Recombinant Mouse IFN-gamma Protein, CF

(178 citations)   
  • Purity
    >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Endotoxin Level
    <0.10 EU per 1 μg of the protein by the LAL method.
  • Activity
    Measured in an anti-viral assay using L‑929 mouse fibroblast cells infected with encephalomyocarditis (EMC) virus. Vogel, S.N. et al. (1982) Infect. Immunol. 38:681. The ED50 for this effect is 0.3-0.9 ng/mL.
  • Source
    E. coli-derived His23-Cys155, with an N-terminal Met
  • Accession #
  • N-terminal Sequence
    Analysis
    Met
  • Predicted Molecular Mass
    15.6 kDa
  • SDS-PAGE
    11-12 kDa, reducing conditions
Carrier Free
What does CF mean?
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
What formulation is right for me?
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
485-MI/CF
 
485-MI
Formulation Lyophilized from a 0.2 μm filtered solution in Sodium Succinate, Mannitol,Tween® 80 and TCEP with Trehalose.
Formulation Lyophilized from a 0.2 μm filtered solution in Sodium Succinate, Mannitol,Tween® 80 and TCEP with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Data Images
Recombinant Mouse IFN-gamma (Catalog # 485‑ML/CF) demonstrates anti-viral activity in L‑929 mouse fibroblast cells infected with encephalomyocarditis (EMC) virus. The ED50 for this effect is 0.3-0.9 ng/mL.
1 μg/lane of Recombinant Mouse IFN-gamma was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 11-12 kDa.
Background: IFN-gamma
Interferon-gamma (IFN-gamma ), also known as type II or immune interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine (1, 2). Mature mouse IFN-gamma exists as a noncovalently linked homodimer of 20-25 kDa variably glycosylated subunits (3). It shares 86% amino acid sequence identity with rat IFN-gamma and 38%-44% with bovine, canine, cotton rat, equine, feline, human, porcine, and rhesus IFN-gamma. IFN-gamma dimers bind to IFN‑ gamma RI (alpha subunits) which then interact with IFN-gamma RII (beta subunits) to form the functional receptor complex of two alpha and two beta subunits. Inclusion of IFN-gamma RII increases the binding affinity for ligand and the efficiency of signal transduction (4, 5). IFN-gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells (6). It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up-regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects (6, 7). In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation (8, 9). The pleiotropic effects of IFN-gamma contribute to the development of multiple aspects of atherosclerosis (7).
  • References:
    1. Billiau, A. and P. Matthys (2009) Cytokine Growth Factor Rev. 20:97.
    2. Pestka, S. et al. (2004) Immunol. Rev. 202:8.
    3. Gray, P.W. and D.V. Goeddel (1983) Proc. Natl. Acad. Sci. 80:5842.
    4. Marsters, S.A. et al. (1995) Proc. Natl. Acad. Sci. 92:5401.
    5. Krause, C.D. et al. (2000) J. Biol. Chem. 275:22995.
    6. Schroder, K. et al. (2004) J. Leukoc. Biol. 75:163.
    7. McLaren, J.E. and D.P. Ramji (2009) Cytokine Growth Factor Rev. 20:125.
    8. Muhl, H. and J. Pfeilschifter (2003) Int. Immunopharmacol. 3:1247.
    9. Kelchtermans, H. et al. (2008) Trends Immunol. 29:479.
  • Long Name:
    Interferon gamma
  • Entrez Gene IDs:
    3458 (Human); 15978 (Mouse); 25712 (Rat); 396991 (Porcine); 281237 (Bovine); 403801 (Canine); 493965 (Feline)
  • Alternate Names:
    IFG; IFI; IFNG; IFNgamma; IFN-gamma; Immune interferon; interferon gamma; interferon, gamma
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

178 Citations: Showing 1 - 10
Filter your results:

Species
Applications
Sample Type
  1. Nitric Oxide Modulates Macrophage Responses to Mycobacterium tuberculosis Infection through Activation of HIF-1? and Repression of NF-?B
    Authors: J Braverman, SA Stanley
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  2. IL-10 down-regulates the expression of survival associated gene hspX of Mycobacterium tuberculosis in murine macrophage
    Authors: B Jee, P Sharma, K Katoch, B Joshi, SK Awasthi
    Braz J Infect Dis, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  3. Pathogen-mediated manipulation of arthropod microbiota to promote infection
    Authors: NM Abraham, L Liu, BL Jutras, AK Yadav, S Narasimhan, V Gopalakris, JM Ansari, KK Jefferson, F Cava, C Jacobs-Wag, E Fikrig
    Proc. Natl. Acad. Sci. U.S.A, 2017;114(5):E781-E790.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  4. Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis
    Authors: MA L‚cuyer, O Saint-Laur, L BourbonniŠ, S Larouche, C Larochelle, L Michel, M Charabati, M Abadier, S Zandee, N Haghayegh, E Gowing, C Pittet, R Lyck, B Engelhardt, A Prat
    Proc. Natl. Acad. Sci. U.S.A, 2017;114(4):E524-E533.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  5. Metabolic origins of spatial organization in the tumor microenvironment
    Authors: C Carmona-Fo, M Deforet, L Akkari, CB Thompson, JA Joyce, JB Xavier
    Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  6. Gut memories do not fade: epigenetic regulation of lasting gut homing receptor expression in CD4(+) memory T cells
    Authors: BA Szilagyi, J Triebus, C Kressler, M de Almeida, S Tierling, P Durek, M Mardahl, A Szilagyi, S Floess, J Huehn, U Syrbe, J Walter, JK Polansky, A Hamann
    Mucosal Immunol, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  7. Astrocytic orosomucoid-2 modulates microglial activation and neuroinflammation
    Authors: M Jo, JH Kim, G Song, M Seo, E Mi Hwang, K Suk
    J. Neurosci, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  8. Robust growth of avirulent phase II Coxiella burnetii in bone marrow-derived murine macrophages
    Authors: DC Cockrell, CM Long, SJ Robertson, JG Shannon, HE Miller, L Myers, CL Larson, T Starr, PA Beare, RA Heinzen
    PLoS ONE, 2017;12(3):e0173528.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  9. PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy
    Authors: S Gao, C Li, Y Zhu, Y Wang, A Sui, Y Zhong, B Xie, X Shen
    Sci Rep, 2017;7(0):42846.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  10. Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk
    Authors: V Piccolo, A Curina, M Genua, S Ghisletti, M Simonatto, A Sabò, B Amati, R Ostuni, G Natoli
    Nat. Immunol, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  11. The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression
    Authors: R Ahn, V Sabourin, AM Bolt, S Hébert, S Totten, N De Jay, MC Festa, YK Young, YK Im, T Pawson, AE Koromilas, WJ Muller, KK Mann, CL Kleinman, J Ursini-Sie
    Nat Commun, 2017;8(0):14638.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  12. MicroRNA-27a promotes podocyte injury via PPAR?-mediated ?-catenin activation in diabetic nephropathy
    Authors: Z Zhou, J Wan, X Hou, J Geng, X Li, X Bai
    Cell Death Dis, 2017;8(3):e2658.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  13. STAT3 promotes IFN?/TNF?-induced muscle wasting in an NF-?B-dependent and IL-6-independent manner
    Authors: JF Ma, BJ Sanchez, DT Hall, AK Tremblay, S Di Marco, IE Gallouzi
    EMBO Mol Med, 2017;0(0):.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  14. Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice
    Authors: J Lau, J Cheung, A Navarro, S Lianoglou, B Haley, K Totpal, L Sanders, H Koeppen, P Caplazi, J McBride, H Chiu, R Hong, J Grogan, V Javinal, R Yauch, B Irving, M Belvin, I Mellman, JM Kim, M Schmidt
    Nat Commun, 2017;8(0):14572.
