Recombinant Mouse IL-23 Protein

Formulations:
Catalog # Availability Size / Price Qty
1887-ML-010
Product Details
Citations (138)
FAQs
Supplemental Products
Reviews (4)

Recombinant Mouse IL-23 Protein Summary

Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to induce IL-17 secretion by mouse splenocytes. Aggarwal, S. et al. (2003) J. Biol. Chem. 278:1910. The ED50 for this effect is 0.05-0.25 ng/mL.
Source
Spodoptera frugiperda, Sf 21 (stably transfected)-derived mouse IL-23 protein
Mouse IL-23 p40
(Met23-Ser335)
Accession # P43432
IGSGSSRGGSGSGGSGGGGSK Mouse IL-23 p19
(Leu20-Ala196)
Accession # Q9EQ14
N-terminus C-terminus
N-terminal Sequence
Analysis
Met23
Predicted Molecular Mass
57 kDa
SDS-PAGE
(58-71) kDa, non-reducing conditions

Product Datasheets

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

1887-ML

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

1887-ML/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IL-23

Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 (1-5). The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Mouse p19 cDNA encodes a 196 amino acid residue (aa) precursor protein with a putative 19 aa signal peptide and 177 aa mature protein. Human and mouse p19 share 70% aa sequence identity. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R). IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naïve and memory human Tnbsp;cells, the effects of IL-23 is restricted to memory T cells. In mouse, IL-23 but not IL-12, has also been shown to induce memory T cells to secret IL-17, a potent proinflammatory cytokine. IL-12 and IL-23 can induce IL-12 production from mouse splenic DC of both the CD8- and CD8+ subtypes, however only IL-23 can act directly on CD8+ DC to mediate immunogenic presentation of poorly immunogenic tumor/self peptide.

References
  1. Oppmann, B. et al. (2000) Immunity 13:715.
  2. Lankford, C.S. and D.M. Frucht (2003) J. Leukoc. Biol. 73:49.
  3. Parham, C. et al. (2002) J. Immunol. 168:5699.
  4. Belladonna, M.L. et al. (2002) J. Immunol. 168:5448.
  5. Aggarwal, S. et al. (2003) J. Biol. Chem. 278:1910.
Long Name
Interleukin 23
Entrez Gene IDs
51561 (Human); 83430 (Mouse); 155140 (Rat)
Alternate Names
IL-23 p19/IL-12 p40; IL23; IL-23; IL-23A; IL-23-A; IL-23p19; IL-23p19/IL-12p40; IL23P19P19; interleukin 23 p19 subunit; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; Interleukin-23 subunit p19; JKA3 induced upon T-cell activation; MGC79388; SGRF; SGRFIL-23 subunit alpha

Citations for Recombinant Mouse IL-23 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

138 Citations: Showing 1 - 10
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  1. IL-1 and TNF? Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration
    Authors: H Katsura, Y Kobayashi, PR Tata, BLM Hogan
    Stem Cell Reports, 2019;0(0):.
    Species: Mouse
    Sample Types: Organoids
    Applications: Bioassay
  2. Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation
    Authors: K Yasuda, Y Kitagawa, R Kawakami, Y Isaka, H Watanabe, G Kondoh, T Kohwi-Shig, S Sakaguchi, K Hirota
    Nat Commun, 2019;10(1):549.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. NCR- group 3 innate lymphoid cells orchestrate IL-23/IL-17 axis to promote hepatocellular carcinoma development
    Authors: Y Liu, Y Song, D Lin, L Lei, Y Mei, Z Jin, H Gong, Y Zhu, B Hu, Y Zhang, L Zhao, HY Teo, J Qiu, W Jiang, C Dong, D Wu, Y Huang, H Liu
    EBioMedicine, 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
  4. Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis
    Authors: A Abdullah, M Maged, I Hairul-Isl, A Osama I, H Maha, A Manal, H Hamza
    PLoS ONE, 2019;14(4):e0215981.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. cIAP1/2 inhibition synergizes with TNF inhibition in autoimmunity by down-regulating IL-17A and inducing Tregs
    Authors: JZ Kawalkowsk, J Ogbechi, PJ Venables, RO Williams
    Sci Adv, 2019;5(5):eaaw5422.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Retinal microglia initiate neuroinflammation in ocular autoimmunity
    Authors: Y Okunuki, R Mukai, T Nakao, SJ Tabor, O Butovsky, R Dana, BR Ksander, KM Connor
    Proc. Natl. Acad. Sci. U.S.A., 2019;0(0):.
