Recombinant Human GDNF Protein

Formulations:
Catalog # Availability Size / Price Qty
212-GD-010
212-GD-050
212-GD-01M
Recombinant Human GDNF Protein Bioactivity
2 Images
Product Details
Citations (73)
FAQs
Supplemental Products
Reviews (3)

Recombinant Human GDNF Protein Summary

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using SH‑SY5Y human neuroblastoma cells. The ED50 for this effect is 2‑12 ng/mL in the presence of Recombinant Human GFR alpha ‑1/GDNF R alpha ‑1 Fc Chimera (Catalog # 714‑GR).
The specific activity of recombinant human GDNF is approximately 3.1 x 103 units/μg, which is calibrated against recombinant human GDNF Reference Standard (NIBSC code: 09/266). Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human GFR alpha ‑1/GDNF R alpha ‑1 Fc Chimera (Catalog # 714-GR) at 1 µg/mL can bind Recombinant Human GDNF with an apparent K<1 nM.
Source
Mouse myeloma cell line, NS0-derived human GDNF protein
Arg109-Ile211
Accession #
N-terminal Sequence
Analysis
Arg109
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
11.6 kDa (monomer)

Product Datasheets

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

212-GD

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

212-GD/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Data Images

Bioactivity Recombinant Human GDNF Protein Bioactivity View Larger

Recombinant Human GDNF (Catalog # 212‑GD) induces SH-SY5Yhuman neuroblastoma cell proliferation in the presence of RecombinantHuman GFR alpha ‑1 Fc Chimera (Catalog # 714‑GR). The ED50 for this effectis 2‑12 ng/mL. The ED50 for the competitors is more than 85 ng/mL, which ismore than 20‑folder weaker.

SDS-PAGE Recombinant Human GDNF Protein SDS-PAGE View Larger

1 ug/lane of Recombinant Human GDNF was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing single bands at 17 kDa and 34 kDa, respectively.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: GDNF

Glial Cell Line-derived Neurotrophic Factor (GDNF) is a neurotrophic factor that has been shown to promote the survival of various neuronal subpopulations in both the central as well as the peripheral nervous systems at different stages of their development. Neuronal subpopulations that have been shown to be affected by GDNF include motoneurons, midbrain dopaminergic neurons, Purkinje cells and sympathetic neurons.

Native GDNF, a disulfide-linked homodimeric glycoprotein, is a novel member of the TGF-beta  superfamily. Human GDNF cDNA encodes a 211 amino acid residue prepropeptide that is processed to yield a dimeric protein. Mature human GDNF was predicted to contain two 134 amino acid residue subunits. NS0 expressed mature human GDNF lacks 31 residues from the amino-terminus of the predicted sequence. This glycosylated recombinant mature human GDNF still contains the seven conserved Cys residues found in all members of the TGF-beta superfamily and is biologically active. The GDNF sequence contains two potential glycosylation sites and insect cell‑expressed recombinant rat GDNF proteins are glycosylated. Mature rat and human GDNF exhibit approximately 93% amino acid sequence identity and show considerable species cross-reactivity. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells.

Long Name
Glial Cell line-derived Growth Factor
Entrez Gene IDs
2668 (Human); 25453 (Rat)
Alternate Names
Astrocyte-derived trophic factor; ATF; ATF1; ATF2; GDNF; glial cell derived neurotrophic factor; glial cell line derived neurotrophic factor; glial cell line-derived neurotrophic factor; HFB1-GDNF; hGDNF; HSCR3

Citations for Recombinant Human GDNF Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