    Species: Mouse
    Sample Type: Cell Culture Supernates
    Application: Bioassay
  15. A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages
    Authors: AJ Morales, JA Carrero, PJ Hung, AT Tubbs, JM Andrews, BT Edelson, B Calderon, CL Innes, RS Paules, JE Payton, BP Sleckman
    Elife, 2017;6(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  16. Microglia activation is essential for BMP7-mediated retinal reactive gliosis
    Authors: S Dharmaraja, DL Fisk, CM Sorenson, N Sheibani, TL Belecky-Ad
    J Neuroinflammation, 2017;14(1):76.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  17. IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population
    Authors: DC Nascimento, PH Melo, AR Piñeros, RG Ferreira, DF Colón, PB Donate, FV Castanheir, A Gozzi, PG Czaikoski, W Niedbala, MC Borges, DS Zamboni, FY Liew, FQ Cunha, JC Alves-Filh
    Nat Commun, 2017;8(0):14919.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  18. Modulation of Roquin Function in Myeloid Cells Reduces Mycobacterium tuberculosis-Induced Inflammation
    Authors: G Nagalingam, CG Vinuesa, WJ Britton, BM Saunders
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  19. Prolactin blocks the expression of receptor activator of nuclear factor ?B ligand and reduces osteoclastogenesis and bone loss in murine inflammatory arthritis
    Authors: MG Ledesma-Co, N Adán, G Ortiz, M Solís-Guti, F López-Barr, G Martínez d, C Clapp
    Arthritis Res. Ther., 2017;19(1):93.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  20. KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients
    Authors: L Quinti, S Dayalan Na, U Träger, X Chen, K Kegel-Glea, D Llères, C Connolly, V Chopra, C Low, S Moniot, E Sapp, AR Tousley, P Vodicka, MJ Van Kanega, LS Kaltenbach, LA Crawford, M Fuszard, M Higgins, JRC Miller, RE Farmer, V Potluri, S Samajdar, L Meisel, N Zhang, A Snyder, R Stein, SM Hersch, LM Ellerby, E Weerapana, MA Schwarzsch, C Steegborn, BR Leavitt, A Degterev, SJ Tabrizi, DC Lo, M DiFiglia, LM Thompson, AT Dinkova-Ko, AG Kazantsev
    Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  21. CD4(+)CD8?(+) double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin
    Authors: NH Overgaard, JL Cruz, JA Bridge, HJ Nel, IH Frazer, NL La Gruta, A Blumenthal, RJ Steptoe, JW Wells
    J. Leukoc. Biol., 2017;0(0):.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  22. Interferon-? derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity
    Authors: P Bhat, G Leggatt, N Waterhouse, IH Frazer
    Cell Death Dis, 2017;8(6):e2836.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  23. Conditionally Immortal Slc4a11-/- Mouse Corneal Endothelial Cell Line Recapitulates Disrupted Glutaminolysis Seen in Slc4a11-/- Mouse Model
    Authors: W Zhang, DG Ogando, ET Kim, MJ Choi, H Li, JM Tenessen, JA Bonanno
    Invest. Ophthalmol. Vis. Sci., 2017;58(9):3723-3731.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  24. Pancreatic ?-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF)
    Authors: DA Cunha, M Cito, FA Grieco, C Cosentino, T Danilova, L Ladriere, M Lindahl, A Domanskyi, M Bugliani, P Marchetti, DL Eizirik, M Cnop
    J. Biol. Chem., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  25. TRIM21 is critical for survival of Toxoplasma gondii infection and localises to GBP-positive parasite vacuoles
    Authors: C Foltz, A Napolitano, R Khan, B Clough, EM Hirst, EM Frickel
    Sci Rep, 2017;7(1):5209.
  26. The PSMP-CCR2 interactions trigger monocyte/macrophage-dependent colitis
    Authors: X Pei, D Zheng, S She, J Ma, C Guo, X Mo, Y Zhang, Q Song, Y Zhang, D Ma, Y Wang
    Sci Rep, 2017;7(1):5107.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  27. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
    Nat Commun, 2016;7(0):11624.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  28. Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis
    Authors: C Shimojima, H Takeuchi, S Jin, B Parajuli, H Hattori, A Suzumura, H Hibi, M Ueda, A Yamamoto
    J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  29. Type I interferons exert anti-tumor effect via reversing immunosuppression mediated by mesenchymal stromal cells
    Authors: P Shou, Q Chen, J Jiang, C Xu, J Zhang, C Zheng, M Jiang, T Velletri, W Cao, Y Huang, Q Yang, X Han, L Zhang, L Wei, AB Rabson, YE Chin, Y Wang, Y Shi
    Oncogene, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  30. Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei
    PLoS Negl Trop Dis, 2016;10(8):e0004907.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  31. HIF-1? Is an Essential Mediator of IFN-?-Dependent Immunity to Mycobacterium tuberculosis
    J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  32. Mycobacterium leprae-induced Insulin-like Growth Factor I attenuates antimicrobial mechanisms, promoting bacterial survival in macrophages
    Authors: L R Batista-Si
    Sci Rep, 2016;6(0):27632.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  33. Platelets Guide Leukocytes to Their Sites of Extravasation
    PLoS Biol, 2016;14(5):e1002459.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  34. Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor
    Nat Med, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  35. NADPH oxidases are essential for macrophage differentiation
    J Biol Chem, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  36. Elastin-Derived Peptides Promote Abdominal Aortic Aneurysm Formation by Modulating M1/M2 Macrophage Polarization
    J Immunol, 2016;196(11):4536-43.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  37. Lack of immunoediting in murine pancreatic cancer reversed with neoantigen
    JCI Insight, 2016;1(14):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  38. G2A Signaling Dampens Colitic Inflammation via Production of IFN-?
