Recombinant Human IL-13 Protein

Analyzed by SEC-MALS

Carrier Free

Catalog # Availability Size / Price Qty
213-ILB-025/CF
213-ILB-01MG/CF
213-ILB-100/CF

With Carrier

Catalog # Availability Size / Price Qty
213-ILB-025
213-ILB-100
213-ILB-010
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Recombinant Human IL‑13 Protein SEC-MALS.
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Product Details
Citations (126)
FAQs
Reviews (10)

Recombinant Human IL-13 Protein Summary

Product Specifications

Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED50 for this effect is 0.5-2.5 ng/mL.
Source
E. coli-derived human IL-13 protein
Gly21-Asn132
Accession #
N-terminal Sequence
Analysis
Gly21
Predicted Molecular Mass
12.3 kDa
SDS-PAGE
9 kDa, reducing conditions

Product Datasheets

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213-ILB (with carrier)

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213-ILB/CF (carrier free)

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

213-ILB

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

213-ILB/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 100 μg/mL in PBS.
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

SEC-MALS View Larger

Recombinant Human IL-13 Protein (Catalog # 213-ILB) has a molecular weight (MW) of 12.0 kDa as analyzed by SEC-MALS, suggesting that this protein is a monomer.

Bioactivity Graph showing dose-dependent bioactivity of Human IL-13 protein View Larger

Recombinant human IL-13 (213-ILB) stimulates proliferation in the TF-1 human erythroleukemic cell line. The ED50 for this effect is 0.5-2.5 ng/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IL-13

Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells (1‑3). Mature human IL-13 shares approximately 58% amino acid sequence identity with mouse and rat IL-13. Despite the low homology, it exhibits cross‑species activity between human, mouse, and rat (4). IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances by macrophages, fibroblasts, and endothelial cells. On B cells, it promotes cellular activation, immunoglobulin class switching to IgE, and the up‑regulation of CD23/Fc epsilon RII (1, 5). IL-13 binds with low affinity to the transmembrane IL-13 R alpha 1 which then forms a signaling complex with the transmembrane IL-4 R alpha (6‑8). This high affinity receptor complex also functions as the type 2 IL-4 receptor (6, 7). IL‑13 R alpha 2 inhibits responses to both IL-13 and IL-4. It binds IL-13 with high affinity (9, 10) and prevents IL-13 from signaling through the IL-13 R alpha 1/IL-4 R alpha complex (11, 12). It also blocks signaling through IL-4-occupied IL-13 R alpha 1/IL-4 R alpha receptor complexes (12, 13). In addition, IL-13-bound IL-13 R alpha 2 can directly promote tumor cell invasiveness and the development of tissue fibrosis (14‑16).

References
  1. Saggini, A. et al. (2011) Int. J. Immunopathol. Pharmacol. 24:305.
  2. Gallo, E. et al. (2012) Eur. J. Immunol. 42:2322.
  3. Liang, H.E. et al. (2012) Nat. Immunol. 13:58.
  4. Ruetten, H. and C. Thiemermann (1997) Shock 8:409.
  5. McKenzie, A.N. et al. (1993) Proc. Natl. Acad. Sci. USA 90:3735.
  6. Aman, M.J. et al. (1996) J. Biol. Chem. 271:29265.
  7. Zurawski, S.M. et al. (1995) J. Biol. Chem. 270:13869.
  8. Andrews, A.L. et al. (2002) J. Biol. Chem. 277:46073.
  9. Chen, W. et al. (2009) J. Immunol. 183:7870.
  10. Daines, M.O. et al. (2007) J. Allergy Clin. Immunol. 119:375.
  11. Kasaian, M.T. et al. (2011) J. Immunol. 187:561.
  12. Andrews, A.-L. et al. (2006) J. Allergy Clin. Immunol. 118:858.
  13. Rahaman, S.O. et al. (2002) Cancer Res. 62:1103.
  14. Fujisawa, T. et al. (2009) Cancer Res. 69:8678.
  15. Fujisawa, T. et al. (2011) Int. J. Cancer 131:344.
  16. Fichtner-Feigl, S. et al. (2006) Nat. Med. 12:99.
Long Name
Interleukin 13
Entrez Gene IDs
3596 (Human); 16163 (Mouse); 116553 (Rat); 574325 (Primate)
Alternate Names
ALRHMGC116789; BHR1interleukin-13; IL13; IL-13; IL-13MGC116788; interleukin 13; MGC116786; NC30; P600

Citations for Recombinant Human IL-13 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