  7. Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation
    Authors: AO Bamidele, PA Svingen, MR Sagstetter, OF Sarmento, M Gonzalez, MB Braga Neto, S Kugathasan, G Lomberk, RA Urrutia, WA Faubion
    Cell Mol Gastroenterol Hepatol, 2019;7(1):55-71.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis
    Authors: HG Lee, JU Lee, DH Kim, S Lim, I Kang, JM Choi
    Nat Commun, 2019;10(1):709.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis
    Authors: KL Graham, BJ Werner, KM Moyer, AK Patton, CR Krois, HS Yoo, M Tverskoy, M LaJevic, JL Napoli, RA Sobel, BA Zabel, EC Butcher
    Proc. Natl. Acad. Sci. U.S.A., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus
    Authors: J Breuer, E Korpos, MJ Hannocks, T Schneider-, J Song, L Zondler, S Herich, K Flanagan, T Korn, A Zarbock, T Kuhlmann, L Sorokin, H Wiendl, N Schwab
    J Neuroinflammation, 2018;15(1):236.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  11. A cytokine network involving IL-36?, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage
    Authors: VL Ngo, H Abo, E Maxim, A Harusato, D Geem, O Medina-Con, D Merlin, AT Gewirtz, A Nusrat, TL Denning
    Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  12. Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1
    Authors: G Meyer Zu H, D Przybylski, MA Schramm, C Wang, A Schnell, Y Lee, R Sobel, A Regev, VK Kuchroo
    Immunity, 2018;48(3):556-569.e7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation
    Authors: R Wu, J Zeng, J Yuan, X Deng, Y Huang, L Chen, P Zhang, H Feng, Z Liu, Z Wang, X Gao, H Wu, H Wang, Y Su, M Zhao, Q Lu
    J. Clin. Invest., 2018;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  14. NCR+ ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 stimulation in mice
    Authors: Y Mikami, G Scarno, B Zitti, HY Shih, Y Kanno, A Santoni, JJ O'Shea, G Sciumè
    Eur. J. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Characterization and allergic role of IL-33-induced neutrophil polarization
    Authors: B Sun, L Zhu, Y Tao, HX Sun, Y Li, P Wang, Y Hou, Y Zhao, X Zhang, L Zhang, N Na, Y Zhao
    Cell. Mol. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28
    Authors: Y Jiang, Y Liu, H Lu, SC Sun, W Jin, X Wang, C Dong
    Nat Commun, 2018;9(1):1424.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses
    Authors: CN Berger, VF Crepin, TI Roumelioti, JC Wright, N Serafini, M Pevsner-Fi, L Yu, E Elinav, JP Di Santo, JS Choudhary, G Frankel
    PLoS Pathog., 2018;14(10):e1007406.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  18. GLK-IKK? signaling induces dimerization and translocation of the AhR-ROR?t complex in IL-17A induction and autoimmune disease
    Authors: HC Chuang, CY Tsai, CH Hsueh, TH Tan
    Sci Adv, 2018;4(9):eaat5401.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. TGF?1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of TH17 cells by an AHR-independent mechanism
    Authors: KA de Lima, PB Donate, J Talbot, M Davoli-Fer, RS Peres, TM Cunha, JC Alves-Filh, FQ Cunha
    Cell Death Dis, 2018;9(11):1130.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation
    Authors: CJ Zhang, M Jiang, H Zhou, W Liu, C Wang, Z Kang, B Han, Q Zhang, X Chen, J Xiao, A Fisher, WJ Kaiser, MA Murayama, Y Iwakura, J Gao, J Carman, A Dongre, G Dubyak, DW Abbott, FD Shi, RM Ransohoff, X Li
    J. Clin. Invest., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. IL-25 enhances Th17 cell-mediated contact dermatitis by promoting IL-1? production by dermal dendritic cells
    Authors: H Suto, A Nambu, H Morita, S Yamaguchi, T Numata, T Yoshizaki, E Shimura, K Arae, Y Asada, K Motomura, M Kaneko, T Abe, A Matsuda, Y Iwakura, K Okumura, H Saito, K Matsumoto, K Sudo, S Nakae
    J. Allergy Clin. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  22. STAT-3-independent production of IL-17 by mouse innate-like ?? T cells controls ocular infection
    Authors: AJ St Leger, AM Hansen, H Karauzum, R Horai, CR Yu, A Laurence, KD Mayer-Barb, P Silver, R Villasmil, C Egwuagu, SK Datta, RR Caspi
    J. Exp. Med., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. ??TCR regulates production of interleukin-27 by neutrophils and attenuates inflammatory arthritis
    Authors: L Bouchareyc, EM Grössinger, M Kang, IE Adamopoulo
    Sci Rep, 2018;8(1):7590.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  24. IL-23-induced macrophage polarization and its pathological roles in mice with imiquimod-induced psoriasis
    Authors: Y Hou, L Zhu, H Tian, HX Sun, R Wang, L Zhang, Y Zhao
    Protein Cell, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. REV-ERB? Regulates TH17 Cell Development and Autoimmunity