    J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  39. Tumor-intrinsic PD-L1 signals regulate cell growth, pathogenesis and autophagy in ovarian cancer and melanoma
    Cancer Res, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  40. Polarization of macrophages towards M2 phenotype is favored by reduction in iPLA2?
    J Biol Chem, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  41. Macrophages form functional vascular mimicry channels in vivo
    Sci Rep, 2016;6(0):36659.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  42. Identification and Function of Fibrocytes in Skeletal Muscle Injury Repair and Muscular Dystrophy
    J. Immunol., 2016;197(12):4750-4761.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  43. Mechanisms Underlying Interferon-?-Induced Priming of Microglial Reactive Oxygen Species Production
    PLoS ONE, 2016;11(9):e0162497.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  44. Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis
    Sci Rep, 2016;6(0):37977.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  45. Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation
    Sci Rep, 2016;6(0):38387.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  46. Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses
    Authors: LN Guthrie, K Abiraman, ES Plyler, NT Sprenkle, SA Gibson, BC McFarland, R Rajbhandar, AL Rowse, EN Benveniste, GP Meares
    J. Biol. Chem., 2016;291(30):15830-40.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  47. Anti-Tumor and Immune Enhancing Activities of Rice Bran Gramisterol on Acute Myelogenous Leukemia.
    Authors: Somintara S, Leardkamolkarn V, Suttiarporn P, Mahatheeranont S
    PLoS ONE, 2016;11(1):e0146869.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  48. Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9.
    Authors: Doench J, Fusi N, Sullender M, Hegde M, Vaimberg E, Donovan K, Smith I, Tothova Z, Wilen C, Orchard R, Virgin H, Listgarten J, Root D
    Nat Biotechnol, 2016;34(2):184-91.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  49. Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status
    Circ Res, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  50. TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms.
    Authors: Hu M, Xie X, Yang Q, Liao C, Ye W, Lin H, Shu H
    J Immunol, 2015;195(9):4415-25.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  51. Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization.
    Authors: Liu K, Zhao E, Ilyas G, Lalazar G, Lin Y, Haseeb M, Tanaka K, Czaja M
    Autophagy, 2015;11(2):271-84.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  52. IFN-gamma Prevents Adenosine Receptor (A2bR) Upregulation To Sustain the Macrophage Activation Response.
    Authors: Cohen H, Ward A, Hamidzadeh K, Ravid K, Mosser D
    J Immunol, 2015;195(8):3828-37.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  53. Effector T Cell Egress via Afferent Lymph Modulates Local Tissue Inflammation.
    Authors: Gomez D, Diehl M, Crosby E, Weinkopff T, Debes G
    J Immunol, 2015;195(8):3531-6.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  54. Activated Brain Endothelial Cells Cross-Present Malaria Antigen.
    Authors: Howland S, Poh C, Renia L
    PLoS Pathog, 2015;11(6):e1004963.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  55. Protective role for caspase-11 during acute experimental murine colitis.
    Authors: Oficjalska K, Raverdeau M, Aviello G, Wade S, Hickey A, Sheehan K, Corr S, Kay E, O'Neill L, Mills K, Creagh E
    J Immunol, 2015;194(3):1252-60.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  56. Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate.
    Authors: Zhao Y, Scott N, Quah H, Krishnamurthy B, Bond F, Loudovaris T, Mannering S, Kay T, Thomas H
    Eur J Immunol, 2015;45(9):2494-503.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  57. Glycogen Synthase Kinase-3beta (GSK-3beta) Inhibition Enhances Dendritic Cell-based Cancer Vaccine Potency via Suppression of Interferon-gamma-induced Indoleamine 2,3-Dioxygenase Expression.
    Authors: Noh K, Son K, Jung I, Kang T, Choi C, Park Y
    J Biol Chem, 2015;290(19):12394-402.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  58. Dynamics of Circulating gammadelta T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma.
    Authors: Beck B, Kim H, O'Brien R, Jadus M, Gillespie G, Cloud G, Hoa N, Langford C, Lopez R, Harkins L, Lamb L
    PLoS ONE, 2015;10(5):e0122387.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  59. Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.
    Authors: Haines J, Herbin O, de la Hera B, Vidaurre O, Moy G, Sun Q, Fung H, Albrecht S, Alexandropoulos K, McCauley D, Chook Y, Kuhlmann T, Kidd G, Shacham S, Casaccia P
    Nat Neurosci, 2015;18(4):511-20.
    Species: Mouse
    Sample Type: In Vivo
  60. A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages.
    Authors: Mancino A, Termanini A, Barozzi I, Ghisletti S, Ostuni R, Prosperini E, Ozato K, Natoli G
    Genes Dev, 2015;29(4):394-408.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  61. The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity.
    Authors: Sag D, Cekic C, Wu R, Linden J, Hedrick C
    Nat Commun, 2015;6(0):6354.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  62. Interferon Gamma, but not Calcitriol Improves the Osteopetrotic Phenotypes in ADO2 Mice.
    Authors: Alam I, Gray A, Acton D, Gerard-O'Riley R, Reilly A, Econs M
    J Bone Miner Res, 2015;30(11):2005-13.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  63. Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice.
    Authors: Goodsmith N, Guo X, Vandal O, Vaubourgeix J, Wang R, Botella H, Song S, Bhatt K, Liba A, Salgame P, Schnappinger D, Ehrt S
    PLoS Pathog, 2015;11(2):e1004645.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  64. Distinct functions of epidermal and myeloid-derived VEGF-A in skin tumorigenesis mediated by HPV8.
