Recombinant Human IFN-beta 1a (Mammalian) Protein

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R&D Systems Recombinant Proteins and Enzymes
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Citations (7)

Recombinant Human IFN-beta 1a (Mammalian) Protein Summary

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Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
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Background: IFN-beta

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

Long Name
Interferon beta
Entrez Gene IDs
3456 (Human); 15977 (Mouse); 24481 (Rat)
Alternate Names
Fibroblast interferon; IFB; IFBIFNB; IFF; IFNB; IFNB1; IFNbeta; IFN-beta; interferon beta; interferon, beta 1, fibroblast; MGC96956

Citations for Recombinant Human IFN-beta 1a (Mammalian) Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

7 Citations: Showing 1 - 7
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  1. Decreased expression of miR-29 family associated with autoimmune myasthenia gravis
    Authors: MA Cron, CA Payet, OM Fayet, S Maillard, F Truffault, E Fadel, J Guihaire, S Berrih-Akn, A Liston, R Le Panse
    J Neuroinflammation, 2020;17(1):294.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-beta Therapy.
    Authors: Rasouli J, Ciric B, Imitola J, Gonnella P, Hwang D, Mahajan K, Mari E, Safavi F, Leist T, Zhang G, Rostami A
    J Immunol, 2015;194(11):5085-93.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. A 20-amino-acid deletion in the neuraminidase stalk and a five-amino-acid deletion in the NS1 protein both contribute to the pathogenicity of H5N1 avian influenza viruses in mallard ducks.
    Authors: Li, Yanfang, Chen, Sujuan, Zhang, Xiaojian, Fu, Qiang, Zhang, Zhiye, Shi, Shaohua, Zhu, Yinbiao, Gu, Min, Peng, Daxin, Liu, Xiufan
    PLoS ONE, 2014;9(4):e95539.
    Species: Primate
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Dual regulation of osteopontin production by TLR stimulation in dendritic cells.
    Authors: Salvi V, Scutera S, Rossi S, Zucca M, Alessandria M, Greco D, Bosisio D, Sozzani S, Musso T
    J Leukoc Biol, 2013;94(1):147-58.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Enterovirus 71 protease 2Apro targets MAVS to inhibit anti-viral type I interferon responses.
    Authors: Wang, Bei, Xi, Xueyan, Lei, Xiaobo, Zhang, Xiaoyan, Cui, Sheng, Wang, Jianwei, Jin, Qi, Zhao, Zhendong
    PLoS Pathog, 2013;9(3):e1003231.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  6. Dobrava-Belgrade hantavirus from Germany shows receptor usage and innate immunity induction consistent with the pathogenicity of the virus in humans.
    Authors: Popugaeva E, Witkowski PT, Schlegel M, Ulrich RG, Auste B, Rang A, Kruger DH, Klempa B
    PLoS ONE, 2012;7(4):e35587.
    Species: Human
    Sample Types: Whole Cells
    Applications: Control
  7. Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines.
    Authors: Witte K, Gruetz G, Volk HD, Looman AC, Asadullah K, Sterry W, Sabat R, Wolk K
    Genes Immun., 2009;10(8):702-14.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay


  1. Why is recombinant Human Interferon-beta 1a (Catalog #'s 11415-1 and 11410-2) formulated with acetic acid?

    • Acetic acid was added to prevent aggregation.

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