126 Citations: Showing 1 - 10
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  1. Investigation into the role of the MITA-TRIM38 interaction in regulating pyroptosis and maintaining immune tolerance at the maternal-fetal interface
    Authors: Liu, J;Deng, Y;Wang, A;Liu, B;Zhou, X;Yin, T;Wang, Y;Tang, T;Qiu, Y;Chen, J;Yang, J;
    Cell death & disease
    Species: Human
    Sample Types: Transduced Whole Cells, Whole Cells
    Applications: Bioassay
  2. Maimendong decoction regulates M2 macrophage polarization to suppress pulmonary fibrosis via PI3K/Akt/FOXO3a signalling pathway-mediated fibroblast activation
    Authors: Shuangshuang, H;Mengmeng, S;Lan, Z;Fang, Z;Yu, L;
    Journal of ethnopharmacology
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Influence of Macrophages on Vascular Invasion of Inflammatory Breast Cancer Emboli Measured Using an In Vitro Microfluidic Multi-Cellular Platform
    Authors: Gadde, M;Mehrabi-Dehdezi, M;Debeb, BG;Woodward, WA;Rylander, MN;
    Cancers
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Comprehensive analysis of E47?like factors and verification of ELF4 in clear cell renal cell carcinoma
    Authors: Lu, J;Zhang, Q;Mo, L;Chen, W;Mao, L;
    Oncology letters
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. CellSNAP: A fast, accurate algorithm for 3D cell segmentation in quantitative phase imaging
    Authors: Raj, P;Paidi, S;Conway, L;Chatterjee, A;Barman, I;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Enhanced powder dispersion of dual-excipient spray-dried powder formulations of a monoclonal antibody and its fragment for local treatment of severe asthma
    Authors: Pan, HW;Guo, J;Zhu, L;Leung, SWS;Zhang, C;Lam, JKW;
    International journal of pharmaceutics
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. TRAIP serves as a potential prognostic biomarker and correlates with immune infiltrates in lung adenocarcinoma
    Authors: Jing, Y;Mao, Z;Zhu, J;Ma, X;Liu, H;Chen, F;
    International immunopharmacology
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Targeting Glioblastoma-Associated Macrophages for Photodynamic Therapy Using AGuIX�-Design Nanoparticles
    Authors: L Lerouge, M Gries, A Chateau, J Daouk, F Lux, P Rocchi, J Cedervall, AK Olsson, O Tillement, C Frochot, S Acherar, N Thomas, M Barberi-He
    Pharmaceutics, 2023-03-20;15(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Light-sheet laser speckle imaging for cilia motility assessment
    Authors: K Long, J Liu, S Shen, M Thong, D Wang, N Chen
    Computational and structural biotechnology journal, 2023-02-20;21(0):1661-1669.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Induction of type II collagen expression in M2 macrophages derived from peripheral blood mononuclear cells
    Authors: FH Wang, CY Hsieh, CI Shen, CH Chuang, YH Chung, CC Kuo, KD Lee, CL Lin, HL Su
    Scientific Reports, 2022-12-15;12(1):21663.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Decreased Innate Migration of Pro-Inflammatory M1 Macrophages through the Mesothelial Membrane Is Affected by Ceramide Kinase and Ceramide 1-P
    Authors: CW Ku, J Yang, HY Tan, JKY Chan, YH Lee
    International Journal of Molecular Sciences, 2022-12-15;23(24):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Polarization
  12. EMR1/ADGRE1 Expression in Cancer Cells Upregulated by Tumor-Associated Macrophages Is Related to Poor Prognosis in Colorectal Cancer
    Authors: R Akter, K Kim, HY Kwon, Y Kim, YW Eom, HM Cho, MY Cho
    Biomedicines, 2022-12-02;10(12):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  13. Netrin-1 Promotes Visceral Adipose Tissue Inflammation in Obesity and Is Associated with Insulin Resistance
    Authors: A Mentxaka, J Gómez-Ambr, B Ramírez, A Rodríguez, S Becerril, G Neira, V Valentí, R Moncada, C Silva, X Unamuno, JA Cienfuegos, J Escalada, G Frühbeck, V Catalán
    Nutrients, 2022-10-18;14(20):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  14. S100A8-mediated metabolic adaptation controls HIV-1 persistence in macrophages in vivo
    Authors: F Real, A Zhu, B Huang, A Belmellat, A Sennepin, T Vogl, C Ransy, M Revol, R Arrigucci, A Lombès, J Roth, ML Gennaro, F Bouillaud, S Cristofari, M Bomsel
    Nature Communications, 2022-10-11;13(1):5956.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target
    Authors: H Cho, HY Kwon, A Sharma, SH Lee, X Liu, N Miyamoto, JJ Kim, SH Im, NY Kang, YT Chang
    Nature Communications, 2022-10-10;13(1):5974.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Cytokine responsive networks in human colonic epithelial organoids unveil a molecular classification of inflammatory bowel disease
    Authors: P Pavlidis, A Tsakmaki, A Treveil, K Li, D Cozzetto, F Yang, U Niazi, BH Hayee, M Saqi, J Friedman, T Korcsmaros, G Bewick, N Powell
    Cell Reports, 2022-09-27;40(13):111439.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  17. Dermatopontin Influences the Development of Obesity-Associated Colon Cancer by Changes in the Expression of Extracellular Matrix Proteins
    Authors: V Catalán, P Domench, J Gómez-Ambr, B Ramírez, S Becerril, A Mentxaka, A Rodríguez, V Valentí, R Moncada, J Baixauli, C Silva, J Escalada, G Frühbeck
    International Journal of Molecular Sciences, 2022-08-17;23(16):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Stimulation
  18. Enhanced In Vitro Expression of Filaggrin and Antimicrobial Peptides Following Application of Glycosaminoglycans and a Sphingomyelin-Rich Lipid Extract
    Authors: S Segarra, T Naiken, J Garnier, V Hamon, N Coussay, FX Bernard
    Oncogene, 2022-06-27;9(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. CD206+ tumor-associated macrophages cross-present tumor antigen and drive anti-tumor immunity
    Authors: M Modak, AK Mattes, D Reiss, W Skronska-W, R Langlois, N Sabarth, R Konopitzky, F Ramírez, K Lehr, T Mayr, D Kind, C Viollet, LK Swee, J Petschenka, KC El Kasmi, E Noessner, K Kitt, S Pflanz
    JCI Insight, 2022-06-08;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Preferential stimulation of melanocytes by M2 macrophages to produce melanin through vascular endothelial growth factor
    Authors: H Han, Y Kim, H Mo, SH Choi, K Lee, YA Rim, JH Ju