    Authors: Ding X, Lucas T, Marcuzzi G, Pfister H, Eming S
    Cancer Res, 2015;75(2):330-43.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  65. Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus.
    Authors: Herbst S, Shah A, Mazon Moya M, Marzola V, Jensen B, Reed A, Birrell M, Saijo S, Mostowy S, Shaunak S, Armstrong-James D
    EMBO Mol Med, 2015;7(3):240-58.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  66. Defining immunological impact and therapeutic benefit of mild heating in a murine model of arthritis.
    Authors: Lee C, Kokolus K, Leigh N, Capitano M, Hylander B, Repasky E
    PLoS ONE, 2015;10(3):e0120327.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  67. Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells.
    Authors: Guay C, Menoud V, Rome S, Regazzi R
    Cell Commun Signal, 2015;13(0):17.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  68. Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS.
    Authors: Ma F, Li B, Liu S, Iyer S, Yu Y, Wu A, Cheng G
    J Immunol, 2015;194(4):1545-54.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  69. Epidermal Expression and Regulation of Interleukin-33 during Homeostasis and Inflammation: Strong Species Differences.
    Authors: Sundnes O, Pietka W, Loos T, Sponheim J, Rankin A, Pflanz S, Bertelsen V, Sitek J, Hol J, Haraldsen G, Khnykin D
    J Invest Dermatol, 2015;135(7):1771-80.
  70. Synergistic up-regulation of CXCL10 by virus and IFN gamma in human airway epithelial cells.
    Authors: Oslund K, Zhou X, Lee B, Zhu L, Duong T, Shih R, Baumgarth N, Hung L, Wu R, Chen Y
    PLoS ONE, 2014;9(7):e100978.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  71. Site-specific chemokine expression regulates central nervous system inflammation and determines clinical phenotype in autoimmune encephalomyelitis.
    Authors: Stoolman J, Duncker P, Huber A, Segal B
    J Immunol, 2014;193(2):564-70.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  72. Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis.
    Authors: Steelman A, Smith R, Welsh C, Li J
    J Biol Chem, 2014;288(33):23776-87.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  73. TGF-beta promotes immune responses in the presence of mesenchymal stem cells.
    Authors: Xu C, Yu P, Han X, DU L, Gan J, Wang Y, Shi Y
    J Immunol, 2014;192(1):103-9.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  74. Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-gamma.
    Authors: Farin H, Karthaus W, Kujala P, Rakhshandehroo M, Schwank G, Vries R, Kalkhoven E, Nieuwenhuis E, Clevers H
    J Exp Med, 2014;211(7):1393-405.
    Species: Mouse
    Sample Type: Whole Tissue
    Application: Bioassay
  75. NRROS negatively regulates reactive oxygen species during host defence and autoimmunity.
    Authors: Noubade, Rajkumar, Wong, Kit, Ota, Naruhisa, Rutz, Sascha, Eidenschenk, Celine, Valdez, Patricia, Ding, Jiabing, Peng, Ivan, Sebrell, Andrew, Caplazi, Patrick, DeVoss, Jason, Soriano, Robert H, Sai, Tao, Lu, Rongze, Modrusan, Zora, Hackney, Jason, Ouyang, Wenjun
    Nature, 2014;509(7499):235-9.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  76. Intramolecular polyspecificity in CD4 T-cell recognition of Ad-restricted epitopes of proteoglycan aggrecan.
    Authors: Falconer J, Lowes K, Furmanski A, Dyson J, Ng W, Robinson J
    Immunology, 2014;142(1):101-110.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  77. Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4.
    Authors: Yu C, Nguyen T, Irvine K, Sweet M, Frazer I, Blumenthal A
    Eur J Immunol, 2014;44(5):1480-90.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  78. A novel immunomodulatory function of PHLPP1: inhibition of iNOS via attenuation of STAT1 ser727 phosphorylation in mouse macrophages.
    Authors: Alamuru N, Behera S, Butchar J, Tridandapani S, Kaimal Suraj S, Babu P, Hasnain S, Ehtesham N, Parsa K
    J Leukoc Biol, 2014;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  79. All-trans retinoic acid induces arginase-1 and inducible nitric oxide synthase-producing dendritic cells with T cell inhibitory function.
    Authors: Bhatt S, Qin J, Bennett C, Qian S, Fung J, Hamilton T, Lu L
    J Immunol, 2014;192(11):5098-108.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  80. PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis.
    Authors: Yang L, Xie M, Yang M, Yu Y, Zhu S, Hou W, Kang R, Lotze M, Billiar T, Wang H, Cao L, Tang D
    Nat Commun, 2014;5(0):4436.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  81. Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis.
    Authors: Liu Y, Holdbrooks A, De Sarno P, Rowse A, Yanagisawa L, McFarland B, Harrington L, Raman C, Sabbaj S, Benveniste E, Qin H
    J Immunol, 2014;192(1):59-72.
  82. Reversal of beta cell de-differentiation by a small molecule inhibitor of the TGFbeta pathway.
    Authors: Blum B, Roose A, Barrandon O, Maehr R, Arvanites A, Davidow L, Davis J, Peterson Q, Rubin L, Melton D
    Elife, 2014;3(0):e02809.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  83. Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis.
    Authors: Moon C, VanDussen K, Miyoshi H, Stappenbeck T
    Mucosal Immunol, 2014;7(4):818-28.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  84. Collective nitric oxide production provides tissue-wide immunity during Leishmania infection.
    Authors: Olekhnovitch R, Ryffel B, Muller A, Bousso P
    J Clin Invest, 2014;124(4):1711-22.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  85. Endothelial cell-derived chemerin promotes dendritic cell transmigration.
    Authors: Gonzalvo-Feo S, Del Prete A, Pruenster M, Salvi V, Wang L, Sironi M, Bierschenk S, Sperandio M, Vecchi A, Sozzani S
    J Immunol, 2014;192(5):2366-73.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  86. Delineating the importance of serum opsonins and the bacterial capsule in affecting the uptake and killing of Burkholderia pseudomallei by murine neutrophils and macrophages.
    Authors: Mulye M, Bechill M, Grose W, Ferreira V, Lafontaine E, Wooten R
    PLoS Negl Trop Dis, 2014;8(8):e2988.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  87. MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration.