73 Citations: Showing 1 - 10
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  1. Germline DNA replication timing shapes mammalian genome composition
    Authors: Y Yehuda, B Blumenfeld, N Mayorek, K Makedonski, O Vardi, L Cohen-Dani, Y Mansour, S Baror-Sebb, H Masika, M Farago, M Berger, S Carmi, Y Buganim, A Koren, I Simon
    Nucleic Acids Res., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Conserved and non-conserved characteristics of porcine glial cell line-derived neurotrophic factor expressed in the testis
    Authors: K Kakiuchi, K Taniguchi, H Kubota
    Sci Rep, 2018;8(1):7656.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients
    Authors: S Koyuncu, I Saez, HJ Lee, R Gutierrez-, W Pokrzywa, A Fatima, T Hoppe, D Vilchez
    Nat Commun, 2018;9(1):2886.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model
    Authors: N Tsuburaya, K Homma, T Higuchi, A Balia, H Yamakoshi, N Shibata, S Nakamura, H Nakagawa, SI Ikeda, N Umezawa, N Kato, S Yokoshima, M Shibuya, M Shimonishi, H Kojima, T Okabe, T Nagano, I Naguro, K Imamura, H Inoue, T Fujisawa, H Ichijo
    Nat Commun, 2018;9(1):2668.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Streamlined circular proximity ligation assay provides high stringency and compatibility with low-affinity antibodies
    Authors: R Jalili, J Horecka, JR Swartz, RW Davis, HHJ Persson
    Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):.
    Applications: Bioassay
  6. Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology
    Authors: MJ Ziller, JA Ortega, KA Quinlan, DP Santos, H Gu, EJ Martin, C Galonska, R Pop, S Maidl, A Di Pardo, M Huang, HY Meltzer, A Gnirke, CJ Heckman, A Meissner, E Kiskinis
    Cell Stem Cell, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons
    Authors: G Collo, L Cavalleri, M Zoli, U Maskos, E Ratti, E Merlo Pich
    Front Pharmacol, 2018;9(0):572.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission
    Authors: R Nehme, E Zuccaro, SD Ghosh, C Li, JL Sherwood, O Pietilaine, LE Barrett, F Limone, KA Worringer, S Kommineni, Y Zang, D Cacchiarel, A Meissner, R Adolfsson, S Haggarty, J Madison, M Muller, P Arlotta, Z Fu, G Feng, K Eggan
    Cell Rep, 2018;23(8):2509-2523.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  9. REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways
    Authors: J Drouin-Oue, S Lau, PL Brattås, D Rylander O, K Pircs, DA Grassi, LM Collins, R Vuono, A Andersson, G Westergren, C Graff, L Minthon, H Toresson, RA Barker, J Jakobsson, M Parmar
    EMBO Mol Med, 2017;9(8):1117-1131.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells
    Authors: M Höllerhage, C Moebius, J Melms, WH Chiu, JN Goebel, T Chakroun, T Koeglsperg, WH Oertel, TW Rösler, M Bickle, GU Höglinger
    Sci Rep, 2017;7(1):11469.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming
    Authors: T Ruetz, U Pfisterer, B Di Stefano, J Ashmore, M Beniazza, TV Tian, DF Kaemena, L Tosti, W Tan, JR Manning, E Chantzoura, DR Ottosson, S Collombet, A Johnsson, E Cohen, K Yusa, S Linnarsson, T Graf, M Parmar, K Kaji
    Cell Stem Cell, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Altered Differentiation Potential of Gaucher's Disease iPSC Neuronal Progenitors due to Wnt/?-Catenin Downregulation
    Authors: O Awad, LM Panicker, RM Deranieh, MP Srikanth, RA Brown, A Voit, T Peesay, TS Park, ET Zambidis, RA Feldman
    Stem Cell Reports, 2017;9(6):1853-1867.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Acellular Mouse Kidney ECM can be Used as a Three-Dimensional Substrate to Test the Differentiation Potential of Embryonic Stem Cell Derived Renal Progenitors
    Authors: M Sambi, T Chow, J Whiteley, M Li, S Chua, V Raileanu, IM Rogers
    Stem Cell Rev, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  14. The protein phosphatase 1 regulator NIPP1 is essential for mammalian spermatogenesis