    Scientific Reports, 2022-04-19;12(1):6416.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Elevated Serum Leptin Levels in Patients With Eosinophilic Chronic Rhinosinusitis
    Authors: Y Imoto, S Ueki, Y Kato, K Yoshida, T Morikawa, Y Kimura, M Kidoguchi, T Tsutsumiuc, K Koyama, N Adachi, Y Ito, K Ogi, M Sakashita, T Yamada, RP Schleimer, T Takabayash, S Fujieda
    Frontiers in Pharmacology, 2022-01-03;12(0):793607.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Development of a potent high-affinity human therapeutic antibody via novel application of Recombination Signal Sequence (RSS)-based Affinity Maturation
    Authors: A Kielczewsk, I D'Angelo, MS Amador, T Wang, A Sudom, X Min, P Rathanaswa, C Pigott, IN Foltz
    The Journal of Biological Chemistry, 2021-12-29;0(0):101533.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  23. TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment
    Authors: E Kim, H Um, J Park, JW Jung, JE Kim, H Lee, EA Shin, Y Pinanga, H Lee, SH Nam, JW Lee
    Cell Reports, 2021-11-16;37(7):110018.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Bee Venom Prevents Mucin 5AC Production through Inhibition of AKT and SPDEF Activation in Airway Epithelia Cells
    Authors: S Kim, HW Kim, SH Chang, KH Leem, HJ Park
    Toxins, 2021-11-01;13(11):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris
    Authors: S Shao, J Chen, WR Swindell, LC Tsoi, X Xing, F Ma, R Uppala, MK Sarkar, O Plazyo, AC Billi, R Wasikowski, KM Smith, P Honore, VE Scott, E Maverakis, JM Kahlenberg, G Wang, NL Ward, PW Harms, JE Gudjonsson
    JCI Insight, 2021-10-22;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Macrophage Polarization Related to Crystal Phases of Calcium Phosphate Biomaterials
    Authors: L Xiao, Y Shiwaku, R Hamai, K Tsuchiya, K Sasaki, O Suzuki
    International Journal of Molecular Sciences, 2021-10-19;22(20):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Polarization
  27. Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis
    Authors: A Kuzumi, A Yoshizaki, KM Matsuda, H Kotani, Y Norimatsu, M Fukayama, S Ebata, T Fukasawa, A Yoshizaki-, Y Asano, K Morikawa, Y Kazoe, K Mawatari, T Kitamori, S Sato
    Nature Communications, 2021-10-12;12(1):5947.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. IL-13 acts directly on gastric epithelial cells to promote metaplasia development during chronic gastritis
    Authors: CN Noto, SG Hoft, KA Bockerstet, NM Jackson, EL Ford, LS Vest, RJ DiPaolo
    Cellular and Molecular Gastroenterology and Hepatology, 2021-09-26;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  29. Decreased Levels of Microfibril-Associated Glycoprotein (MAGP)-1 in Patients with Colon Cancer and Obesity Are Associated with Changes in Extracellular Matrix Remodelling
    Authors: I Gómez de S, P Ahechu, J Gómez-Ambr, A Rodríguez, B Ramírez, S Becerril, X Unamuno, A Mentxaka, J Baixauli, V Valentí, R Moncada, C Silva, G Frühbeck, V Catalán
    International Journal of Molecular Sciences, 2021-08-06;22(16):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Remodeling of bronchial epithelium caused by asthmatic inflammation affects its response to rhinovirus infection
    Authors: B Jakiela, A Rebane, J Soja, S Bazan-Soch, A Laanesoo, H Plutecka, M Surmiak, M Sanak, K Sladek, G Bochenek
    Scientific Reports, 2021-06-17;11(1):12821.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  31. Butyrate Alleviates Cytokine-Induced Barrier Dysfunction by Modifying Claudin-2 Levels
    Authors: X Huang, T Oshima, T Tomita, H Fukui, H Miwa
    Biology, 2021-03-09;10(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Butyrate and Propionate Restore the Cytokine and House Dust Mite Compromised Barrier Function of Human Bronchial Airway Epithelial Cells
    Authors: LB Richards, M Li, G Folkerts, PAJ Henricks, J Garssen, BCAM van Esch
    International Journal of Molecular Sciences, 2020-12-23;22(1):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. circARRDC3 contributes to interleukin?13?induced inflammatory cytokine and mucus production in nasal epithelial cells via the miR?375/KLF4 axis
    Authors: T Wang, P Wang, D Chen, Z Xu, L Yang
    Molecular Medicine Reports, 2020-12-14;23(2):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  34. Tumor-associated macrophage, angiogenesis and lymphangiogenesis markers predict prognosis of non-small cell lung cancer patients
    Authors: I Hwang, JW Kim, K Ylaya, EJ Chung, H Kitano, C Perry, J Hanaoka, J Fukuoka, JY Chung, SM Hewitt
    J Transl Med, 2020-11-23;18(1):443.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  35. Interleukin (IL)-25 suppresses IL-22-induced osteoclastogenesis in rheumatoid arthritis via STAT3 and p38 MAPK/I&kappaB&alpha pathway
    Authors: HK Min, JY Won, BM Kim, KA Lee, SJ Lee, SH Lee, HR Kim, KW Kim
    Arthritis Research & Therapy, 2020-09-23;22(1):222.
    Species: Human
    Sample Types: Reference Standard
  36. The use of patient-derived breast tissue explants to study macrophage polarization and the effects of environmental chemical exposure
    Authors: KJ Gregory, SM Morin, A Kubosiak, J Ser-Dolans, B Schalet, DJ Jerry, SS Schneider
    Immunol. Cell Biol., 2020-09-09;0(0):.
    Species: Human
    Sample Types: Whole Cell
    Applications: Cell Culture
  37. IL13Ralpha1 protects against rheumatoid arthritis by combating the apoptotic resistance of fibroblast-like synoviocytes
    Authors: X Yang, Q Guo, T Feng, Q Lu, L Ge, J Pan, K Bi, L Qiao, L Tian, T Xie, C Yao, G Song, L Wang
    Arthritis Res. Ther., 2020-08-08;22(1):184.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Ozone-derived oxysterols impair lung macrophage phagocytosis via adduction of some phagocytosis receptors
    Authors: PF Duffney, HH Kim, NA Porter, I Jaspers
    J. Biol. Chem., 2020-07-20;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  39. Anti-Cancer Activity of Acriflavine as Metabolic Inhibitor of OXPHOS in Pancreas Cancer Xenografts
    Authors: A Bulle, J Dekervel, L Deschutter, D Nittner, E Van Cutsem, C Verslype, J van Pelt
    Onco Targets Ther, 2020-07-15;13(0):6907-6916.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Single-Cell and Population Transcriptomics Reveal Pan-epithelial Remodeling in Type 2-High Asthma
