Recombinant Human RELT/TNFRSF19L Fc Chimera Protein, CF

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R&D Systems Recombinant Proteins and Enzymes
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Product Details

Recombinant Human RELT/TNFRSF19L Fc Chimera Protein, CF Summary

Product Specifications

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Bioassay data are not available.
Mouse myeloma cell line, NS0-derived human RELT/TNFRSF19L protein
Human RELT
Ser26-Ala160 (Arg127Gly and Arg129Gly)
Accession #Q969Z4
N-terminus C-terminus
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
41 kDa (monomer)
55-58 kDa, reducing conditions

Product Datasheets

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Supplied as a 0.2 μm filtered solution in PBS.
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after opening.
  • 3 months, -20 to -70 °C under sterile conditions after opening.
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Background: RELT/TNFRSF19L

RELT (Receptor Expressed in Lymphoid Tissues) is a 46 kDa (predicted) type I transmembrane glycoprotein belonging to the tumor necrosis factor receptor superfamily, designated TNFRSF19-like (TNFRSF19L) (1, 2). It is primarily expressed in hematopoietic tissues and peripheral blood leukocytes (2, 3). Human RELT cDNA encodes 430 amino acids (aa), including a 25 aa signal peptide, a 137 aa extracellular domain containing a TNF receptor cysteine-rich domain and a potential N‑linked glycosylation site, a 21 aa transmembrane domain and a 247 aa cytoplasmic region that lacks a death domain. Within the ECD, human RELT shares 78%, 75%, 75%, 78% and 72% aa sequence homology with mouse, rat, canine, porcine and bovine RELT, respectively. Among TNFRSF members, the RELT extracellular domain is most closely related to that of TROY/TNFRSF19 and OX40 (2). Neither human nor mouse RELT bind any of the ~19 TNF superfamily ligands that have been tested (1). Two related transmembrane proteins, RELL1 and RELL2, have been identified in both human and mouse (3). RELL1 and 2 can interact with and are coexpressed with RELT, and are thought to modulate its signaling (3-5). Intracellularly, RELT has been shown to bind the adaptor protein TRAF-1 and activate the NF‑ kappa B pathway, the phospholipid scramblase PLSCR1, and oxidative stress responsive proteins OSR1 (2-5). Another investigator notes association and signaling through SPAK, but not TRAF or NF kappa B (6). When overexpressed in HEK-293 cells, RELT induces p38 and JNK signaling and activates apoptosis (4-6). Immobilized RELT can also costimulate T-cell proliferation in the presence of CD3 signaling (2).

  1. Bossen C. et al. (2006) J. Biol. Chem. 281:13964.
  2. Sica, G. et al. (2001) Blood 97:2702.
  3. Cusick, J.K. et al. (2006) Biochem. Biophys. Res. Commun. 340:535.
  4. Cusick, J.K. et al. (2010) Cell. Immunol. 261:1.
  5. Cusick, J.K. et al. (2012) Mol. Cell. Biochem. 362:55.
  6. Polek T.C. et al. (2006) Biochem. Biophys. Res. Commun. 343:125.
Long Name
Receptor Expressed in Lymphoid Tissues
Entrez Gene IDs
84957 (Human); 320100 (Mouse); 101865743 (Cynomolgus Monkey)
Alternate Names
Receptor expressed in lymphoid tissues; RELT tumor necrosis factor receptor; RELT; TNFRSF19L; TNFRSF19LFLJ14993; tumor necrosis factor receptor superfamily member 19L; tumor necrosis factor receptor superfamily, member 19-like


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