    Authors: M Ferreira, S Boens, C Winkler, K Szekér, I Verbinnen, A Van Eynde, M Fardilha, M Bollen
    Sci Rep, 2017;7(1):13364.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Isolation and characterization of string-forming female germline stem cells from ovaries of neonatal mice
    Authors: J Liu, D Shang, Y Xiao, P Zhong, H Cheng, R Zhou
    J. Biol. Chem., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus
    Authors: N Avaliani, U Pfisterer, A Heuer, M Parmar, M Kokaia, M Andersson
    Stem Cells Int, 2017;2017(0):5718608.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress
    Authors: S Menges, G Minakaki, PM Schaefer, H Meixner, I Prots, U Schlötzer-, K Friedland, B Winner, TF Outeiro, KF Winklhofer, CA von Arnim, W Xiang, J Winkler, J Klucken
    Sci Rep, 2017;7(0):42942.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Rapid differentiation of human pluripotent stem cells into functional neurons by mRNAs encoding transcription factors
    Authors: SK Goparaju, K Kohda, K Ibata, A Soma, Y Nakatake, T Akiyama, S Wakabayash, M Matsushita, M Sakota, H Kimura, M Yuzaki, SB Ko, MS Ko
    Sci Rep, 2017;7(0):42367.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Higher-Order Kidney Organogenesis from Pluripotent Stem Cells
    Authors: A Taguchi, R Nishinakam
    Cell Stem Cell, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Neurotoxic reactive astrocytes are induced by activated microglia
    Authors: SA Liddelow, KA Guttenplan, LE Clarke, FC Bennett, CJ Bohlen, L Schirmer, ML Bennett, AE Mnch, WS Chung, TC Peterson, DK Wilton, A Frouin, BA Napier, N Panicker, M Kumar, MS Buckwalter, DH Rowitch, VL Dawson, TM Dawson, B Stevens, BA Barres
    Nature, 2017;541(7638):481-487.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents
    Authors: JC Niclis, CW Gantner, WF Alsanie, SJ McDougall, CR Bye, AG Elefanty, EG Stanley, JM Haynes, CW Pouton, LH Thompson, CL Parish
    Stem Cells Transl Med, 2017;6(3):937-948.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Alternative NHEJ pathway proteins as components of MYCN oncogenic activity in human neural crest stem cell differentiation: implications for neuroblastoma initiation
    Authors: EA Newman, S Chukkapall, D Bashllari, TT Thomas, RA Van Noord, ER Lawlor, MJ Hoenerhoff, AW Opipari, VP Opipari
    Cell Death Dis, 2017;8(12):3208.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  23. RET-mediated glial cell line derived neurotrophic factor signaling inhibits mouse prostate development
    Authors: HJ Park, EC Bolton
    Development, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  24. Optimal culture conditions are critical for efficient expansion of human testicular somatic and germ cells in�vitro
    Authors: I Gat, L Maghen, M Filice, B Wyse, K Zohni, K Jarvi, KC Lo, A Gauthier F, C Librach
    Fertil. Steril, 2017;107(3):595-605.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. A robust vitronectin-derived peptide for the scalable long-term expansion and neuronal differentiation of human pluripotent stem cell (hPSC)-derived neural progenitor cells (hNPCs)
    Authors: Divya Varun
    Acta Biomater, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Small molecules increase direct neural conversion of human fibroblasts
    Sci Rep, 2016;6(0):38290.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Histones facilitate ?-synuclein aggregation during neuronal apoptosis
    Authors: Peizhou Jiang
    Acta Neuropathol, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Sustained synchronized neuronal network activity in a human astrocyte co-culture system
    Sci Rep, 2016;6(0):36529.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles
    Authors: Raquel Pinho
    PLoS ONE, 2016;11(6):e0157852.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells
    Sci Rep, 2016;6(0):32532.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Microfabric Vessels for Embryoid Body Formation and Rapid Differentiation of Pluripotent Stem Cells