    Authors: ND Jackson, JL Everman, M Chioccioli, L Feriani, KC Goldfarbmu, SP Sajuthi, CL Rios, R Powell, M Armstrong, J Gomez, C Michel, C Eng, SS Oh, J Rodriguez-, P Cicuta, N Reisdorph, EG Burchard, MA Seibold
    Cell Rep, 2020-07-07;32(1):107872.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  41. T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation
    Authors: J Yan, SP Pandey, BJ Barnes, JR Turner, C Abraham
    Cell Rep, 2020-06-30;31(13):107820.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Periostin and tenascin-C interaction promotes angiogenesis in ischemic proliferative retinopathy
    Authors: Y Kubo, K Ishikawa, K Mori, Y Kobayashi, T Nakama, M Arima, S Nakao, T Hisatomi, M Haruta, KH Sonoda, S Yoshida
    Sci Rep, 2020-06-09;10(1):9299.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins
    Authors: RA Lu, AA Zeki, S Ram-Mohan, N Nguyen, Y Bai, K Chmiel, S Pecic, X Ai, R Krishnan, CC Ghosh
    Front Pharmacol, 2020-05-06;11(0):469.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  44. Dermatopontin, A Novel Adipokine Promoting Adipose Tissue Extracellular Matrix Remodelling and Inflammation in Obesity
    Authors: X Unamuno, J Gómez-Ambr, B Ramírez, A Rodríguez, S Becerril, V Valentí, R Moncada, C Silva, J Salvador, G Frühbeck, V Catalán
    J Clin Med, 2020-04-09;9(4):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  45. HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment
    Authors: YD Kim, SM Park, HC Ha, AR Lee, H Won, H Cha, S Cho, JM Cho
    J Cancer, 2020-04-06;11(14):4059-4072.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Impacts of Intralipid on Nanodrug Abraxane Therapy and on the Innate Immune System
    Authors: YJ Chen, CY Tsai, YM Cheng, SW Nieh, TK Yeh, CP Chen, MH Wang, LH Chou, TY Chiu, L Liu, C Ho, CT Chen, TW Liu
    Sci Rep, 2020-02-18;10(1):2838.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  47. Cycling hypoxia promotes a pro-inflammatory phenotype in macrophages via JNK/p65 signaling pathway
    Authors: V Delprat, C Tellier, C Demazy, M Raes, O Feron, C Michiels
    Sci Rep, 2020-01-21;10(1):882.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. M2 Macrophages Promote HCC Cells Invasion and Migration via miR-149-5p/MMP9 Signaling
    Authors: G Liu, L Yin, X Ouyang, K Zeng, Y Xiao, Y Li
    J Cancer, 2020-01-01;11(5):1277-1287.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  49. Pancreatic cancer-derived small extracellular vesical Ezrin regulates macrophage polarization and promotes metastasis
    Authors: YT Chang, HY Peng, CM Hu, SC Huang, SC Tien, YM Jeng
    Am J Cancer Res, 2020-01-01;10(1):12-37.
    Species: Human
    Sample Types: Whole Cell
    Applications: Bioassay
  50. Linking the effects of helminth infection, diet and the gut microbiota with human whole-blood signatures
    Authors: SC Lee, MS Tang, AV Easton, JC Devlin, LL Chua, I Cho, FM Moy, TF Khang, YAL Lim, P Loke
    PLoS Pathog., 2019-12-16;15(12):e1008066.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  51. Alpha-linolenic acid enhances the phagocytic and secretory functions of alternatively activated macrophages in part via changes to the oxylipin profile
    Authors: SD Pauls, LA Rodway, T Winter, CG Taylor, P Zahradka, HM Aukema
    Int. J. Biochem. Cell Biol., 2019-12-04;119(0):105662.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
    Authors: N Berges, MS Nawaz, T Børresdatt, L Hagen, M Bjørås, JK Laerdahl, I Alseth
    PLoS ONE, 2019-11-08;14(11):e0225081.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  53. NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling
    Authors: X Unamuno, J Gómez-Ambr, B Ramírez, A Rodríguez, S Becerril, V Valentí, R Moncada, C Silva, J Salvador, G Frühbeck, V Catalán
    Cell. Mol. Immunol., 2019-09-24;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. IL-4 and IL-17A Cooperatively Promote Hydrogen Peroxide Production, Oxidative DNA Damage, and Upregulation of Dual Oxidase 2 in Human Colon and Pancreatic Cancer Cells
    Authors: Y Wu, MM Konaté, J Lu, H Makhlouf, R Chuaqui, S Antony, JL Meitzler, MJ Difilippan, H Liu, A Juhasz, G Jiang, I Dahan, K Roy, JH Doroshow
    J. Immunol., 2019-09-23;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. TNF-α and IL-17A induce the expression of lympho-epithelial Kazal-type inhibitor in epidermal keratinocytes
    Authors: S Sugihara, S Sugimoto, K Tachibana, M Kobashi, H Nomura, T Miyake, Y Hirai, O Yamasaki, S Morizane
    J. Dermatol. Sci., 2019-08-21;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  56. Boiling Histotripsy-induced Partial Mechanical Ablation Modulates Tumour Microenvironment by Promoting Immunogenic Cell Death of Cancers
    Authors: KJ Pahk, CH Shin, IY Bae, Y Yang, SH Kim, K Pahk, H Kim, SJ Oh
    Sci Rep, 2019-06-21;9(1):9050.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. The role of IL-36? and its regulation in eosinophilic inflammation in allergic rhinitis
    Authors: X Qin, M Liu, S Zhang, C Wang, T Zhang
    Cytokine, 2019-03-01;117(0):84-90.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Sodium channel TRPM4 and sodium/calcium exchangers (NCX) cooperate in the control of Ca2+-induced mucin secretion from goblet cells
    Authors: G Cantero-Re, CM Butnaru, N Brouwers, S Mitrovic, MA Valverde, V Malhotra
    J. Biol. Chem., 2018-11-27;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Tumor-associated macrophages derived CCL18 promotes metastasis in squamous cell carcinoma of the head and neck
    Authors: L She, Y Qin, J Wang, C Liu, G Zhu, G Li, M Wei, C Chen, G Liu, D Zhang, X Chen, Y Wang, Y Qiu, Y Tian, X Zhang, Y Liu, D Huang
    Cancer Cell Int., 2018-08-28;18(0):120.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Proton irradiation orchestrates macrophage reprogramming through NF?B signaling
    Authors: G Genard, AC Wera, C Huart, B Le Calve, S Penninckx, A Fattacciol, T Tabarrant, C Demazy, N Ninane, AC Heuskin, S Lucas, C Michiels
    Cell Death Dis, 2018-06-27;9(7):728.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. BET inhibition in advanced cutaneous T cell lymphoma is synergistically potentiated by BCL2 inhibition or HDAC inhibition
    Authors: SR Kim, JM Lewis, BM Cyrenne, PF Monico, FN Mirza, KR Carlson, FM Foss, M Girardi