    Authors: M Amir, S Chaudhari, R Wang, S Campbell, SA Mosure, LB Chopp, Q Lu, J Shang, OB Pelletier, Y He, C Doebelin, MD Cameron, DJ Kojetin, TM Kamenecka, LA Solt
    Cell Rep, 2018;25(13):3733-3749.e8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit
    Authors: Y Arima, T Ohki, N Nishikawa, K Higuchi, M Ota, Y Tanaka, J Nio-Kobaya, M Elfeky, R Sakai, Y Mori, T Kawamoto, A Stofkova, Y Sakashita, Y Morimoto, M Kuwatani, T Iwanaga, Y Yoshioka, N Sakamoto, A Yoshimura, M Takiguchi, S Sakoda, M Prinz, D Kamimura, M Murakami
    Elife, 2017;6(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Viral RNA-Unprimed Rig-I Restrains Stat3 Activation in the Modulation of Regulatory T Cell/Th17 Cell Balance
    Authors: H Yang, HZ Guo, XY Li, J Lin, W Zhang, JM Zhao, HX Zhang, SJ Chen, Z Chen, J Zhu
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. GM-CSF is not essential for experimental autoimmune encephalomyelitis but promotes brain-targeted disease
    Authors: ER Pierson, JM Goverman
    JCI Insight, 2017;2(7):e92362.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis
    Authors: L Franchi, I Monteleone, LY Hao, MA Spahr, W Zhao, X Liu, K Demock, A Kulkarni, CA Lesch, B Sanchez, L Carter, I Marafini, X Hu, O Mashadova, M Yuan, JM Asara, H Singh, CA Lyssiotis, G Monteleone, AW Opipari, GD Glick
    J. Immunol, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis
    Authors: MA L‚cuyer, O Saint-Laur, L BourbonniŠ, S Larouche, C Larochelle, L Michel, M Charabati, M Abadier, S Zandee, N Haghayegh, E Gowing, C Pittet, R Lyck, B Engelhardt, A Prat
    Proc. Natl. Acad. Sci. U.S.A, 2017;114(4):E524-E533.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Protein Tyrosine Phosphatase PTPN22 regulates IL-1? dependent Th17 responses by modulating dectin-1 signaling in mice
    Authors: HA Purvis, F Clarke, CK Jordan, CS Blanco, GH Cornish, X Dai, DJ Rawlings, R Zamoyska, AP Cope
    Eur. J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Hypomorphic A20 expression confers susceptibility to psoriasis
    Authors: A Aki, M Nagasaki, BA Malynn, A Ma, T Kagari
    PLoS ONE, 2017;12(6):e0180481.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  33. Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1
    Authors: G Fu, Q Xu, Y Qiu, X Jin, T Xu, S Dong, J Wang, Y Ke, H Hu, X Cao, D Wang, H Cantor, X Gao, L Lu
    J. Exp. Med., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  34. The STAT4/MLL1 Epigenetic Axis Regulates the Antimicrobial Functions of Murine Macrophages
    Authors: WF Carson, KA Cavassani, EM Soares, S Hirai, NA Kittan, MA Schaller, MM Scola, A Joshi, A Matsukawa, DM Aronoff, CN Johnson, Y Dou, KA Gallagher, SL Kunkel
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota
    Authors: Q Zhao, SN Harbour, R Kolde, IJ Latorre, HM Tun, TR Schoeb, H Turner, JJ Moon, E Khafipour, RJ Xavier, CT Weaver, CO Elson
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. GM-CSF Promotes Chronic Disability in Experimental Autoimmune Encephalomyelitis by Altering the Composition of Central Nervous System-Infiltrating Cells, but Is Dispensable for Disease Induction
    Authors: PC Duncker, JS Stoolman, AK Huber, BM Segal
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression
    Authors: Z Hao, Y Sheng, GS Duncan, WY Li, C Dominguez, J Sylvester, YW Su, GH Lin, BE Snow, D Brenner, A You-Ten, J Haight, S Inoue, A Wakeham, A Elford, S Hamilton, Y Liang, JC Z£¤iga-Pfl, HH He, PS Ohashi, TW Mak
    Nat Commun, 2017;8(0):14003.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. The excretory-secretory products of Echinococcus granulosus protoscoleces directly regulate the differentiation of B10, B17 and Th17 cells
    Authors: W Pan, WT Hao, YJ Shen, XY Li, YJ Wang, FF Sun, JH Yin, J Zhang, RX Tang, JP Cao, KY Zheng
    Parasit Vectors, 2017;10(1):348.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Suppressive IL-17A(+)Foxp3(+) and ex-Th17 IL-17A(neg)Foxp3(+) Treg cells are a source of tumour-associated Treg cells
    Authors: S Downs-Cann, S Berkey, GM Delgoffe, RP Edwards, T Curiel, K Odunsi, DL Bartlett, N Obermajer
    Nat Commun, 2017;8(0):14649.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  40. RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease
    Authors: H Zhu, F Lou, Q Yin, Y Gao, Y Sun, J Bai, Z Xu, Z Liu, W Cai, F Ke, L Zhang, H Zhou, H Wang, G Wang, X Chen, H Zhang, Z Wang, F Ginhoux, C Lu, B Su, H Wang
    EMBO Mol Med, 2017;9(5):589-604.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  41. A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation
    Authors: MM Montoya, J Maul, PB Singh, HH Pua, F Dahlström, N Wu, X Huang, KM Ansel, D Baumjohann
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Ndfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production
    Authors: AA Kesewa Lay, S L Sprout, D Phillips, PM Oliver
    Sci Rep, 2017;7(0):39649.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Interleukin-17A-promoted MSC2 polarization related with new bone formation of ankylosing spondylitis
    Authors: T He, Y Huang, C Zhang, D Liu, C Cheng, W Xu, X Zhang
    Oncotarget, 2017;8(57):96993-97008.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. IL-1? and IL-23 Promote Extrathymic Commitment of CD27(+)CD122(-) ?? T Cells to ??T17 Cells
    Authors: A Muschaweck, F Petermann, T Korn
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  45. IL-23 Limits the Production of IL-2 and Promotes Autoimmunity in Lupus
    Authors: H Dai, F He, GC Tsokos, VC Kyttaris
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Eomes expression reports the progressive differentiation of IFN-?-producing Th1-like ?? T cells
    Authors: CN Lino, J Barros-Mar, L Oberdörfer, T Walzer, I Prinz
    Eur. J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine
    Authors: AK Savage, HE Liang, RM Locksley
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  48. The frequency of Th17�cells in the small intestine exhibits a day-night variation dependent on circadian clock activity
    Authors: HP Thu Le, Y Nakamura, K Oh-Oka, K Ishimaru, S Nakajima, A Nakao
    Biochem. Biophys. Res. Commun., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Microbiota-derived butyrate suppresses group 3 innate lymphoid cells in terminal ileal Peyer's patches
    Authors: SH Kim, BH Cho, H Kiyono, YS Jang
    Sci Rep, 2017;7(1):3980.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis.
    Authors: Lee J, Kannarkat G, Chung J, Joon Lee H, Graham K, Tansey M
    J Neuroinflammation, 2016;13(1):24.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function
    Proc Natl Acad Sci USA, 2016;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  52. IL-1-induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation.
    Authors: Chih-Chung Lin, Tara R Bradstree, Elizabeth A Schwarzko, Nicholas N Jarjour, Chun Chou, Angela S Archambau, Julia Sim, Bernd H Zinselmey, Javier A Carrero, Gregory F Wu, Reshma Taneja, Maxim N Artyomov, John H Russell, Brian T Edelson
    The Journal of Experimental Medicine, 2016;0(0):1540-9538.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Phenotypic and Functional Plasticity of Murine Intestinal NKp46+ Group 3 Innate Lymphoid Cells
    J Immunol, 2016;196(11):4731-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo.
    Authors: Velazquez F, Grodecki-Pena A, Knapp A, Salvador A, Nevers T, Croce K, Alcaide P
    J Immunol, 2016;196(3):1305-16.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis
    Sci Rep, 2016;6(0):37977.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  56. Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU)
    PLoS ONE, 2016;11(5):e0155953.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses
    Authors: LN Guthrie, K Abiraman, ES Plyler, NT Sprenkle, SA Gibson, BC McFarland, R Rajbhandar, AL Rowse, EN Benveniste, GP Meares
    J. Biol. Chem., 2016;291(30):15830-40.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Dose-Dependent Suppression of Cytokine production from T cells by a Novel Phosphoinositide 3-Kinase Delta Inhibitor
    Sci Rep, 2016;6(0):30384.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Myelin-specific Th17 cells induce severe relapsing optic neuritis with irreversible loss of retinal ganglion cells in C57BL/6 mice
    Authors: CM Larabee, Y Hu, S Desai, C Georgescu, JD Wren, RC Axtell, SM Plafker
    Mol Vis, 2016;22(0):332-41.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells
    Authors: CE O'Leary, CR Riling, LA Spruce, H Ding, S Kumar, G Deng, Y Liu, SH Seeholzer, PM Oliver
    Nat Commun, 2016;7(0):11226.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response
    Authors: Shweta Pasi
    J Biol Chem, 2016;291(23):12358-69.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  62. SLAM-associated protein favours the development of iNKT2 over iNKT17 cells
    Authors: Marie-Laure Michel
    Eur J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Cutting edge: c-Kit signaling differentially regulates type 2 innate lymphoid cell accumulation and susceptibility to central nervous system demyelination in male and female SJL mice.
    Authors: Russi A, Walker-Caulfield M, Ebel M, Brown M
    J Immunol, 2015;194(12):5609-13.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection.