    Authors: Cebrian C, Zucca F, Mauri P, Steinbeck J, Studer L, Scherzer C, Kanter E, Budhu S, Mandelbaum J, Vonsattel J, Zecca L, Loike J, Sulzer D
    Nat Commun, 2014;5(0):3633.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  88. IFN-gamma primes macrophage activation by increasing phosphatase and tensin homolog via downregulation of miR-3473b.
    Authors: Wu C, Xue Y, Wang P, Lin L, Liu Q, Li N, Xu J, Cao X
    J Immunol, 2014;193(6):3036-44.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  89. USP18 is crucial for IFN-gamma-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity.
    Authors: Hong B, Li H, Lu Y, Zhang M, Zheng Y, Qian J, Yi Q
    Mol Cancer, 2014;13(0):132.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  90. Curcumin ameliorates autoimmune diabetes. Evidence in accelerated murine models of type 1 diabetes.
    Authors: Castro C, Barcala Tabarrozzi A, Winnewisser J, Gimeno M, Antunica Noguerol M, Liberman A, Paz D, Dewey R, Perone M
    Clin Exp Immunol, 2014;177(1):149-60.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  91. Control of intracellular Francisella tularensis by different cell types and the role of nitric oxide.
    Authors: Newstead S, Gates A, Hartley M, Rowland C, Williamson E, Lukaszewski R
    J Immunol Res, 2014;2014(0):694717.
  92. IL-13 orchestrates resolution of chronic intestinal inflammation via phosphorylation of glycogen synthase kinase-3beta.
    Authors: Fichtner-Feigl S, Kesselring R, Martin M, Obermeier F, Ruemmele P, Kitani A, Brunner S, Haimerl M, Geissler E, Strober W, Schlitt H
    J Immunol, 2014;192(8):3969-80.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  93. Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment.
    Authors: Ling W, Zhang J, Yuan Z, Ren G, Zhang L, Chen X, Rabson A, Roberts A, Wang Y, Shi Y
    Cancer Res, 2014;74(5):1576-87.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  94. Peroxisome proliferator-activated receptor alpha protects capillary pericytes in the retina.
    Authors: Ding L, Cheng R, Hu Y, Takahashi Y, Jenkins A, Keech A, Humphries K, Gu X, Elliott M, Xia X, Ma J
    Am J Pathol, 2014;184(10):2709-20.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  95. Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma.
    Authors: Shibata T, Habiel D, Coelho A, Kunkel S, Lukacs N, Hogaboam C
    J Immunol, 2014;192(8):3569-81.
    Species: Mouse
    Sample Type: Tissue Homogenates
    Application: Luminex standard
  96. Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells.
    Authors: Ikeda T, Hirata S, Takamatsu K, Haruta M, Tsukamoto H, Ito T, Uchino M, Ando Y, Nagafuchi S, Nishimura Y, Senju S
    PLoS ONE, 2014;9(12):e115198.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  97. Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.
    Authors: Dohi, Kenji, Kraemer, Brian C, Erickson, Michelle, McMillan, Pamela J, Kovac, Andrej, Flachbartova, Zuzana, Hansen, Kim M, Shah, Gul N, Sheibani, Nader, Salameh, Therese, Banks, William
    PLoS ONE, 2014;9(9):e108034.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  98. NK cells are required for dendritic cell-based immunotherapy at the time of tumor challenge.
    Authors: Bouwer A, Saunderson S, Caldwell F, Damani T, Pelham S, Dunn A, Jack R, Stoitzner P, McLellan A
    J Immunol, 2014;192(5):2514-21.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  99. Essential role of CD11a in CD8+ T-cell accumulation and activation in adipose tissue.
    Authors: Jiang E, Perrard X, Yang D, Khan I, Perrard J, Smith C, Ballantyne C, Wu H
    Arterioscler Thromb Vasc Biol, 2014;34(1):34-43.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  100. Interferon regulatory factor 1 restricts gammaherpesvirus replication in primary immune cells.
    Authors: Mboko W, Mounce B, Emmer J, Darrah E, Patel S, Tarakanova V
    J Virol, 2014;88(12):6993-7004.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  101. The primary cilium influences interleukin-1beta-induced NFkappaB signalling by regulating IKK activity.
    Authors: Wann A, Chapple J, Knight M
    Cell Signal, 2014;26(8):1735-42.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  102. Preferential macrophage recruitment and polarization in LPS-induced animal model for COPD: noninvasive tracking using MRI.
    Authors: Al Faraj, Achraf, Sultana Shaik, Asma, Pureza, Mary Ang, Alnafea, Mohammad, Halwani, Rabih
    PLoS ONE, 2014;9(3):e90829.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  103. Comparison of osteogenic differentiation of embryonic stem cells and primary osteoblasts revealed by responses to IL-1beta, TNF-alpha, and IFN-gamma.
    Authors: Sidney L, Kirkham G, Buttery L
    Stem Cells Dev, 2014;23(6):605-17.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  104. Steady-state antigen scavenging, cross-presentation, and CD8+ T cell priming: a new role for lymphatic endothelial cells.
    Authors: Hirosue S, Vokali E, Raghavan V, Rincon-Restrepo M, Lund A, Corthesy-Henrioud P, Capotosti F, Halin Winter C, Hugues S, Swartz M
    J Immunol, 2014;192(11):5002-11.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  105. TGFbeta-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.
    Authors: Suresh Babu S, Valdez Y, Xu A, O'Byrne A, Calvo F, Lei V, Conway E
    BMC Cancer, 2014;14(0):113.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  106. Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization.
    Authors: Tatano Y, Shimizu T, Tomioka H
    Sci Rep, 2014;4(0):4146.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  107. Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase.
    Authors: Sriskantharajah S, Guckel E, Tsakiri N, Kierdorf K, Brender C, Ben-Addi A, Veldhoen M, Tsichlis P, Stockinger B, O'Garra A, Prinz M, Kollias G, Ley S
    J Immunol, 2014;192(8):3518-29.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  108. Improved repair of dermal wounds in mice lacking microRNA-155.
    Authors: van Solingen C, Araldi E, Chamorro-Jorganes A, Fernandez-Hernando C, Suarez Y
    J Cell Mol Med, 2014;18(6):1104-12.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  109. Everolimus limits aortic aneurysm in the apolipoprotein E-deficient mouse by downregulating C-C chemokine receptor 2 positive monocytes.