    Oncotarget, 2018-06-26;9(49):29193-29207.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Effect of colorectal cancer-derived extracellular vesicles on the immunophenotype and cytokine secretion profile of monocytes and macrophages
    Authors: I Pop?na, A ?bols, L Saul?te, K Pleiko, E Zandberga, K J?kabsons, E Endzeli?š, A Llorente, A Lin?, U Rieksti?a
    Cell Commun. Signal, 2018-04-24;16(1):17.
    Species: Human
    Sample Types: Whole Cells
    Applications: Differentiation, Differentiation
  63. IL-13 induces periostin and eotaxin expression in human primary alveolar epithelial cells: Comparison with paired airway epithelial cells
    Authors: Y Ito, R Al Mubarak, N Roberts, K Correll, W Janssen, J Finigan, R Mishra, HW Chu
    PLoS ONE, 2018-04-19;13(4):e0196256.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Carcinoembryonic antigen as a marker of radioresistance in colorectal cancer: a potential role of macrophages
    Authors: EY Huang, JC Chang, HH Chen, CY Hsu, HC Hsu, KL Wu
    BMC Cancer, 2018-03-27;18(1):321.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. TNFSF14 (LIGHT) Exhibits Inflammatory Activities in Lung Fibroblasts Complementary to IL-13 and TGF-β
    Authors: R da Silva A, AK Mehta, L Madge, J Tocker, M Croft
    Front Immunol, 2018-03-19;9(0):576.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  66. Lipid abnormalities in atopic skin are driven by type 2 cytokines
    Authors: E Berdyshev, E Goleva, I Bronova, N Dyjack, C Rios, J Jung, P Taylor, M Jeong, CF Hall, BN Richers, KA Norquest, T Zheng, MA Seibold, DY Leung
    JCI Insight, 2018-02-22;3(4):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  67. MicroRNA-31 and MicroRNA-155 Are Overexpressed in Ulcerative Colitis and Regulate IL-13 Signaling by Targeting Interleukin 13 Receptor ?-1
    Authors: M Gwiggner, RT Martinez-N, SR Whiteoak, VP Bondanese, A Claridge, JE Collins, JRF Cummings, T Sanchez-El
    Genes (Basel), 2018-02-13;9(2):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis
    Authors: R Bruen, S Curley, S Kajani, D Crean, ME O'Reilly, MB Lucitt, CG Godson, FC McGillicud, O Belton
    Cardiovasc Diabetol, 2017-11-06;16(1):143.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression
    Authors: Y Wang, JB Mumm, R Herbst, R Kolbeck, Y Wang
    J. Immunol., 2017-09-22;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  70. GATA3 regulates FLG and FLG2 expression in human primary keratinocytes
    Authors: J Zeitvogel, N Jokmin, S Rieker, I Klug, C Brandenber, T Werfel
    Sci Rep, 2017-09-19;7(1):11847.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Pulmonary microRNA profiles identify involvement of Creb1 and Sec14l3 in bronchial epithelial changes in allergic asthma
    Authors: S Bartel, N Schulz, F Alessandri, AC Schamberge, P Pagel, FJ Theis, K Milger, E Noessner, SM Stick, A Kicic, O Eickelberg, RJ Freishtat, S Krauss-Ets
    Sci Rep, 2017-04-06;7(0):46026.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Interferon-? induced insufficient autophagy contributes to p62-dependent apoptosis of epithelial cells in chronic rhinosinusitis with nasal polyps
    Authors: BF Wang, PP Cao, ZC Wang, ZY Li, ZZ Wang, J Ma, B Liao, YK Deng, XB Long, K Xu, H Wang, H Wang, M Zeng, X Lu, Z Liu
    Allergy, 2017-04-04;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Therapeutic Effect of Novel Single-Stranded RNAi Agent Targeting Periostin in Eyes with Retinal Neovascularization
    Authors: T Nakama, S Yoshida, K Ishikawa, Y Kubo, Y Kobayashi, Y Zhou, S Nakao, T Hisatomi, Y Ikeda, K Takao, K Yoshikawa, A Matsuda, J Ono, S Ohta, K Izuhara, A Kudo, KH Sonoda, T Ishibashi
    Mol Ther Nucleic Acids, 2017-02-09;6(0):279-289.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Development of Combining of Human Bronchial Mucosa Models with XposeALI? for Exposure of Air Pollution Nanoparticles
    Authors: J Ji, A Hedelin, M Malml”f, V Kessler, G Seisenbaev, P Gerde, L Palmberg
    PLoS ONE, 2017-01-20;12(1):e0170428.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Structural Characterisation Reveals Mechanism of IL-13 Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13R?1 and IL-13R?2
    Authors: B Popovic
    J. Mol. Biol, 2016-12-09;0(0):.
    Applications: Bioassay
  76. Classical and alternative macrophages have impaired function during acute and chronic HIV-1 infection
    Authors: Leonardo J Galvão-Lim
    Braz J Infect Dis, 2016-11-29;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Anti-inflammatory and immunomodulatory effects of Aquaphilus dolomiae extract on in vitro models
    Authors: Nathalie Castex-Riz
    Clin Cosmet Investig Dermatol, 2016-11-10;9(0):421-434.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Increased Interleukin-32 Levels in Obesity Promote Adipose Tissue Inflammation and Extracellular Matrix Remodeling: Effect of Weight Loss
    Authors: Victoria Catalán
    Diabetes, 2016-09-14;65(12):3636-3648.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Thymic stromal chemokine TSLP acts through Th2 cytokine production to induce cutaneous T cell lymphoma
    Cancer Res, 2016-09-06;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  80. JAK-STAT6 Pathway Inhibitors Block Eotaxin-3 Secretion by Epithelial Cells and Fibroblasts from Esophageal Eosinophilia Patients: Promising Agents to Improve Inflammation and Prevent Fibrosis in EoE
    Authors: Edaire Cheng
    PLoS ONE, 2016-06-16;11(6):e0157376.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  81. IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics
    Authors: S O'Reilly, M Ciechomska, N Fullard, S Przyborski, JM van Laar
    Sci Rep, 2016-04-26;6(0):25066.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Long-Acting Beta Agonists Enhance Allergic Airway Disease.
    Authors: Knight J, Mak G, Shaw J, Porter P, McDermott C, Roberts L, You R, Yuan X, Millien V, Qian Y, Song L, Frazier V, Kim C, Kim J, Bond R, Milner J, Zhang Y, Mandal P, Luong A, Kheradmand F, McMurray J, Corry D
    PLoS ONE, 2015-11-25;10(11):e0142212.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  83. An Allergic Lung Microenvironment Suppresses Carbon Nanotube-Induced Inflammasome Activation via STAT6-Dependent Inhibition of Caspase-1.
    Authors: Shipkowski K, Taylor A, Thompson E, Glista-Baker E, Sayers B, Messenger Z, Bauer R, Jaspers I, Bonner J
