Recombinant Human IL-13 Protein

Formulations:
Catalog # Availability Size / Price Qty
213-ILB-005
213-ILB-025
213-ILB-100
Graph showing dose-dependent bioactivity of Human IL-13 protein
1 Image
Product Details
Citations (78)
FAQs
Reviews (6)

Recombinant Human IL-13 Protein Summary

Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED50 for this effect is 0.5-2.5 ng/mL.
Source
E. coli-derived human IL-13 protein
Gly21-Asn132
Accession #
N-terminal Sequence
Analysis
Gly21
Predicted Molecular Mass
12.3 kDa
SDS-PAGE
9 kDa, reducing conditions

Product Datasheets

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

213-ILB

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

213-ILB/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 100 μg/mL in PBS.
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Data Image

Bioactivity Bioactivity of Human IL-13 Protein View Larger

Recombinant human IL-13 (213-ILB) stimulates proliferation in the TF-1 human erythroleukemic cell line. The ED50 for this effect is 0.5-2.5 ng/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IL-13

Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells (1‑3). Mature human IL-13 shares approximately 58% amino acid sequence identity with mouse and rat IL-13. Despite the low homology, it exhibits cross‑species activity between human, mouse, and rat (4). IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances by macrophages, fibroblasts, and endothelial cells. On B cells, it promotes cellular activation, immunoglobulin class switching to IgE, and the up‑regulation of CD23/Fc epsilon RII (1, 5). IL-13 binds with low affinity to the transmembrane IL-13 R alpha 1 which then forms a signaling complex with the transmembrane IL-4 R alpha (6‑8). This high affinity receptor complex also functions as the type 2 IL-4 receptor (6, 7). IL‑13 R alpha 2 inhibits responses to both IL-13 and IL-4. It binds IL-13 with high affinity (9, 10) and prevents IL-13 from signaling through the IL-13 R alpha 1/IL-4 R alpha complex (11, 12). It also blocks signaling through IL-4-occupied IL-13 R alpha 1/IL-4 R alpha receptor complexes (12, 13). In addition, IL-13-bound IL-13 R alpha 2 can directly promote tumor cell invasiveness and the development of tissue fibrosis (14‑16).

References
  1. Saggini, A. et al. (2011) Int. J. Immunopathol. Pharmacol. 24:305.
  2. Gallo, E. et al. (2012) Eur. J. Immunol. 42:2322.
  3. Liang, H.E. et al. (2012) Nat. Immunol. 13:58.
  4. Ruetten, H. and C. Thiemermann (1997) Shock 8:409.
  5. McKenzie, A.N. et al. (1993) Proc. Natl. Acad. Sci. USA 90:3735.
  6. Aman, M.J. et al. (1996) J. Biol. Chem. 271:29265.
  7. Zurawski, S.M. et al. (1995) J. Biol. Chem. 270:13869.
  8. Andrews, A.L. et al. (2002) J. Biol. Chem. 277:46073.
  9. Chen, W. et al. (2009) J. Immunol. 183:7870.
  10. Daines, M.O. et al. (2007) J. Allergy Clin. Immunol. 119:375.
  11. Kasaian, M.T. et al. (2011) J. Immunol. 187:561.
  12. Andrews, A.-L. et al. (2006) J. Allergy Clin. Immunol. 118:858.
  13. Rahaman, S.O. et al. (2002) Cancer Res. 62:1103.
  14. Fujisawa, T. et al. (2009) Cancer Res. 69:8678.
  15. Fujisawa, T. et al. (2011) Int. J. Cancer 131:344.
  16. Fichtner-Feigl, S. et al. (2006) Nat. Med. 12:99.
Long Name
Interleukin 13
Entrez Gene IDs
3596 (Human); 16163 (Mouse); 116553 (Rat); 574325 (Primate)
Alternate Names
ALRHMGC116789; BHR1interleukin-13; IL13; IL-13; IL-13MGC116788; interleukin 13; MGC116786; NC30; P600

