Recombinant Human Calcium-sensing R/CaSR Protein, CF

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Recombinant Human Calcium-sensing R/CaSR Protein, CF Summary

Product Specifications

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Bioassay data are not available.
Human embryonic kidney cell, HEK293-derived human Calcium-sensing R/CaSR protein
Tyr20-Lys601, with a C-terminal 6-His tag
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
66 kDa
90-110 kDa, reducing conditions

Product Datasheets

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Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 250 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
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Background: Calcium-sensing R/CaSR

Calcium-sensing receptor (CasR) is a plasma membrane G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (1). CasR is expressed in the parathyroid hormone-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule (2). Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism (3). The full length of CasR has a large extracellular N-terminal domain, a central region of 7 transmembrane domains, and a long intracellular C‑terminal domain. The amino acid 20-601 contains the extracellular domain with multiple glycosylation sites (4). Human CasR shares 96.1% and 96.5% aa sequence identity with mouse and rat CasR, respectively.

  1. Geng, Y. et al. (2016) Elife 5:e13662.
  2. Hendy, G. N. et al. (2000) Hum. Mutat. 16:281.
  3. Brown, E. M. et al. (1993) Nature 366:575.
  4. Garrett, J. al. (1995) J. Biol. Chem. 270:12919.
Long Name
Calcium-sensing Receptor
Entrez Gene IDs
846 (Human); 12374 (Mouse); 24247 (Rat)
Alternate Names
calcium-sensing receptor; CAR; CaSR; EIG8; extracellular calcium-sensing receptor; FHH; FIH; GPRC2A; GPRC2AHHC; HHC1; hypocalciuric hypercalcemia 1; NSHPT; parathyroid Ca(2+)-sensing receptor 1; Parathyroid cell calcium-sensing receptor; PCaR1; PCAR1MGC138441


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