    Authors: Munoz M, Eidenschenk C, Ota N, Wong K, Lohmann U, Kuhl A, Wang X, Manzanillo P, Li Y, Rutz S, Zheng Y, Diehl L, Kayagaki N, van Lookeren-Campagne M, Liesenfeld O, Heimesaat M, Ouyang W
    Immunity, 2015;42(2):321-31.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  65. A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine.
    Authors: Dunne A, Mielke L, Allen A, Sutton C, Higgs R, Cunningham C, Higgins S, Mills K
    Mucosal Immunol, 2015;8(3):607-17.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  66. IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
    Authors: Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, Pear W, Hatton R, Weaver C
    Nat Immunol, 2015;16(3):286-95.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells.
    Authors: Kim Y, Lim H, Jung H, Wetsel R, Chung Y
    PLoS ONE, 2015;10(3):e0120294.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  68. CXCL13 antibody for the treatment of autoimmune disorders.
    Authors: Klimatcheva E, Pandina T, Reilly C, Torno S, Bussler H, Scrivens M, Jonason A, Mallow C, Doherty M, Paris M, Smith E, Zauderer M
    BMC Immunol, 2015;16(0):6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Adaptive Immune-like gamma/delta T Lymphocytes Share Many Common Features with Their alpha/beta T Cell Counterparts.
    Authors: Lombes A, Durand A, Charvet C, Riviere M, Bonilla N, Auffray C, Lucas B, Martin B
    J Immunol, 2015;195(4):1449-58.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Composition, Development, and Function of Uterine Innate Lymphoid Cells.
    Authors: Doisne J, Balmas E, Boulenouar S, Gaynor L, Kieckbusch J, Gardner L, Hawkes D, Barbara C, Sharkey A, Brady H, Brosens J, Moffett A, Colucci F
    J Immunol, 2015;195(8):3937-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  71. TGF-beta3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses.
    Authors: Okamura T, Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, Komai T, Shoda H, Miyazaki J, Fujio K, Yamamoto K
    Nat Commun, 2015;6(0):6329.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Testosterone suppresses hepatic inflammation by the downregulation of IL-17, CXCL-9, and CXCL-10 in a mouse model of experimental acute cholangitis.
    Authors: Schwinge D, Carambia A, Quaas A, Krech T, Wegscheid C, Tiegs G, Prinz I, Lohse A, Herkel J, Schramm C
    J Immunol, 2015;194(6):2522-30.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  73. miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim.
    Authors: Haftmann C, Stittrich A, Zimmermann J, Fang Z, Hradilkova K, Bardua M, Westendorf K, Heinz G, Riedel R, Siede J, Lehmann K, Weinberger E, Zimmel D, Lauer U, Haupl T, Sieper J, Backhaus M, Neumann C, Hoffmann U, Porstner M, Chen W, Grun J, Baumgrass R, Matz M, Lohning M, Scheffold A, Wittmann J, Chang H, Rajewsky N, Jack H, Radbruch A, Mashreghi M
    Eur J Immunol, 2015;45(4):1192-205.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier.
    Authors: Abadier M, Haghayegh Jahromi N, Cardoso Alves L, Boscacci R, Vestweber D, Barnum S, Deutsch U, Engelhardt B, Lyck R
    Eur J Immunol, 2015;45(4):1043-58.
  75. Interleukin-36gamma is expressed by neutrophils and can activate microglia, but has no role in experimental autoimmune encephalomyelitis.
    Authors: Bozoyan L, Dumas A, Patenaude A, Vallieres L
    J Neuroinflammation, 2015;12(0):173.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Temporal expression of growth factors triggered by epiregulin regulates inflammation development.
    Authors: Harada M, Kamimura D, Arima Y, Kohsaka H, Nakatsuji Y, Nishida M, Atsumi T, Meng J, Bando H, Singh R, Sabharwal L, Jiang J, Kumai N, Miyasaka N, Sakoda S, Yamauchi-Takihara K, Ogura H, Hirano T, Murakami M
    J Immunol, 2015;194(3):1039-46.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  77. An A2B Adenosine Receptor Agonist Promotes Th17 Autoimmune Responses in Experimental Autoimmune Uveitis (EAU) via Dendritic Cell Activation.
    Authors: Chen M, Liang D, Zuo A, Shao H, Kaplan H, Sun D
    PLoS ONE, 2015;10(7):e0132348.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Tolerance of activated pathogenic CD4+ T cells by transcriptional targeting of dendritic cells.
    Authors: de Andrade Pereira B, Ackermann M, Chaudhary S, Vogel R, Vogt B, Dresch C, Fraefel C
    Gene Ther, 2015;22(5):382-90.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Immune requirements for protective Th17 recall responses to Mycobacterium tuberculosis challenge.
    Authors: Monin L, Griffiths K, Slight S, Lin Y, Rangel-Moreno J, Khader S
    Mucosal Immunol, 2015;8(5):1099-109.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Dysbiosis caused by vitamin D receptor deficiency confers colonization resistance to Citrobacter rodentium through modulation of innate lymphoid cells.
