Recombinant Human CTRP2/C1qTNF2 Induces Phosphorylation of AMPK in C2C12 Differentiated Myocytes. C2C12 differentiated myocytes were treated with Recombinant Human CTRP2/C1qTNF2 (Catalog # 9436‑TN) for 1 hour prior to Western blot analysis.
Complement C1q tumor necrosis factor-related protein 2 (C1qTNF2), also known as CTRP-2 or
zacrp2 is an approximately 30 kDa member of the C1q family of secreted proteins
(1, 2). Like other members of that family, CTRP2 contains a collagen-like
region and one C1q-like domain (3). CTRP2 shares 42% amino acids identity with
adiponectin at the presumed functional globular domain (4) and is expressed in stromal
vascular cells (5). CTRP2 circulates as
a trimeric glycoprotein in plasma (6), and can also form homo-oligomer or
hetero-oligomer with other CTRPs (7).
C1qTNF2 has been shown to phosphorylate AMPK and ACC in skeletal muscle
leading to an increase in glycogen accumulation and fatty acid oxidation
(8). C1qTNFs are of clinical interest as
diagnostic or therapeutic targets in diseases where energy homeostasis is
unbalanced such as obesity, insulin resistance, and type 2 diabetes (2).
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Seldin, MM. et al. (2014) Rev. Endocr. Metab. Disord. 15:111.
Kim, K.-Y et al. (2006) FEBS Lett. 580:3953.
Wong, GW et al. (2004). Proc. Natl. Acad. Sci. U.S.A. 101:10302.
Schäffler A. et al. (2012) Trends in Endocrinology and Metabolism. 23:194.
Wong, GW et al. (2008). Biochem J. 416:161.
Peterson, JMl, et al. (2014). PLOS one 9:e88535.
Schäffler A. et al. 2007) Trends in Immunology 28:393.
C1q And Tumor Necrosis Factor Related Protein 2
Entrez Gene IDs:
114898 (Human); 69183 (Mouse); 497886 (Rat)
C1q and tumor necrosis factor related protein 2; C1QTNF2; complement-c1q tumor necrosis factor-related protein 2; CTRP2; CTRP2complement C1q tumor necrosis factor-related protein 2; zacrp2
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