Citations for Recombinant Human IL-13 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

78 Citations: Showing 1 - 10
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  1. Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins
    Authors: RA Lu, AA Zeki, S Ram-Mohan, N Nguyen, Y Bai, K Chmiel, S Pecic, X Ai, R Krishnan, CC Ghosh
    Front Pharmacol, 2020;11(0):469.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  2. HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment
    Authors: YD Kim, SM Park, HC Ha, AR Lee, H Won, H Cha, S Cho, JM Cho
    J Cancer, 2020;11(14):4059-4072.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Cycling hypoxia promotes a pro-inflammatory phenotype in macrophages via JNK/p65 signaling pathway
    Authors: V Delprat, C Tellier, C Demazy, M Raes, O Feron, C Michiels
    Sci Rep, 2020;10(1):882.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. M2 Macrophages Promote HCC Cells Invasion and Migration via miR-149-5p/MMP9 Signaling
    Authors: G Liu, L Yin, X Ouyang, K Zeng, Y Xiao, Y Li
    J Cancer, 2020;11(5):1277-1287.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  5. Linking the effects of helminth infection, diet and the gut microbiota with human whole-blood signatures
    Authors: SC Lee, MS Tang, AV Easton, JC Devlin, LL Chua, I Cho, FM Moy, TF Khang, YAL Lim, P Loke
    PLoS Pathog., 2019;15(12):e1008066.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  6. The role of IL-36? and its regulation in eosinophilic inflammation in allergic rhinitis
    Authors: X Qin, M Liu, S Zhang, C Wang, T Zhang
    Cytokine, 2019;117(0):84-90.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. IL-4 and IL-17A Cooperatively Promote Hydrogen Peroxide Production, Oxidative DNA Damage, and Upregulation of Dual Oxidase 2 in Human Colon and Pancreatic Cancer Cells
    Authors: Y Wu, MM Konaté, J Lu, H Makhlouf, R Chuaqui, S Antony, JL Meitzler, MJ Difilippan, H Liu, A Juhasz, G Jiang, I Dahan, K Roy, JH Doroshow
    J. Immunol., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. TNF-α and IL-17A induce the expression of lympho-epithelial Kazal-type inhibitor in epidermal keratinocytes
    Authors: S Sugihara, S Sugimoto, K Tachibana, M Kobashi, H Nomura, T Miyake, Y Hirai, O Yamasaki, S Morizane
    J. Dermatol. Sci., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  9. Alpha-linolenic acid enhances the phagocytic and secretory functions of alternatively activated macrophages in part via changes to the oxylipin profile
    Authors: SD Pauls, LA Rodway, T Winter, CG Taylor, P Zahradka, HM Aukema
    Int. J. Biochem. Cell Biol., 2019;119(0):105662.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling
    Authors: X Unamuno, J Gómez-Ambr, B Ramírez, A Rodríguez, S Becerril, V Valentí, R Moncada, C Silva, J Salvador, G Frühbeck, V Catalán
    Cell. Mol. Immunol., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
    Authors: N Berges, MS Nawaz, T Børresdatt, L Hagen, M Bjørås, JK Laerdahl, I Alseth
    PLoS ONE, 2019;14(11):e0225081.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  12. MicroRNA-31 and MicroRNA-155 Are Overexpressed in Ulcerative Colitis and Regulate IL-13 Signaling by Targeting Interleukin 13 Receptor ?-1
    Authors: M Gwiggner, RT Martinez-N, SR Whiteoak, VP Bondanese, A Claridge, JE Collins, JRF Cummings, T Sanchez-El
    Genes (Basel), 2018;9(2):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Lipid abnormalities in atopic skin are driven by type 2 cytokines
    Authors: E Berdyshev, E Goleva, I Bronova, N Dyjack, C Rios, J Jung, P Taylor, M Jeong, CF Hall, BN Richers, KA Norquest, T Zheng, MA Seibold, DY Leung
    JCI Insight, 2018;3(4):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Proton irradiation orchestrates macrophage reprogramming through NF?B signaling
    Authors: G Genard, AC Wera, C Huart, B Le Calve, S Penninckx, A Fattacciol, T Tabarrant, C Demazy, N Ninane, AC Heuskin, S Lucas, C Michiels
    Cell Death Dis, 2018;9(7):728.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. BET inhibition in advanced cutaneous T cell lymphoma is synergistically potentiated by BCL2 inhibition or HDAC inhibition
    Authors: SR Kim, JM Lewis, BM Cyrenne, PF Monico, FN Mirza, KR Carlson, FM Foss, M Girardi