    Authors: Chen J, Waddell A, Lin Y, Cantorna M
    Mucosal Immunol, 2015;8(3):618-26.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  81. B cells promote induction of experimental autoimmune encephalomyelitis by facilitating reactivation of T cells in the central nervous system.
    Authors: Pierson E, Stromnes I, Goverman J
    J Immunol, 2014;192(3):929-39.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  82. miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting RORgammat and STAT3.
    Authors: Zhu E, Wang X, Zheng B, Wang Q, Hao J, Chen S, Zhao Q, Zhao L, Wu Z, Yin Z
    J Immunol, 2014;192(12):5599-609.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Th1 polarization of T cells injected into the cerebrospinal fluid induces brain immunosurveillance.
    Authors: Fisher Y, Strominger I, Biton S, Nemirovsky A, Baron R, Monsonego A
    J Immunol, 2014;192(1):92-102.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  84. Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-beta-induced Foxp3 expression.
    Authors: Ikeda S, Saijo S, Murayama M, Shimizu K, Akitsu A, Iwakura Y
    J Immunol, 2014;192(4):1449-58.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  85. Brain glycolipids suppress T helper cells and inhibit autoimmune demyelination.
    Authors: Mycko M, Sliwinska B, Cichalewska M, Cwiklinska H, Raine C, Selmaj K
    J Neurosci, 2014;34(25):8646-58.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis.
    Authors: Liu Y, Holdbrooks A, De Sarno P, Rowse A, Yanagisawa L, McFarland B, Harrington L, Raman C, Sabbaj S, Benveniste E, Qin H
    J Immunol, 2014;192(1):59-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses.
    Authors: Ashino S, Takeda K, Li H, Taylor V, Joetham A, Pine P, Gelfand E
    J Allergy Clin Immunol, 2014;133(4):1162-74.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  88. The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-gamma-producing T helper 17 cells.
    Authors: Wang Y, Godec J, Ben-Aissa K, Cui K, Zhao K, Pucsek A, Lee Y, Weaver C, Yagi R, Lazarevic V
    Immunity, 2014;40(3):355-66.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  89. Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase.
    Authors: Sriskantharajah S, Guckel E, Tsakiri N, Kierdorf K, Brender C, Ben-Addi A, Veldhoen M, Tsichlis P, Stockinger B, O'Garra A, Prinz M, Kollias G, Ley S
    J Immunol, 2014;192(8):3518-29.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  90. The alarmin IL-33 promotes regulatory T-cell function in the intestine.
    Authors: Schiering C, Krausgruber T, Chomka A, Frohlich A, Adelmann K, Wohlfert E, Pott J, Griseri T, Bollrath J, Hegazy A, Harrison O, Owens B, Lohning M, Belkaid Y, Fallon P, Powrie F
    Nature, 2014;513(7519):564-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  91. Mesenchymal stem cells differentially modulate effector CD8+ T cell subsets and exacerbate experimental autoimmune encephalomyelitis.
    Authors: Glenn J, Smith M, Calabresi P, Whartenby K
    Stem Cells, 2014;32(10):2744-55.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  92. Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation.
    Authors: Yang C, Li J, Chiu L, Lan J, Chen D, Chuang H, Huang C, Tan T
    J Immunol, 2014;192(4):1547-57.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  93. Role of Blimp-1 in programing Th effector cells into IL-10 producers.
    Authors: Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi M, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kuhl A, Heimesaat M, Esser C, Im S, Radbruch A, Rutz S, Scheffold A
    J Exp Med, 2014;211(9):1807-19.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  94. Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection.
    Authors: Guo X, Qiu J, Tu T, Yang X, Deng L, Anders R, Zhou L, Fu Y
    Immunity, 2014;40(1):25-39.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  95. Regulation of T cell motility in vitro and in vivo by LPA and LPA2.
    Authors: Knowlden S, Capece T, Popovic M, Chapman T, Rezaee F, Kim M, Georas S
    PLoS ONE, 2014;9(7):e101655.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  96. CD49a promotes T-cell-mediated hepatitis by driving T helper 1 cytokine and interleukin-17 production.
    Authors: Chen Y, Peng H, Chen Y, Wei H, Sun R, Tian Z
    Immunology, 2014;141(3):388-400.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.
    Authors: Reynolds C, Chong D, Raynsford E, Quigley K, Kelly D, Llewellyn-Hughes J, Altmann D, Boyton R
    BMC Biol, 2014;12(0):32.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  98. IL-21 induces IL-22 production in CD4+ T cells.
    Authors: Yeste A, Mascanfroni I, Nadeau M, Burns E, Tukpah A, Santiago A, Wu C, Patel B, Kumar D, Quintana F
    Nat Commun, 2014;5(0):3753.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Differential IL-10 production by DCs determines the distinct adjuvant effects of LPS and PTX in EAE induction.