    Sci Rep, 2016;6(0):31063.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Effects of Feeder Cells on Dopaminergic Differentiation of Human Embryonic Stem Cells
    Authors: Z Zhao, Y Ma, Z Chen, Q Liu, Q Li, D Kong, K Yuan, L Hu, T Wang, X Chen, Y Peng, W Jiang, Y Yu, X Liu
    Front Cell Neurosci, 2016;10(0):291.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Analysis of induced pluripotent stem cells carrying 22q11.2 deletion
    Authors: T Yoshikawa
    Transl Psychiatry, 2016;6(11):e934.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients
    Elife, 2016;5(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Isolation, expansion and neural differentiation of stem cells from human plucked hair: a further step towards autologous nerve recovery
    Authors: Margriet A Huisman
    Cytotechnology, 2016;68(5):1849-58.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Increased susceptibility to a? toxicity in neuronal cultures derived from familial Azheimer's disease (PSEN1-A246E) induced pluripotent stem cells
    Authors: Enrique Armijo
    Neurosci. Lett, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
    Authors: Chen X, Wales P, Quinti L, Zuo F, Moniot S, Herisson F, Rauf N, Wang H, Silverman R, Ayata C, Maxwell M, Steegborn C, Schwarzschild M, Outeiro T, Kazantsev A
    PLoS ONE, 2015;10(1):e0116919.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Microglial AGE-albumin is critical for neuronal death in Parkinson's disease: a possible implication for theranostics
    Int J Nanomedicine, 2015;10(0):281-92.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells.
    Authors: Merkle F, Maroof A, Wataya T, Sasai Y, Studer L, Eggan K, Schier A
    Development, 2015;142(4):633-43.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.
    Authors: Laguna A, Schintu N, Nobre A, Alvarsson A, Volakakis N, Jacobsen J, Gomez-Galan M, Sopova E, Joodmardi E, Yoshitake T, Deng Q, Kehr J, Ericson J, Svenningsson P, Shupliakov O, Perlmann T
    Nat Neurosci, 2015;18(6):826-35.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability.
    Authors: Devlin, Anna-Cla, Burr, Karen, Borooah, Shyamang, Foster, Joshua D, Cleary, Elaine M, Geti, Imbisaat, Vallier, Ludovic, Shaw, Christop, Chandran, Siddhart, Miles, Gareth B
    Nat Commun, 2015;6(0):5999.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Assessment of TTX-s and TTX-r Action Potential Conduction along Neurites of NGF and GDNF Cultured Porcine DRG Somata.
    Authors: Jonas R, Klusch A, Schmelz M, Petersen M, Carr R
    PLoS ONE, 2015;10(9):e0139107.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Noggin Over-Expressing Mouse Embryonic Fibroblasts and MS5 Stromal Cells Enhance Directed Differentiation of Dopaminergic Neurons from Human Embryonic Stem Cells.
    Authors: Lim M, Shin M, Lee S, Minn Y, Hoh J, Cho Y, Kim D, Lee S, Kim C, Park C
    PLoS ONE, 2015;10(9):e0138460.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain.
    Authors: Pereira, Maria, Pfisterer, Ulrich, Rylander, Daniella, Torper, Olof, Lau, Shong, Lundblad, Martin, Grealish, Shane, Parmar, Malin
    Sci Rep, 2014;4(0):6330.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Histone hyperacetylation up-regulates protein kinase Cdelta in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease.
    Authors: Jin H, Kanthasamy A, Harischandra D, Kondru N, Ghosh A, Panicker N, Anantharam V, Rana A, Kanthasamy A
    J Biol Chem, 2014;289(50):34743-67.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Lineage-specific regulation of epigenetic modifier genes in human liver and brain.
    Authors: Weng, Matthias, Natarajan, Karthick, Scholz, Diana, Ivanova, Violeta, Sachinidis, Agapios, Hengstler, Jan G, Waldmann, Tanja, Leist, Marcel
    PLoS ONE, 2014;9(7):e102035.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  47. iPSC-derived forebrain neurons from FXS individuals show defects in initial neurite outgrowth.