    Authors: Moran C, Jose R, Moxon J, Roomberg A, Norman P, Rush C, Korner H, Golledge J
    Arterioscler Thromb Vasc Biol, 2013;33(4):814-21.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  110. Association of beta-catenin with P-Smad3 but not LEF-1 dissociates in vitro profibrotic from anti-inflammatory effects of TGF-beta1.
    Authors: Tian X, Zhang J, Tan T, Lyons J, Zhao H, Niu B, Lee S, Tsatralis T, Zhao Y, Wang Y, Cao Q, Wang C, Wang Y, Lee V, Kahn M, Zheng G, Harris D
    J Cell Sci, 2013;126(0):67-76.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  111. Cannabinoid 1 receptors in keratinocytes modulate proinflammatory chemokine secretion and attenuate contact allergic inflammation.
    Authors: Gaffal E, Cron M, Glodde N, Bald T, Kuner R, Zimmer A, Lutz B, Tuting T
    J Immunol, 2013;190(10):4929-36.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  112. Regulation and migratory role of P-selectin ligands during intestinal inflammation.
    Authors: Hoffmann U, Pink M, Lauer U, Heimesaat M, Winsauer C, Kruglov A, Schlawe K, Leichsenring C, Liesenfeld O, Hamann A, Syrbe U
    PLoS ONE, 2013;8(4):e62055.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  113. Differentially imprinted innate immunity by mucosal boost vaccination determines antituberculosis immune protective outcomes, independent of T-cell immunity.
    Authors: Jeyanathan M, Damjanovic D, Shaler C, Lai R, Wortzman M, Yin C, Zganiacz A, Lichty B, Xing Z
    Mucosal Immunol, 2013;6(3):612-25.
  114. Decorin potentiates interferon-gamma activity in a model of allergic inflammation.
    Authors: Bocian C, Urbanowitz A, Owens R, Iozzo R, Gotte M, Seidler D
    J Biol Chem, 2013;288(18):12699-711.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  115. IL-9-producing invariant NKT cells protect against DSS-induced colitis in an IL-4-dependent manner.
    Authors: Kim H, Chung D
    Mucosal Immunol, 2013;6(2):347-57.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  116. IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic inflammation.
    Authors: Veremeyko, Tatyana, Siddiqui, Shafiudd, Sotnikov, Ilya, Yung, Amanda, Ponomarev, Eugene D
    PLoS ONE, 2013;8(12):e81774.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  117. Endoglin regulates the activation and quiescence of endothelium by participating in canonical and non-canonical TGF-beta signaling pathways.
    Authors: Park S, Dimaio T, Liu W, Wang S, Sorenson C, Sheibani N
    J Cell Sci, 2013;126(0):1392-405.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  118. Anti-CD70 immunocytokines for exploitation of interferon-gamma-induced RIP1-dependent necrosis in renal cell carcinoma.
    Authors: Chen P, Nogusa S, Thapa R, Shaller C, Simmons H, Peri S, Adams G, Balachandran S
    PLoS ONE, 2013;8(4):e61446.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  119. The exonuclease Trex1 restrains macrophage proinflammatory activation.
    Authors: Pereira-Lopes S, Celhar T, Sans-Fons G, Serra M, Fairhurst A, Lloberas J, Celada A
    J Immunol, 2013;191(12):6128-35.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  120. Calmodulin-dependent protein kinase II/cAMP response element-binding protein/Wnt/beta-catenin signaling cascade regulates angiotensin II-induced podocyte injury and albuminuria.
    Authors: Jiang L, Xu L, Song Y, Li J, Mao J, Zhao A, He W, Yang J, Dai C
    J Biol Chem, 2013;288(32):23368-79.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  121. Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii.
    Authors: Selleck E, Fentress S, Beatty W, Degrandi D, Pfeffer K, Virgin H, Macmicking J, Sibley L
    PLoS Pathog, 2013;9(4):e1003320.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  122. An antioxidant role for catecholate siderophores in Salmonella.
    Authors: Achard, Maud E S, Chen, Kaiwen W, Sweet, Matthew, Watts, Rebecca, Schroder, Kate, Schembri, Mark A, McEwan, Alastair
    Biochem J, 2013;454(3):543-9.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  123. CD43-mediated IFN-gamma production by CD8+ T cells promotes abdominal aortic aneurysm in mice.
    Authors: Zhou H, Yan H, Cannon J, Springer L, Green J, Pham C
    J Immunol, 2013;190(10):5078-85.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  124. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012;109(25):9971-6.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  125. ATP release and autocrine signaling through P2X4 receptors regulate gammadelta T cell activation.
    Authors: Manohar M, Hirsh M, Chen Y, Woehrle T, Karande A, Junger W
    J Leukoc Biol, 2012;92(4):787-94.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  126. Interferon gamma inhibits adipogenesis in vitro and prevents marrow fat infiltration in oophorectomized mice.
    Authors: Vidal C, Bermeo S, Li W, Huang D, Kremer R, Duque G
    Stem Cells, 2012;30(5):1042-8.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  127. IL-6 mediates the susceptibility of glycoprotein 130 hypermorphs to Toxoplasma gondii.
    J. Immunol., 2012;187(1):350-60.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  128. Host-derived MCP-1 and MIP-1alpha regulate protective anti-tumor immunity to localized and metastatic B16 melanoma.
    Authors: Nakasone Y, Fujimoto M, Matsushita T, Hamaguchi Y, Huu DL, Yanaba M, Sato S, Takehara K, Hasegawa M
    Am. J. Pathol., 2012;180(1):365-74.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  129. Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue.
    Authors: Nicholls HT, Kowalski G, Kennedy DJ
    Diabetes, 2011;60(4):1100-10.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  130. The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss.
    Authors: Liang S, Krauss JL, Domon H, McIntosh ML, Hosur KB, Qu H, Li F, Tzekou A, Lambris JD, Hajishengallis G
    J. Immunol., 2011;186(2):869-77.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  131. Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15R alpha.
    Authors: Sato N, Sabzevari H, Fu S, Ju W, Petrus MN, Bamford RN, Waldmann TA, Tagaya Y
    Blood, 2011;117(15):4032-40.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  132. A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa.
    Authors: Kotarsky K, Sitnik KM, Stenstad H, Kotarsky H, Schmidtchen A, Koslowski M, Wehkamp J, Agace WW
    Mucosal Immunol, 2010;3(1):40-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  133. IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation.