    Authors: Zhou H, Wang Y, Lian Q, Yang B, Ma Y, Wu X, Sun S, Liu Y, Sun B
    Eur J Immunol, 2014;44(5):1352-62.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  100. The inhibitory effect of IFN-gamma on protease HTRA1 expression in rheumatoid arthritis.
    Authors: Hou Y, Lin H, Zhu L, Liu Z, Hu F, Shi J, Yang T, Shi X, Guo H, Tan X, Zhang L, Wang Q, Li Z, Zhao Y
    J Immunol, 2014;193(1):130-8.
  101. IL-22-producing RORgammat-dependent innate lymphoid cells play a novel protective role in murine acute hepatitis.
    Authors: Matsumoto A, Kanai T, Mikami Y, Chu P, Nakamoto N, Ebinuma H, Saito H, Sato T, Yagita H, Hibi T
    PLoS ONE, 2013;8(4):e62853.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  102. Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation.
    Authors: Yanaba K, Kamata M, Ishiura N, Shibata S, Asano Y, Tada Y, Sugaya M, Kadono T, Tedder T, Sato S
    J Leukoc Biol, 2013;94(4):563-73.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  103. ERK differentially regulates Th17- and Treg-cell development and contributes to the pathogenesis of colitis.
    Authors: Liu H, Yao S, Dann S, Qin H, Elson C, Cong Y
    Eur J Immunol, 2013;43(7):1716-26.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  104. IL-23 protection against Plasmodium berghei infection in mice is partially dependent on IL-17 from macrophages.
    Authors: Ishida H, Imai T, Suzue K, Hirai M, Taniguchi T, Yoshimura A, Iwakura Y, Okada H, Suzuki T, Shimokawa C, Hisaeda H
    Eur J Immunol, 2013;43(10):2696-706.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  105. Posttranscriptional gene regulation of IL-17 by the RNA-binding protein HuR is required for initiation of experimental autoimmune encephalomyelitis.
    Authors: Chen J, Cascio J, Magee J, Techasintana P, Gubin M, Dahm G, Calaluce R, Yu S, Atasoy U
    J Immunol, 2013;191(11):5441-50.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  106. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
    Authors: Mascanfroni, Ivan D, Yeste, Ada, Vieira, Silvio M, Burns, Evan J, Patel, Bonny, Sloma, Ido, Wu, Yan, Mayo, Lior, Ben-Hamo, Rotem, Efroni, Sol, Kuchroo, Vijay K, Robson, Simon C, Quintana, Francisc
    Nat Immunol, 2013;14(10):1054-63.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  107. Autoreactive Th1 cells activate monocytes to support regional Th17 responses in inflammatory arthritis.
    Authors: Simons D, Oh S, Kropf E, Aitken M, Garcia V, Basehoar A, Caton A
    J Immunol, 2013;190(7):3134-41.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  108. Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatus.
    Authors: Gessner MA, Werner JL, Lilly LM, Nelson MP, Metz AE, Dunaway CW, Chan YR, Ouyang W, Brown GD, Weaver CT, Steele C
    Infect. Immun., 2012;80(1):410-7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  109. Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues.
    Authors: Casey KA, Fraser KA, Schenkel JM, Moran A, Abt MC, Beura LK, Lucas PJ, Artis D, Wherry EJ, Hogquist K, Vezys V, Masopust D
    J. Immunol., 2012;188(10):4866-75.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  110. Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS.
    Authors: Flanagan K, Fitzgerald K, Baker J
    PLoS ONE, 2012;7(7):e40443.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  111. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012;109(25):9971-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  112. Difference in Th1 and Th17 lymphocyte adhesion to endothelium.
    Authors: Alcaide P, Maganto-Garcia E, Newton G, Travers R, Croce KJ, Bu DX, Luscinskas FW, Lichtman AH
    J. Immunol., 2012;188(3):1421-30.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  113. Interleukin-23-mediated inflammation in Pseudomonas aeruginosa pulmonary infection.
    Authors: Dubin PJ, Martz A, Eisenstatt JR, Fox MD, Logar A, Kolls JK
    Infect. Immun., 2012;80(1):398-409.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  114. Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation.
    Authors: Jones GW, Stumhofer JS, Foster T, Twohig JP, Hertzog P, Topley N, Williams AS, Hunter CA, Jenkins BJ, Wang EC, Jones SA
    FASEB J., 2011;25(1):409-19.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  115. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus.
    Authors: Monticelli LA, Sonnenberg GF, Abt MC
    Nat. Immunol., 2011;12(11):1045-54.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  116. RORgammat+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota.
    Authors: Sawa S, Lochner M, Satoh-Takayama N, Dulauroy S, Berard M, Kleinschek M, Cua D, Di Santo JP, Eberl G
    Nat. Immunol., 2011;12(4):320-6.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  117. Innate immune responses to systemic Acinetobacter baumannii infection in mice: neutrophils, but not interleukin-17, mediate host resistance.