    Oncotarget, 2018;9(49):29193-29207.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Tumor-associated macrophages derived CCL18 promotes metastasis in squamous cell carcinoma of the head and neck
    Authors: L She, Y Qin, J Wang, C Liu, G Zhu, G Li, M Wei, C Chen, G Liu, D Zhang, X Chen, Y Wang, Y Qiu, Y Tian, X Zhang, Y Liu, D Huang
    Cancer Cell Int., 2018;18(0):120.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. IL-13 induces periostin and eotaxin expression in human primary alveolar epithelial cells: Comparison with paired airway epithelial cells
    Authors: Y Ito, R Al Mubarak, N Roberts, K Correll, W Janssen, J Finigan, R Mishra, HW Chu
    PLoS ONE, 2018;13(4):e0196256.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Sodium channel TRPM4 and sodium/calcium exchangers (NCX) cooperate in the control of Ca2+-induced mucin secretion from goblet cells
    Authors: G Cantero-Re, CM Butnaru, N Brouwers, S Mitrovic, MA Valverde, V Malhotra
    J. Biol. Chem., 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Carcinoembryonic antigen as a marker of radioresistance in colorectal cancer: a potential role of macrophages
    Authors: EY Huang, JC Chang, HH Chen, CY Hsu, HC Hsu, KL Wu
    BMC Cancer, 2018;18(1):321.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Effect of colorectal cancer-derived extracellular vesicles on the immunophenotype and cytokine secretion profile of monocytes and macrophages
    Authors: I Pop?na, A ?bols, L Saul?te, K Pleiko, E Zandberga, K J?kabsons, E Endzeli?š, A Llorente, A Lin?, U Rieksti?a
    Cell Commun. Signal, 2018;16(1):17.
    Species: Human
    Sample Types: Whole Cells
    Applications: Differentiation
  21. TNFSF14 (LIGHT) Exhibits Inflammatory Activities in Lung Fibroblasts Complementary to IL-13 and TGF-β
    Authors: R da Silva A, AK Mehta, L Madge, J Tocker, M Croft
    Front Immunol, 2018;9(0):576.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  22. GATA3 regulates FLG and FLG2 expression in human primary keratinocytes
    Authors: J Zeitvogel, N Jokmin, S Rieker, I Klug, C Brandenber, T Werfel
    Sci Rep, 2017;7(1):11847.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Development of Combining of Human Bronchial Mucosa Models with XposeALI? for Exposure of Air Pollution Nanoparticles
    Authors: J Ji, A Hedelin, M Malml”f, V Kessler, G Seisenbaev, P Gerde, L Palmberg
    PLoS ONE, 2017;12(1):e0170428.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis
    Authors: R Bruen, S Curley, S Kajani, D Crean, ME O'Reilly, MB Lucitt, CG Godson, FC McGillicud, O Belton
    Cardiovasc Diabetol, 2017;16(1):143.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Pulmonary microRNA profiles identify involvement of Creb1 and Sec14l3 in bronchial epithelial changes in allergic asthma
    Authors: S Bartel, N Schulz, F Alessandri, AC Schamberge, P Pagel, FJ Theis, K Milger, E Noessner, SM Stick, A Kicic, O Eickelberg, RJ Freishtat, S Krauss-Ets
    Sci Rep, 2017;7(0):46026.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Interferon-? induced insufficient autophagy contributes to p62-dependent apoptosis of epithelial cells in chronic rhinosinusitis with nasal polyps
    Authors: BF Wang, PP Cao, ZC Wang, ZY Li, ZZ Wang, J Ma, B Liao, YK Deng, XB Long, K Xu, H Wang, H Wang, M Zeng, X Lu, Z Liu
    Allergy, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression
    Authors: Y Wang, JB Mumm, R Herbst, R Kolbeck, Y Wang
    J. Immunol., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Therapeutic Effect of Novel Single-Stranded RNAi Agent Targeting Periostin in Eyes with Retinal Neovascularization
    Authors: T Nakama, S Yoshida, K Ishikawa, Y Kubo, Y Kobayashi, Y Zhou, S Nakao, T Hisatomi, Y Ikeda, K Takao, K Yoshikawa, A Matsuda, J Ono, S Ohta, K Izuhara, A Kudo, KH Sonoda, T Ishibashi
    Mol Ther Nucleic Acids, 2017;6(0):279-289.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Thymic stromal chemokine TSLP acts through Th2 cytokine production to induce cutaneous T cell lymphoma
    Cancer Res, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Structural Characterisation Reveals Mechanism of IL-13 Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13R?1 and IL-13R?2
    Authors: B Popovic
    J. Mol. Biol, 2016;0(0):.
    Applications: Bioassay