    Authors: Zaki MH, Vogel P, Body-Malapel M, Lamkanfi M, Kanneganti TD
    J. Immunol., 2010;185(8):4912-20.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  134. Commensal microflora and interferon-gamma promote steady-state interleukin-7 production in vivo.
    Authors: Shalapour S, Deiser K, Sercan O, Tuckermann J, Minnich K, Willimsky G, Blankenstein T, Hammerling GJ, Arnold B, Schuler T
    Eur. J. Immunol., 2010;40(9):2391-400.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  135. Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages.
    Authors: Filardy AA, Pires DR, Nunes MP, Takiya CM, Freire-de-Lima CG, Ribeiro-Gomes FL, DosReis GA
    J. Immunol., 2010;185(4):2044-50.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Cell Preparation
  136. Phosphatidylinositol 3-kinase/protein kinase Cdelta activation induces close homolog of adhesion molecule L1 (CHL1) expression in cultured astrocytes.
    Authors: Wu J, Wrathall JR, Schachner M
    Glia, 2010;58(3):315-28.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  137. IL-1RL2 and its ligands contribute to the cytokine network in psoriasis.
    Authors: Blumberg H, Dinh H, Dean C, Trueblood ES, Bailey K, Shows D, Bhagavathula N, Aslam MN, Varani J, Towne JE, Sims JE
    J. Immunol., 2010;185(7):4354-62.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  138. Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production.
    Authors: Lemos HP, Grespan R, Vieira SM, Cunha TM, Verri WA, Fernandes KS, Souto FO, McInnes IB, Ferreira SH, Liew FY, Cunha FQ
    Proc. Natl. Acad. Sci. U.S.A., 2009;106(14):5954-9.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  139. Vaccination route that induces transforming growth factor beta production fails to elicit protective immunity against Leishmania donovani infection.
    Authors: Bhowmick S, Mazumdar T, Ali N
    Infect. Immun., 2009;77(4):1514-23.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  140. The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells.
    Authors: Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D, Noubade R, Briso EM, Charland C, Leonard WJ, Ciliberto G, Teuscher C, Haynes L, Rincon M
    J. Exp. Med., 2009;206(1):69-78.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  141. Thymic regulation of autoimmune disease by accelerated differentiation of Foxp3+ regulatory T cells through IL-7 signaling pathway.
    Authors: Chen X, Fang L, Song S, Guo TB, Liu A, Zhang JZ
    J. Immunol., 2009;183(10):6135-44.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  142. ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis.
    Authors: Wieland CW, van der Windt GJ, Florquin S, McKenzie AN, van der Poll T
    Microbes Infect., 2009;11(4):524-30.
  143. T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes.
    Authors: Guarda G, Dostert C, Staehli F, Cabalzar K, Castillo R, Tardivel A, Schneider P, Tschopp J
    Nature, 2009;460(7252):269-73.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  144. Cure of established GL261 mouse gliomas after combined immunotherapy with GM-CSF and IFNgamma is mediated by both CD8+ and CD4+ T-cells.
    Authors: Smith KE, Fritzell S, Badn W, Eberstal S, Janelidze S, Visse E, Darabi A, Siesjo P
    Int. J. Cancer, 2009;124(3):630-7.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  145. Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10.
    Authors: Ilarregui JM, Croci DO, Bianco GA, Toscano MA, Salatino M, Vermeulen ME, Geffner JR, Rabinovich GA
    Nat. Immunol., 2009;10(9):981-91.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  146. Effects of Signal 3 during CD8 T cell priming: Bystander production of IL-12 enhances effector T cell expansion but promotes terminal differentiation.
    Authors: Cui W, Joshi NS, Jiang A, Kaech SM
    Vaccine, 2009;27(15):2177-87.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  147. E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection.
    Authors: Aronoff DM, Lewis C, Serezani CH, Eaton KA, Goel D, Phipps JC, Peters-Golden M, Mancuso P
    J. Immunol., 2009;183(4):2642-9.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  148. IFN-gamma down-regulates Secretoglobin 3A1 gene expression.
    Authors: Yamada A, Suzuki D, Miyazono A, Oshima K, Kamiya A, Zhao B, Takami M, Donnelly RP, Itabe H, Yamamoto M, Kimura S, Kamijo R
    Biochem. Biophys. Res. Commun., 2009;379(4):964-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  149. Interferon-gamma limits the availability of iron for intramacrophage Salmonella typhimurium.
    Authors: Nairz M, Fritsche G, Brunner P, Talasz H, Hantke K, Weiss G
    Eur. J. Immunol., 2008;38(7):1923-36.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  150. Protein Never in Mitosis Gene A Interacting-1 (PIN1) regulates degradation of inducible nitric oxide synthase in endothelial cells.
    Authors: Liu T, Huang Y, Likhotvorik RI, Keshvara L, Hoyt DG
    Am. J. Physiol., Cell Physiol., 2008;295(3):C819-27.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  151. CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis.
    Authors: Wieland CW, van der Windt GJ, Wiersinga WJ, Florquin S, van der Poll T
    Immunology, 2008;125(2):272-9.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  152. Elevated neuronal expression of CD200 protects Wlds mice from inflammation-mediated neurodegeneration.
    Authors: Chitnis T, Imitola J, Wang Y, Elyaman W, Chawla P, Sharuk M, Raddassi K, Bronson RT, Khoury SJ
    Am. J. Pathol., 2007;170(5):1695-712.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  153. Differential ex vivo nitric oxide production by acutely isolated neonatal and adult microglia.
    Authors: Schell JB, Crane CA, Smith MF, Roberts MR
    J. Neuroimmunol., 2007;189(1):75-87.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  154. The direct action of 1alpha,25(OH)2-vitamin D3 on purified mouse Langerhans cells.
    Authors: Fujita H, Asahina A, Komine M, Tamaki K
    Cell. Immunol., 2007;245(2):70-9.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  155. IFN-gamma production during initial infection determines the outcome of reinfection with respiratory syncytial virus.
    Authors: Lee YM, Miyahara N, Takeda K, Prpich J, Oh A, Balhorn A, Joetham A, Gelfand EW, Dakhama A
    Am. J. Respir. Crit. Care Med., 2007;177(2):208-18.