    Authors: Doers, Matthew, Musser, Michael, Nichol, Robert, Berndt, Erich R, Baker, Mei, Gomez, Timothy, Zhang, Su-Chun, Abbeduto, Leonard, Bhattacharyya, Anita
    Stem Cells Dev, 2014;23(15):1777-87.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Characterization of the stability and bio-functionality of tethered proteins on bioengineered scaffolds: implications for stem cell biology and tissue repair.
    Authors: Wang T, Bruggeman K, Sheean R, Turner B, Nisbet D, Parish C
    J Biol Chem, 2014;289(21):15044-51.
    Species: Synthetic
    Sample Types: Complex Sample Type
    Applications: Bioassay
  49. Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins.
    Authors: Peng, Lisheng, Adler, Michael, Demogines, Ann, Borrell, Andrew, Liu, Huisheng, Tao, Liang, Tepp, William, Zhang, Su-Chun, Johnson, Eric A, Sawyer, Sara L, Dong, Min
    PLoS Pathog, 2014;10(7):e1004177.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Direct conversion of human fibroblasts into neuronal restricted progenitors.
    Authors: Zou, Qingjian, Yan, Quanmei, Zhong, Juan, Wang, Kepin, Sun, Haitao, Yi, Xiaoling, Lai, Liangxue
    J Biol Chem, 2014;289(8):5250-60.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.
    Authors: Yang Y, Gupta S, Kim K, Powers B, Cerqueira A, Wainger B, Ngo H, Rosowski K, Schein P, Ackeifi C, Arvanites A, Davidow L, Woolf C, Rubin L
    Cell Stem Cell, 2013;12(6):713-26.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Functional neuroprotection and efficient regulation of GDNF using destabilizing domains in a rodent model of Parkinson's disease.
    Authors: Quintino L, Manfre G, Wettergren E, Namislo A, Isaksson C, Lundberg C
    Mol Ther, 2013;21(12):2169-80.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. MicroRNA-based promotion of human neuronal differentiation and subtype specification.
    Authors: Stappert L, Borghese L, Roese-Koerner B, Weinhold S, Koch P, Terstegge S, Uhrberg M, Wernet P, Brustle O
    PLoS ONE, 2013;8(3):e59011.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. A human Dravet syndrome model from patient induced pluripotent stem cells.
    Authors: Higurashi N, Uchida T, Lossin C, Misumi Y, Okada Y, Akamatsu W, Imaizumi Y, Zhang B, Nabeshima K, Mori M, Katsurabayashi S, Shirasaka Y, Okano H, Hirose S
    Mol Brain, 2013;6(0):19.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. alpha-Synuclein oligomers impair neuronal microtubule-kinesin interplay.
    Authors: Prots I, Veber V, Brey S, Campioni S, Buder K, Riek R, Bohm K, Winner B
    J Biol Chem, 2013;288(30):21742-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. MEK/ERK signaling directly and indirectly contributes to the cyclical self-renewal of spermatogonial stem cells.
    Authors: Hasegawa K, Namekawa S, Saga Y
    Stem Cells, 2013;31(11):2517-27.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture Substrate
  57. RET is a potential tumor suppressor gene in colorectal cancer.
    Authors: Luo, Y, Tsuchiya, K D, Il Park, D, Fausel, R, Kanngurn, S, Welcsh, P, Dzieciatkowski, S, Wang, J, Grady, W M
    Oncogene, 2013;32(16):2037-47.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Isolation, characterization and propagation of mitotically active germ cells from adult mouse and human ovaries.
    Authors: Woods D, Tilly J
    Nat Protoc, 2013;8(5):966-88.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. RET PLC-gamma phosphotyrosine binding domain regulates Ca2+ signaling and neocortical neuronal migration.
    Authors: Lundgren TK, Nakahata K, Fritz N, Rebellato P, Zhang S, Uhlen P
    PLoS ONE, 2012;7(2):e31258.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth.
    Authors: Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV
    J. Biol. Chem., 2011;286(34):30034-46.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Surface Plasmon Resonance
