDD antibody at 2 ug/mL.
Western Blot: RAIDD/CRADD AntibodyBSA Free [NBP1-77048]

Western Blot: RAIDD/CRADD AntibodyBSA Free [NBP1-77048]

Western Blot: RAIDD/CRADD Antibody [NBP1-77048] - HeLa total cell lysate with RAIDD antibody at 1 ug/ml.
RAIDD/CRADD Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: RAIDD/CRADD Antibody - BSA Free [NBP1-77048] -

Immunocytochemistry/ Immunofluorescence: RAIDD/CRADD Antibody - BSA Free [NBP1-77048] - Immunocytochemistry of RAIDD/CRADD in Hela cells with RAIDD/CRADD antibody at 10 ug/mL.
RAIDD/CRADD Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: RAIDD/CRADD Antibody - BSA Free [NBP1-77048] -

Immunocytochemistry/ Immunofluorescence: RAIDD/CRADD Antibody - BSA Free [NBP1-77048] - Immunofluorescence of RAIDD/CRADD in Hela cells with RAIDD/CRADD antibody at 20 ug/mL.

Green: RAIDD/CRADD Antibody
Blue: DAPI staining
RAIDD/CRADD Antibody - BSA Free

Immunohistochemistry: RAIDD/CRADD Antibody - BSA Free [NBP1-77048] -

Immunohistochemistry: RAIDD/CRADD Antibody - BSA Free [NBP1-77048] - Immunohistochemistry of RAIDD/CRADD in human kidney tissue with RAIDD/CRADD antibody at 10 ug/mL.

Applications for RAIDD/CRADD Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

5 ug/mL

Immunohistochemistry

10 ug/ml

Immunohistochemistry-Paraffin

10 ug/ml

Western Blot

2 ug/ml
Application Notes
A 22 kDa band should be detected in Western Blot.

Formulation, Preparation, and Storage

Purification

Ion exchange chromatography

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CRADD

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain (DD)-containing receptors, TNFR1 and Fas. The death signals are transduced by a group of DD-containing adapter molecules. A novel cell death adapter was recently identified by two independent groups and designated RAIDD (RIP-associated ICH-1/CED-3-homologous protein with DD) and CRADD (caspase and RIP adapter with DD)1,RAIDD contains a DD and a CARD (for caspase recruitment domain) which interact with RIP and caspase, respectively, to transduce death signals. RAIDD is constitutively expressed in many tissues and mediates apoptosis caused by Fas and TNFR-1.

Long Name

CASP2 and RIPK1 Domain Containing Adaptor With Death Domain

Alternate Names

RAIDD

Gene Symbol

CRADD

UniProt

AAB42217 (Human)

Additional CRADD Products

Product Documents for RAIDD/CRADD Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for RAIDD/CRADD Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Apoptosis Adaptor Proteins

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Protocols

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FAQs

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Associated Pathways

Apoptosis Signaling Pathway Apoptosis Signaling Pathway Thumbnail