  31. Classical and alternative macrophages have impaired function during acute and chronic HIV-1 infection
    Authors: Leonardo J Galvão-Lim
    Braz J Infect Dis, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Increased Interleukin-32 Levels in Obesity Promote Adipose Tissue Inflammation and Extracellular Matrix Remodeling: Effect of Weight Loss
    Authors: Victoria Catalán
    Diabetes, 2016;65(12):3636-3648.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. JAK-STAT6 Pathway Inhibitors Block Eotaxin-3 Secretion by Epithelial Cells and Fibroblasts from Esophageal Eosinophilia Patients: Promising Agents to Improve Inflammation and Prevent Fibrosis in EoE
    Authors: Edaire Cheng
    PLoS ONE, 2016;11(6):e0157376.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Anti-inflammatory and immunomodulatory effects of Aquaphilus dolomiae extract on in vitro models
    Authors: Nathalie Castex-Riz
    Clin Cosmet Investig Dermatol, 2016;9(0):421-434.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics
    Authors: S O'Reilly, M Ciechomska, N Fullard, S Przyborski, JM van Laar
    Sci Rep, 2016;6(0):25066.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Expression of surfactant protein D in airways of asthmatics and interleukin-13 modulation of surfactant protein D in human models of airway epithelium.
    Authors: Xu J, Singhera G, Dorscheid D
    Respir Res, 2015;16(0):26.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  37. Long-Acting Beta Agonists Enhance Allergic Airway Disease.
    Authors: Knight J, Mak G, Shaw J, Porter P, McDermott C, Roberts L, You R, Yuan X, Millien V, Qian Y, Song L, Frazier V, Kim C, Kim J, Bond R, Milner J, Zhang Y, Mandal P, Luong A, Kheradmand F, McMurray J, Corry D
    PLoS ONE, 2015;10(11):e0142212.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Vinpocetine inhibits Streptococcus pneumoniae-induced upregulation of mucin MUC5AC expression via induction of MKP-1 phosphatase in the pathogenesis of otitis media.
    Authors: Lee J, Komatsu K, Lee B, Miyata M, O'Neill Bohn A, Xu H, Yan C, Li J
    J Immunol, 2015;194(12):5990-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. SOCS3 silencing attenuates eosinophil functions in asthma patients.
    Authors: Zafra M, Canas J, Mazzeo C, Gamez C, Sanz V, Fernandez-Nieto M, Quirce S, Barranco P, Ruiz-Hornillos J, Sastre J, del Pozo V
    Int J Mol Sci, 2015;16(3):5434-51.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. An Allergic Lung Microenvironment Suppresses Carbon Nanotube-Induced Inflammasome Activation via STAT6-Dependent Inhibition of Caspase-1.
    Authors: Shipkowski K, Taylor A, Thompson E, Glista-Baker E, Sayers B, Messenger Z, Bauer R, Jaspers I, Bonner J
    PLoS ONE, 2015;10(6):e0128888.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M.
    Authors: Kwofie K, Scott M, Rodrigues R, Guerette J, Radford K, Nair P, Richards C
    Respir Res, 2015;16(0):14.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages.
    Authors: Herova M, Schmid M, Gemperle C, Hersberger M
    J Immunol, 2015;194(5):2330-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. IL-25 induces airways angiogenesis and expression of multiple angiogenic factors in a murine asthma model.
    Authors: Yao, Xiujuan, Wang, Wei, Li, Yan, Huang, Ping, Zhang, Qian, Wang, Jingjing, Wang, Wen, Lv, Zhe, An, Yunqing, Qin, Jianguo, Corrigan, Chris J, Huang, Kewu, Sun, Yongchan, Ying, Sun
    Respir Res, 2015;16(0):39.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Absence of a role for interleukin-13 in inflammatory bowel disease.
    Authors: Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, Hoque S, Ghanbari A, Joe-Njoku I, Giuffrida P, Rovedatti L, Geginat J, Corazza G, MacDonald T
    Eur J Immunol, 2014;44(2):370-85.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. IL-33 stimulates CXCL8/IL-8 secretion in goblet cells but not normally differentiated airway cells.
    Authors: Tanabe T, Shimokawaji T, Kanoh S, Rubin B
    Clin Exp Allergy, 2014;44(4):540-52.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Proton pump inhibitors decrease eotaxin-3 expression in the proximal esophagus of children with esophageal eosinophilia.
    Authors: Park, Jason Y, Zhang, Xi, Nguyen, Nathalie, Souza, Rhonda F, Spechler, Stuart J, Cheng, Edaire