    PLoS ONE, 2015-06-19;10(6):e0128888.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  84. Vinpocetine inhibits Streptococcus pneumoniae-induced upregulation of mucin MUC5AC expression via induction of MKP-1 phosphatase in the pathogenesis of otitis media.
    Authors: Lee J, Komatsu K, Lee B, Miyata M, O'Neill Bohn A, Xu H, Yan C, Li J
    J Immunol, 2015-05-13;194(12):5990-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  85. IL-25 induces airways angiogenesis and expression of multiple angiogenic factors in a murine asthma model.
    Authors: Yao, Xiujuan, Wang, Wei, Li, Yan, Huang, Ping, Zhang, Qian, Wang, Jingjing, Wang, Wen, Lv, Zhe, An, Yunqing, Qin, Jianguo, Corrigan, Chris J, Huang, Kewu, Sun, Yongchan, Ying, Sun
    Respir Res, 2015-03-18;16(0):39.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  86. SOCS3 silencing attenuates eosinophil functions in asthma patients.
    Authors: Zafra M, Canas J, Mazzeo C, Gamez C, Sanz V, Fernandez-Nieto M, Quirce S, Barranco P, Ruiz-Hornillos J, Sastre J, del Pozo V
    Int J Mol Sci, 2015-03-10;16(3):5434-51.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Expression of surfactant protein D in airways of asthmatics and interleukin-13 modulation of surfactant protein D in human models of airway epithelium.
    Authors: Xu J, Singhera G, Dorscheid D
    Respir Res, 2015-02-15;16(0):26.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  88. Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M.
    Authors: Kwofie K, Scott M, Rodrigues R, Guerette J, Radford K, Nair P, Richards C
    Respir Res, 2015-02-07;16(0):14.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  89. ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages.
    Authors: Herova M, Schmid M, Gemperle C, Hersberger M
    J Immunol, 2015-01-30;194(5):2330-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  90. IL-27 and type 2 immunity in asthmatic patients: association with severity, CXCL9, and signal transducer and activator of transcription signaling.
    Authors: Xie M, Mustovich A, Jiang Y, Trudeau J, Ray A, Ray P, Hu H, Holguin F, Freeman B, Wenzel S
    J Allergy Clin Immunol, 2014-10-11;135(2):386-94.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  91. Origin of myofibroblasts in the fibrotic liver in mice.
    Authors: Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris T, Park T, Liu X, Xu J, Wang P, Paik Y, Meng F, Asagiri M, Murray L, Hofmann A, Iida T, Glass C, Brenner D, Kisseleva T
    Proc Natl Acad Sci U S A, 2014-07-29;111(32):E3297-305.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  92. Proton pump inhibitors decrease eotaxin-3 expression in the proximal esophagus of children with esophageal eosinophilia.
    Authors: Park, Jason Y, Zhang, Xi, Nguyen, Nathalie, Souza, Rhonda F, Spechler, Stuart J, Cheng, Edaire
    PLoS ONE, 2014-07-02;9(7):e101391.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  93. A thymic stromal lymphopoietin-responsive dendritic cell subset mediates allergic responses in the upper airway mucosa.
    Authors: Melum G, Farkas L, Scheel C, Van Dieren B, Gran E, Liu Y, Johansen F, Jahnsen F, Baekkevold E
    J Allergy Clin Immunol, 2014-06-21;134(3):613-621.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  94. IL-33 stimulates CXCL8/IL-8 secretion in goblet cells but not normally differentiated airway cells.
    Authors: Tanabe T, Shimokawaji T, Kanoh S, Rubin B
    Clin Exp Allergy, 2014-04-01;44(4):540-52.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  95. An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma.
    Authors: Voraphani N, Gladwin M, Contreras A, Kaminski N, Tedrow J, Milosevic J, Bleecker E, Meyers D, Ray A, Ray P, Erzurum S, Busse W, Zhao J, Trudeau J, Wenzel S
    Mucosal Immunol, 2014-02-12;7(5):1175-85.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  96. Absence of a role for interleukin-13 in inflammatory bowel disease.
    Authors: Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, Hoque S, Ghanbari A, Joe-Njoku I, Giuffrida P, Rovedatti L, Geginat J, Corazza G, MacDonald T
    Eur J Immunol, 2014-02-01;44(2):370-85.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy.
    Authors: Ahmad T, Mukherjee S, Pattnaik B, Kumar M, Singh S, Kumar M, Rehman R, Tiwari B, Jha K, Barhanpurkar A, Wani M, Roy S, Mabalirajan U, Ghosh B, Agrawal A
    EMBO J, 2014-01-15;33(9):994-1010.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  98. Conditioned media from macrophages of M1, but not M2 phenotype, inhibit the proliferation of the colon cancer cell lines HT-29 and CACO-2.
    Authors: Engstrom A, Erlandsson A, Delbro D, Wijkander J
    Int J Oncol, 2013-12-02;44(2):385-92.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Possible new therapeutic strategy to regulate atopic dermatitis through upregulating filaggrin expression.
    Authors: Otsuka A, Doi H, Egawa G, Maekawa A, Fujita T, Nakamizo S, Nakashima C, Nakajima S, Watanabe T, Miyachi Y, Narumiya S, Kabashima K
    J Allergy Clin Immunol, 2013-09-20;133(1):139-46.e1-10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  100. Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.
    Authors: Pellerin L, Henry J, Hsu C, Balica S, Jean-Decoster C, Mechin M, Hansmann B, Rodriguez E, Weindinger S, Schmitt A, Serre G, Paul C, Simon M
    J Allergy Clin Immunol, 2013-02-10;131(4):1094-102.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  101. 12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma.
    Authors: Mabalirajan U, Rehman R, Ahmad T, Kumar S, Leishangthem G, Singh S, Dinda A, Biswal S, Agrawal A, Ghosh B
    Sci Rep, 2013-01-01;3(0):1540.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  102. Regulation of the formyl peptide receptor 1 (FPR1) gene in primary human macrophages.
    Authors: Gemperle C, Schmid M, Herova M, Marti-Jaun J, Wuest S, Loretz C, Hersberger M
    PLoS ONE, 2012-11-21;7(11):e50195.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  103. IL-26 Is Overexpressed in Rheumatoid Arthritis and Induces Proinflammatory Cytokine Production and Th17 Cell Generation.
    Authors: Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, Hoppe E, Barre B, Audran M, Bouvard B, Saint-Andre J, Jeannin P
