Recombinant Human CD151 Fc Chimera Protein, CF Summary
Accession # P48509
When Recombinant Human Integrin alpha V beta 3 (Catalog # 3050-AV) isimmobilized at 1 μg/mL, 100 μL/well, Recombinant Human CD151 Fc Chimera bindswith an ED50 of 0.3‑1.8 μg/mL.
2 μg/lane of Recombinant Human CD11b/Integrin alpha M was resolved with SDS-PAGE underreducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Bluestaining, showing bands at 41-55 kDa and 80 - 110 kDa, respectively.
Human CD151, also known as SFA-1, Tetraspanin-24, and GP27, is a palmitoylated glycoprotein in the tetraspanin superfamily. It is the first tetraspanin member to be identified as a promoter of cancer metastasis (1, 2), and it is found to participate in nearly all stages of cancer progression (3). CD-151 is normally expressed in endothelial cells, platelets, and frequently over-expressed in cancer cells (4). Mature CD-151 is a multi-pass membrane protein that contains four transmembrane domains, three cytoplasmic domains, and two extracellular loops. The region of amino acids (aa) 113-221 contains the largest extracellular loop (LEL) that involves in interacting with integrins and regulating integrin functions (5). Human CD151 LEL shares 88.9% and 87.0% aa identity with that of mouse and rat respectively. CD151 interacts with integrins such as alpha v beta 3, alpha 3 beta 1, alpha 6 beta 1, alpha 7 beta 1, and alpha 6 beta 4 to regulate their activities and thus resulting in modulation of adhesion, spreading, migration, angiogenesis, invasion and metastasis (1, 3-5). CD151 can also complex with immunoglobulin super family proteins and other tetraspanins such as CD9, CD81, and CD63 (3). Clinically, high levels of CD151 are correlated with poor prognosis in a variety of tumors (3, 4). CD151 has been implicated as a potential diagnostic marker in osteosarcoma and prostate cancer and a putative target for antibody-based immunotherapy (3). CD-151 is a key player in the formation of basement membranes in kidney and skin tissues; it is also associated with human papillomavirus (HPV) infection (6, 7).
- Detchokul, S. et al. (2014) Br. J. Pharmacol. 171(24):5462.
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- Sadej, R. et al. (2014) Laboratory Investigation 94:41.
- Kumari, S. et al. (2015) Biomark Cancer 7:7.
- Yu J. et al. (2017) Biochem. J. 474(4):589.
- Scheffer, K.D. et al. (2014) Viruses 6:893.
- Karamatic Crew, V. et al. (2004) Blood 104:2217.
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