    PLoS ONE, 2014;9(7):e101391.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  47. A thymic stromal lymphopoietin-responsive dendritic cell subset mediates allergic responses in the upper airway mucosa.
    Authors: Melum G, Farkas L, Scheel C, Van Dieren B, Gran E, Liu Y, Johansen F, Jahnsen F, Baekkevold E
    J Allergy Clin Immunol, 2014;134(3):613-621.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy.
    Authors: Ahmad T, Mukherjee S, Pattnaik B, Kumar M, Singh S, Kumar M, Rehman R, Tiwari B, Jha K, Barhanpurkar A, Wani M, Roy S, Mabalirajan U, Ghosh B, Agrawal A
    EMBO J, 2014;33(9):994-1010.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  49. An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma.
    Authors: Voraphani N, Gladwin M, Contreras A, Kaminski N, Tedrow J, Milosevic J, Bleecker E, Meyers D, Ray A, Ray P, Erzurum S, Busse W, Zhao J, Trudeau J, Wenzel S
    Mucosal Immunol, 2014;7(5):1175-85.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Conditioned media from macrophages of M1, but not M2 phenotype, inhibit the proliferation of the colon cancer cell lines HT-29 and CACO-2.
    Authors: Engstrom A, Erlandsson A, Delbro D, Wijkander J
    Int J Oncol, 2014;44(2):385-92.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Origin of myofibroblasts in the fibrotic liver in mice.
    Authors: Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris T, Park T, Liu X, Xu J, Wang P, Paik Y, Meng F, Asagiri M, Murray L, Hofmann A, Iida T, Glass C, Brenner D, Kisseleva T
    Proc Natl Acad Sci U S A, 2014;111(32):E3297-305.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.
    Authors: Pellerin L, Henry J, Hsu C, Balica S, Jean-Decoster C, Mechin M, Hansmann B, Rodriguez E, Weindinger S, Schmitt A, Serre G, Paul C, Simon M
    J Allergy Clin Immunol, 2013;131(4):1094-102.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. 12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma.
    Authors: Mabalirajan U, Rehman R, Ahmad T, Kumar S, Leishangthem G, Singh S, Dinda A, Biswal S, Agrawal A, Ghosh B
    Sci Rep, 2013;3(0):1540.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Pentraxin 3 (PTX3) expression in allergic asthmatic airways: role in airway smooth muscle migration and chemokine production.
    Authors: Zhang J, Shan L, Koussih L, Redhu NS, Halayko AJ, Chakir J, Gounni AS
    PLoS ONE, 2012;7(4):e34965.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. IL-26 Is Overexpressed in Rheumatoid Arthritis and Induces Proinflammatory Cytokine Production and Th17 Cell Generation.
    Authors: Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, Hoppe E, Barre B, Audran M, Bouvard B, Saint-Andre J, Jeannin P
    PLoS Biol, 2012;10(9):e1001395.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Epigenetic modulation enhances the therapeutic effect of anti-IL-13R alpha2 antibody in human mesothelioma xenografts.
    Clin. Cancer Res., 2012;17(9):2819-29.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Regulation of the formyl peptide receptor 1 (FPR1) gene in primary human macrophages.
    Authors: Gemperle C, Schmid M, Herova M, Marti-Jaun J, Wuest S, Loretz C, Hersberger M
    PLoS ONE, 2012;7(11):e50195.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Expression and regulation of CCL15 by human airway smooth muscle cells.
    Authors: Joubert P, Lajoie-Kadoch S, Wellemans V, Létuvé S, Tulic MK, Halayko AJ, Hamid Q
    Clin. Exp. Allergy, 2011;42(1):85-94.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines.
    Authors: Ma P, Bian F, Wang Z, Zheng X, Chotikavanich S, Pflugfelder SC, Li DQ
    Invest. Ophthalmol. Vis. Sci., 2009;50(6):2702-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Inhibition of double-stranded RNA-induced TSLP in human keratinocytes by glucocorticoids.
    Authors: Le TA, Takai T, Kinoshita H, Suto H, Ikeda S, Okumura K, Ogawa H
    Allergy, 2009;64(8):1231-2.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response.
    Authors: Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A
    J. Allergy Clin. Immunol., 2009;123(1):59-66.e4.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps.
    Authors: Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R, Conley D, Grammer LC, Kern R, Schleimer RP