    PLoS Biol, 2012-09-25;10(9):e1001395.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  104. Pentraxin 3 (PTX3) expression in allergic asthmatic airways: role in airway smooth muscle migration and chemokine production.
    Authors: Zhang J, Shan L, Koussih L, Redhu NS, Halayko AJ, Chakir J, Gounni AS
    PLoS ONE, 2012-04-18;7(4):e34965.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  105. Expression and regulation of CCL15 by human airway smooth muscle cells.
    Authors: Joubert P, Lajoie-Kadoch S, Wellemans V, Létuvé S, Tulic MK, Halayko AJ, Hamid Q
    Clin. Exp. Allergy, 2011-11-09;42(1):85-94.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  106. Epigenetic modulation enhances the therapeutic effect of anti-IL-13R alpha2 antibody in human mesothelioma xenografts.
    Clin. Cancer Res., 2011-02-28;17(9):2819-29.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  107. Inhibition of double-stranded RNA-induced TSLP in human keratinocytes by glucocorticoids.
    Authors: Le TA, Takai T, Kinoshita H, Suto H, Ikeda S, Okumura K, Ogawa H
    Allergy, 2009-03-27;64(8):1231-2.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  108. Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines.
    Authors: Ma P, Bian F, Wang Z, Zheng X, Chotikavanich S, Pflugfelder SC, Li DQ
    Invest. Ophthalmol. Vis. Sci., 2009-01-17;50(6):2702-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  109. IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response.
    Authors: Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A
    J. Allergy Clin. Immunol., 2008-12-03;123(1):59-66.e4.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  110. Divergent effects of hypoxia on dendritic cell functions.
    Authors: Mancino A, Schioppa T, Larghi P, Pasqualini F, Nebuloni M, Chen IH, Sozzani S, Austyn JM, Mantovani A, Sica A
    Blood, 2008-08-11;112(9):3723-34.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  111. Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps.
    Authors: Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R, Conley D, Grammer LC, Kern R, Schleimer RP
    J. Allergy Clin. Immunol., 2008-04-14;121(6):1385-92, 1392.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  112. Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells.
    Authors: Liu TY, Uemura Y, Suzuki M, Narita Y, Hirata S, Ohyama H, Ishihara O, Matsushita S
    Eur. J. Immunol., 2008-04-01;38(4):1012-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  113. Development of an in vitro potency bioassay for therapeutic IL-13 antagonists: the A-549 cell bioassay.
    Authors: Miller R, Sadhukhan R, Wu C
    J. Immunol. Methods, 2008-03-07;334(1):134-41.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  114. Expression and regulation of CCR1 by airway smooth muscle cells in asthma.
    Authors: Joubert P, Lajoie-Kadoch S, Welman M, Dragon S, Letuvee S, Tolloczko B, Halayko AJ, Gounni AS, Maghni K, Hamid Q
    J. Immunol., 2008-01-15;180(2):1268-75.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  115. TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells.
    Authors: Kato A, Favoreto S, Avila PC, Schleimer RP
    J. Immunol., 2007-07-15;179(2):1080-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  116. Allergic airway inflammation inhibits pulmonary antibacterial host defense.
    Authors: Beisswenger C, Kandler K, Hess C, Garn H, Felgentreff K, Wegmann M, Renz H, Vogelmeier C, Bals R
    J. Immunol., 2006-08-01;177(3):1833-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  117. Cigarette smoke synergistically enhances respiratory mucin induction by proinflammatory stimuli.
    Authors: Baginski TK, Dabbagh K, Satjawatcharaphong C, Swinney DC
    Am. J. Respir. Cell Mol. Biol., 2006-03-16;35(2):165-74.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus.
    Authors: Howell MD, Gallo RL, Boguniewicz M, Jones JF, Wong C, Streib JE, Leung DY
    Immunity, 2006-03-01;24(3):341-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  119. Th2 cytokine response in Major Depressive Disorder patients before treatment.
    Authors: Kiryushko D, Pavon L, Novitskaya V, Sandoval-Lopez G, Soroka V, Eugenia Hernandez M, Klingelhofer J, Loria F, Lukanidin E, Estrada I, Berezin V, Perez M, Bock E, Moreno J, Avila U, Leff P, Anton B, Heinze G
    J. Neuroimmunol., 2006-02-02;172(1):156-65.
    Applications: ELISA (Standard)
  120. Protection of human conjunctival fibroblasts from NO-induced apoptosis by interleukin-4 or interleukin-13.
    Authors: Fujitsu Y, Fukuda K, Kimura K, Seki K, Kumagai N, Nishida T
    Invest. Ophthalmol. Vis. Sci., 2005-03-01;46(3):797-802.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells.
    Authors: Kahlon KS, Brown C, Cooper LJ, Raubitschek A, Forman SJ, Jensen MC
    Cancer Res., 2004-12-15;64(24):9160-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  122. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways.
    Authors: Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R
    J. Immunol., 2004-09-01;173(5):3482-91.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  123. Differential effect of IL-4 and IL-13 on the expression of recombination-activating genes in mature B cells from human peripheral blood.
    Authors: Kajiwara K, Shinazawa M, Morishima H, Yanagihara Y
    Cell. Immunol., 2004-02-01;227(2):121-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  124. Production of interleukin-13 by human dendritic cells after stimulation with protein allergens is a key factor for induction of T helper 2 cytokines and is associated with activation of signal transducer and activator of transcription-6.
    Authors: Bellinghausen I, Brand P, Bottcher I, Klostermann B, Knop J, Saloga J
    Immunology, 2003-02-01;108(2):167-76.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  125. Eosinophils express functional IL-13 in eosinophilic inflammatory diseases.
    Authors: Schmid-Grendelmeier P, Altznauer F, Fischer B, Bizer C, Straumann A, Menz G, Blaser K, Wuthrich B, Simon HU
    J. Immunol., 2002-07-15;169(2):1021-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  126. Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells.
    Authors: Liu X, Kohyama T, Wang H, Zhu YK, Wen FQ, Kim HJ, Romberger DJ, Rennard SI
    Am. J. Physiol. Lung Cell Mol. Physiol., 2002-05-01;282(5):L1049-56.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