  156. Maternal immune activation alters fetal brain development through interleukin-6.
    Authors: Smith SE, Li J, Garbett K, Mirnics K, Patterson PH
    J. Neurosci., 2007;27(40):10695-702.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  157. Differential Growth of IFN-beta-Engineered Tumor Cells in Nude and IFN Receptor-Null Mice.
    Authors: Zhang F, Lee J, Wang D, Dong Z
    J. Interferon Cytokine Res., 2006;26(2):108-18.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  158. Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1.
    Authors: Butovsky O, Koronyo-Hamaoui M, Kunis G, Ophir E, Landa G, Cohen H, Schwartz M
    Proc. Natl. Acad. Sci. U.S.A., 2006;103(31):11784-9.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  159. Glechoma hederacea inhibits inflammatory mediator release in IFN-gamma and LPS-stimulated mouse peritoneal macrophages.
    Authors: An HJ, Jeong HJ, Um JY, Kim HM, Hong SH
    J Ethnopharmacol, 2006;106(3):418-24.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  160. Targeted deletion of CCR2 impairs deep vein thombosis resolution in a mouse model.
    Authors: Henke PK, Pearce CG, Moaveni DM, Moore AJ, Lynch EM, Longo C, Varma M, Dewyer NA, Deatrick KB, Upchurch GR, Wakefield TW, Hogaboam C, Kunkel SL
    J. Immunol., 2006;177(5):3388-97.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  161. Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis.
    Authors: Butovsky O, Landa G, Kunis G, Ziv Y, Avidan H, Greenberg N, Schwartz A, Smirnov I, Pollack A, Jung S, Schwartz M
    J. Clin. Invest., 2006;116(4):905-15.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  162. Overexpression of suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis.
    Authors: Watanabe H, Kubo M, Numata K, Takagi K, Mizuta H, Okada S, Ito T, Matsukawa A
    J. Immunol., 2006;177(12):8650-7.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  163. Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells.
    Authors: Butovsky O, Ziv Y, Schwartz A, Landa G, Talpalar AE, Pluchino S, Martino G, Schwartz M
    Mol. Cell. Neurosci., 2006;31(1):149-60.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  164. Dendritic cells and NK cells stimulate bystander T cell activation in response to TLR agonists through secretion of IFN-alpha beta and IFN-gamma.
    Authors: Kamath AT, Sheasby CE, Tough DF
    J. Immunol., 2005;174(2):767-76.
    Species: Mouse
    Sample Type: Cell Culture Supernates
    Application: Bioassay
  165. Sequential ELISA to profile multiple cytokines from small volumes.
    Authors: Osuchowski MF, Siddiqui J, Copeland S, Remick DG
    J. Immunol. Methods, 2005;302(1):172-81.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  166. Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist.
    Authors: Best SM, Morris KL, Shannon JG, Robertson SJ, Mitzel DN, Park GS, Boer E, Wolfinbarger JB, Bloom ME
    J. Virol., 2005;79(20):12828-39.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  167. IFN-alpha priming results in a gain of proinflammatory function by IL-10: implications for systemic lupus erythematosus pathogenesis.
    Authors: Sharif MN, Tassiulas I, Hu Y, Mecklenbrauker I, Tarakhovsky A, Ivashkiv LB
    J. Immunol., 2004;172(10):6476-81.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  168. Increased and long-term generation of dendritic cells with reduced function from IL-6-deficient bone marrow.
    Authors: Bleier JI, Pillarisetty VG, Shah AB, DeMatteo RP
    J. Immunol., 2004;172(12):7408-16.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  169. IL-22 increases the innate immunity of tissues.
    Authors: Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R
    Immunity, 2004;21(2):241-54.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  170. A disintegrin and metalloproteinase 10-mediated cleavage and shedding regulates the cell surface expression of CXC chemokine ligand 16.
    Authors: Gough PJ, Garton KJ, Wille PT, Rychlewski M, Dempsey PJ, Raines EW
    J. Immunol., 2004;172(6):3678-85.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  171. Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection.
    Authors: Zamboni DS, Campos MA, Torrecilhas AC, Kiss K, Samuel JE, Golenbock DT, Lauw FN, Roy CR, Almeida IC, Gazzinelli RT
    J. Biol. Chem., 2004;279(52):54405-15.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  172. Gamma interferon does not enhance clearance of Pseudomonas aeruginosa but does amplify a proinflammatory response in a murine model of postseptic immunosuppression.
    Authors: Murphey ED, Herndon DN, Sherwood ER
    Infect. Immun., 2004;72(12):6892-901.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  173. Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor.
    Authors: Shin T, Kennedy G, Gorski K, Tsuchiya H, Koseki H, Azuma M, Yagita H, Chen L, Powell J, Pardoll D, Housseau F
    J. Exp. Med., 2003;198(1):31-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  174. Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody.
    Authors: Asselin-Paturel C, Brizard G, Pin JJ, Briere F, Trinchieri G
    J. Immunol., 2003;171(12):6466-77.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  175. Intracellular thiols contribute to Th2 function via a positive role in IL-4 production.
    Authors: Monick MM, Samavati L, Butler NS, Mohning M, Powers LS, Yarovinsky T, Spitz DR, Hunninghake GW
    J. Immunol., 2003;171(10):5107-15.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  176. Impact of interleukin-13 responsiveness on the synthetic and proliferative properties of Th1- and Th2-type pulmonary granuloma fibroblasts.
    Authors: Jakubzick C, Choi ES, Kunkel SL, Joshi BH, Puri RK, Hogaboam CM
    Am. J. Pathol., 2003;162(5):1475-86.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  177. IFN-gamma, but not Fas, mediates reduction of allergen-induced mucous cell metaplasia by inducing apoptosis.
    Authors: Shi ZO, Fischer MJ, De Sanctis GT, Schuyler MR, Tesfaigzi Y
    J. Immunol., 2002;168(9):4764-71.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  178. TGFbeta2-mediated production of hyaluronan is important for the induction of epicardial cell differentiation and invasion.
    Authors: Craig EA, Craig E, Austin A, Austin AF, Vaillancourt RR, Vaillancourt R, Barnett JV, Camenisch T, Camenisch TD
    Exp Cell Res, 0;316(20):3397-405.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
Expand to show all 178 Citations

Have you used Recombinant Mouse IFN-gamma Protein, CF?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Order Details

  • Formulations

Contact Information

Calculators

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷
R&D Systems Guarantee

Feedback

Customer Information