    J. Allergy Clin. Immunol., 2008;121(6):1385-92, 1392.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Divergent effects of hypoxia on dendritic cell functions.
    Authors: Mancino A, Schioppa T, Larghi P, Pasqualini F, Nebuloni M, Chen IH, Sozzani S, Austyn JM, Mantovani A, Sica A
    Blood, 2008;112(9):3723-34.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells.
    Authors: Liu TY, Uemura Y, Suzuki M, Narita Y, Hirata S, Ohyama H, Ishihara O, Matsushita S
    Eur. J. Immunol., 2008;38(4):1012-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Expression and regulation of CCR1 by airway smooth muscle cells in asthma.
    Authors: Joubert P, Lajoie-Kadoch S, Welman M, Dragon S, Letuvee S, Tolloczko B, Halayko AJ, Gounni AS, Maghni K, Hamid Q
    J. Immunol., 2008;180(2):1268-75.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Development of an in vitro potency bioassay for therapeutic IL-13 antagonists: the A-549 cell bioassay.
    Authors: Miller R, Sadhukhan R, Wu C
    J. Immunol. Methods, 2008;334(1):134-41.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  67. TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells.
    Authors: Kato A, Favoreto S, Avila PC, Schleimer RP
    J. Immunol., 2007;179(2):1080-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Cigarette smoke synergistically enhances respiratory mucin induction by proinflammatory stimuli.
    Authors: Baginski TK, Dabbagh K, Satjawatcharaphong C, Swinney DC
    Am. J. Respir. Cell Mol. Biol., 2006;35(2):165-74.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Allergic airway inflammation inhibits pulmonary antibacterial host defense.
    Authors: Beisswenger C, Kandler K, Hess C, Garn H, Felgentreff K, Wegmann M, Renz H, Vogelmeier C, Bals R
    J. Immunol., 2006;177(3):1833-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Th2 cytokine response in Major Depressive Disorder patients before treatment.
    Authors: Pavon L, Kiryushko D, Novitskaya V, Sandoval-Lopez G, Eugenia Hernandez M, Soroka V, Klingelhofer J, Loria F, Estrada I, Lukanidin E, Berezin V, Perez M, Moreno J, Bock E, Avila U, Leff P, Anton B, Heinze G
    J. Neuroimmunol., 2006;172(1):156-65.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  71. Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus.
    Authors: Howell MD, Gallo RL, Boguniewicz M, Jones JF, Wong C, Streib JE, Leung DY
    Immunity, 2006;24(3):341-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Protection of human conjunctival fibroblasts from NO-induced apoptosis by interleukin-4 or interleukin-13.
    Authors: Fujitsu Y, Fukuda K, Kimura K, Seki K, Kumagai N, Nishida T
    Invest. Ophthalmol. Vis. Sci., 2005;46(3):797-802.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells.
    Authors: Kahlon KS, Brown C, Cooper LJ, Raubitschek A, Forman SJ, Jensen MC
    Cancer Res., 2004;64(24):9160-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Differential effect of IL-4 and IL-13 on the expression of recombination-activating genes in mature B cells from human peripheral blood.
    Authors: Kajiwara K, Shinazawa M, Morishima H, Yanagihara Y
    Cell. Immunol., 2004;227(2):121-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways.
    Authors: Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R
    J. Immunol., 2004;173(5):3482-91.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Production of interleukin-13 by human dendritic cells after stimulation with protein allergens is a key factor for induction of T helper 2 cytokines and is associated with activation of signal transducer and activator of transcription-6.
    Authors: Bellinghausen I, Brand P, Bottcher I, Klostermann B, Knop J, Saloga J
    Immunology, 2003;108(2):167-76.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Eosinophils express functional IL-13 in eosinophilic inflammatory diseases.
    Authors: Schmid-Grendelmeier P, Altznauer F, Fischer B, Bizer C, Straumann A, Menz G, Blaser K, Wuthrich B, Simon HU
    J. Immunol., 2002;169(2):1021-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells.
    Authors: Liu X, Kohyama T, Wang H, Zhu YK, Wen FQ, Kim HJ, Romberger DJ, Rennard SI
    Am. J. Physiol. Lung Cell Mol. Physiol., 2002;282(5):L1049-56.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