  61. Glial cell line-derived neurotrophic factor and endothelial cells promote self-renewal of rabbit germ cells with spermatogonial stem cell properties.
    Authors: Kubota H, Wu X, Goodyear SM, Avarbock MR, Brinster RL
    FASEB J., 2011;25(0):2604-14.
    Species: Rabbit
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Pharmacokinetics and bioactivity of glial cell line-derived factor (GDNF) and neurturin (NTN) infused into the rat brain.
    Authors: Hadaczek P, Johnston L, Forsayeth J, Bankiewicz KS
    Neuropharmacology, 2010;58(7):1114-21.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  63. Sustained intraspinal delivery of neurotrophic factor encapsulated in biodegradable nanoparticles following contusive spinal cord injury.
    Authors: Wang YC, Wu YT, Huang HY, Lin HI, Lo LW, Tzeng SF, Yang CS
    Biomaterials, 2008;29(34):4546-53.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  64. A novel immunoprecipitation strategy identifies a unique functional mimic of the glial cell line-derived neurotrophic factor family ligands in the pathogen Trypanosoma cruzi.
    Authors: Lu B, PereiraPerrin M
    Infect. Immun., 2008;76(8):3530-8.
    Species: Bacteria
    Sample Types: Trypanosoma
    Applications: ELISA capture
  65. Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons.
    Authors: Ladewig J, Koch P, Endl E, Meiners B, Opitz T, Couillard-Despres S, Aigner L, Brustle O
    Stem Cells, 2008;26(7):1705-12.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage.
    Authors: Pankratz MT, Li XJ, Lavaute TM, Lyons EA, Chen X, Zhang SC
    Stem Cells, 2007;25(6):1511-20.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  67. SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation.
    Authors: Ai X, Kitazawa T, Do AT, Kusche-Gullberg M, Labosky PA, Emerson CP
    Development, 2007;134(18):3327-38.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  68. Endothelin-3 regulates neural crest cell proliferation and differentiation in the hindgut enteric nervous system.
    Authors: Nagy N, Goldstein AM
    Dev. Biol., 2006;293(1):203-17.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: Bioassay
  69. Trophic factor modulation of cocaine- and amphetamine-regulated transcript peptide expression in explant cultured guinea-pig cardiac neurons.
    Authors: Girard BM, Young BA, Buttolph TR, Locknar SA, White SL, Parsons RL
    Neuroscience, 2006;139(4):1329-41.
    Species: Guinea Pig
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Multipotent adult progenitor cells from swine bone marrow.
    Authors: Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C
    Stem Cells, 2006;24(11):2355-66.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion.
    Authors: Castelo-Branco G, Sousa KM, Bryja V, Pinto L, Wagner J, Arenas E
    Mol. Cell. Neurosci., 2005;31(2):251-62.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Derivation of midbrain dopamine neurons from human embryonic stem cells.
    Authors: Perrier AL, Tabar V, Barberi T, Rubio ME, Bruses J, Topf N, Harrison NL, Studer L
    Proc. Natl. Acad. Sci. U.S.A., 2004;101(34):12543-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Rapid axoglial signaling mediated by neuregulin and neurotrophic factors.
    Authors: Esper RM, Loeb JA
    J. Neurosci., 2004;24(27):6218-27.
    Species: Chicken
    Sample Types: Whole Cells
    Applications: Bioassay

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Recombinant Human GDNF Protein
By Anonymous on 07/19/2017
Application: Immunoassay Standard

Used for control recovery in the Duo-set GDNF elisa and found that recovery was withing limit


Recombinant Human GDNF Protein
By Anonymous on 05/26/2017
Application: Stem/Immune cell maintenance or differentiation

Recombinant Human GDNF Protein
By Anonymous on 08/01/2016
Application: Stem/Immune cell maintenance or differentiation