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Reviews for Recombinant Human IL-13 Protein

Average Rating: 4.9 (Based on 10 Reviews)

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Recombinant Human IL-13 Protein
By Anonymous on 08/03/2022
Application: Stem/Immune cell maintenance or differentiation

Downregulation of a given gene after IL-13 exposure detected by qPCR. Three independent experiments.


Recombinant Human IL-13 Protein
By Anonymous on 08/03/2022
Application: Flow
Reason for Rating: Great responses after IL-13 exposure by flow cytometry

Control vs. rIL-13 for 6h


Recombinant Human IL-13 Protein
By Anonymous on 08/03/2022
Application: In vitro bioactivity in cell culture
Reason for Rating: Highly recommended!

Detecting target protein expression after 12h
1. Control
2. +10ng/mL IL-13


Recombinant Human IL-13 Protein
By Anonymous on 12/05/2021
Application: Cell adherence junction integrity
Reason for Rating: Human Il-13 was tested for its effect on adherence junction (yellow) integrity in ECs.

Recombinant Human IL-13 Protein
By Anonymous on 08/30/2019
Application: Cell migration/motility

Recombinant Human IL-13 Protein
By Anonymous on 08/16/2019
Application: In vitro bioactivity in cell culture
Reason for Rating: Worked greatly in human PBMC assay

Recombinant Human IL-13 Protein
By Anonymous on 06/09/2019
Application: In vitro bioactivity in cell culture
Reason for Rating: Cells supplied with 20ng/ml IL-4 and 100ng/ml of GM-CSF to differentiate dendritic cells

Recombinant Human IL-13 Protein
By Anonymous on 11/16/2018
Application: CellProlif
Reason for Rating: Cells were supplied with the cytokinetreatments: 50 ng /ml GM-CSF and 10 ng/ ml1 of IL-13 to differentiate DC cells

Recombinant Human IL-13 Protein
By Danlee Enzler on 04/02/2018
Application: In vitro bioactivity in cell culture

Recombinant Human IL-13 Protein
By Anonymous on 01/20/2016
Application: In vitro bioactivity in cell culture
Reason for Rating: IL-13 is a known to phosphorylate STAT-6. In my experiment, fibroblast cells were incubated for 30min and 4hr with IL-13 and then STAT-6 phosphorylation was measured via western blot. IL-13 phosphorylated STAT-6 as expected.