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Recombinant Human IL-13 Protein
By Anonymous on 08/30/2019
Application: Cell migration/motility

Recombinant Human IL-13 Protein
By Anonymous on 08/16/2019
Application: In vitro bioactivity in cell culture
Reason for Rating: Worked greatly in human PBMC assay

Recombinant Human IL-13 Protein
By Anonymous on 06/09/2019
Application: In vitro bioactivity in cell culture
Reason for Rating: Cells supplied with 20ng/ml IL-4 and 100ng/ml of GM-CSF to differentiate dendritic cells

Recombinant Human IL-13 Protein
By Anonymous on 11/16/2018
Application: CellProlif
Reason for Rating: Cells were supplied with the cytokinetreatments: 50 ng /ml GM-CSF and 10 ng/ ml1 of IL-13 to differentiate DC cells

Recombinant Human IL-13 Protein
By Anonymous on 04/02/2018
Application: In vitro bioactivity in cell culture

Recombinant Human IL-13 Protein
By Anonymous on 01/20/2016
Application: In vitro bioactivity in cell culture
Reason for Rating: IL-13 is a known to phosphorylate STAT-6. In my experiment, fibroblast cells were incubated for 30min and 4hr with IL-13 and then STAT-6 phosphorylation was measured via western blot. IL-13 phosphorylated STAT-6 as expected.