    Authors: Breslow JM, Meissler JJ, Hartzell RR
    Infect. Immun., 2011;79(8):3317-27.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Distinct Roles of IL-23 and IL-17 in the Development of Psoriasis-Like Lesions in a Mouse Model.
    Authors: Nakajima K, Kanda T, Takaishi M, Shiga T, Miyoshi K, Nakajima H, Kamijima R, Tarutani M, Benson JM, Elloso MM, Gutshall LL, Naso MF, Iwakura Y, DiGiovanni J, Sano S
    J. Immunol., 2011;186(7):4481-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  119. Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy.
    Authors: Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, Boucontet L, Apetoh L, Ghiringhelli F, Casares N, Lasarte JJ, Matsuzaki G, Ikuta K, Ryffel B, Benlagha K, Tesniere A, Ibrahim N, Dechanet-Merville J, Chaput N, Smyth MJ, Kroemer G, Zitvogel L
    J. Exp. Med., 2011;208(3):491-503.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  120. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens.
    Authors: DePaolo RW, Abadie V, Tang F
    Nature, 2011;471(7337):220-4.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Preclinical Evaluation of Local JAK1 and JAK2 Inhibition in Cutaneous Inflammation.
    Authors: Fridman JS, Scherle PA, Collins R, Burn T, Neilan CL, Hertel D, Contel N, Haley P, Thomas B, Shi J, Collier P, Rodgers JD, Shepard S, Metcalf B, Hollis G, Newton RC, Yeleswaram S, Friedman SM, Vaddi K
    J. Invest. Dermatol., 2011;131(9):1838-44.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  122. IL-22 defines a novel immune pathway of antifungal resistance.
    Authors: De Luca A, Zelante T, D'Angelo C
    Mucosal Immunol, 2010;3(4):361-73.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  123. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice.
    Authors: Cho JS, Pietras EM, Garcia NC, Ramos RI, Farzam DM, Monroe HR, Magorien JE, Blauvelt A, Kolls JK, Cheung AL, Cheng G, Modlin RL, Miller LS
    J. Clin. Invest., 2010;120(5):1762-73.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  124. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
    Authors: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
    J. Virol., 2010;84(24):12703-12.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  125. IL-23 is required for protection against systemic infection with Listeria monocytogenes.
    Authors: Meeks KD, Sieve AN, Kolls JK, Ghilardi N, Berg RE
    J. Immunol., 2009;183(12):8026-34.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  126. Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.
    Authors: Hamada H, Garcia-Hernandez Mde L, Reome JB, Misra SK, Strutt TM, McKinstry KK, Cooper AM, Swain SL, Dutton RW
    J. Immunol., 2009;182(6):3469-81.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  127. Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production.
    Authors: Lemos HP, Grespan R, Vieira SM, Cunha TM, Verri WA, Fernandes KS, Souto FO, McInnes IB, Ferreira SH, Liew FY, Cunha FQ
    Proc. Natl. Acad. Sci. U.S.A., 2009;106(14):5954-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  128. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice.
    Authors: McKinley L, Alcorn JF, Peterson A, Dupont RB, Kapadia S, Logar A, Henry A, Irvin CG, Piganelli JD, Ray A, Kolls JK
    J. Immunol., 2008;181(6):4089-97.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  129. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice.
    Authors: Guo B, Chang EY, Cheng G
    J. Clin. Invest., 2008;118(5):1680-90.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  130. Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin.
    Authors: Shinohara ML, Kim JH, Garcia VA, Cantor H
    Immunity, 2008;29(1):68-78.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  131. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells.
    Authors: Fitzgerald DC, Zhang GX, El-Behi M, Fonseca-Kelly Z, Li H, Yu S, Saris CJ, Gran B, Ciric B, Rostami A
    Nat. Immunol., 2007;8(12):1372-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  132. Functional relevance of the IL-23-IL-17 axis in lungs in vivo.
    Authors: Ivanov S, Bozinovski S, Bossios A, Valadi H, Vlahos R, Malmhall C, Sjostrand M, Kolls JK, Anderson GP, Linden A
    Am. J. Respir. Cell Mol. Biol., 2007;36(4):442-51.
  133. The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4.
    Authors: Brustle A, Heink S, Huber M, Rosenplanter C, Stadelmann C, Yu P, Arpaia E, Mak TW, Kamradt T, Lohoff M
    Nat. Immunol., 2007;8(9):958-66.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  134. Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections.
    Authors: Nakano N, Nishiyama C, Kanada S, Niwa Y, Shimokawa N, Ushio H, Nishiyama M, Okumura K, Ogawa H
    Blood, 2007;109(11):4846-55.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  135. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance.
    Authors: Zelante T, De Luca A, Bonifazi P, Montagnoli C, Bozza S, Moretti S, Belladonna ML, Vacca C, Conte C, Mosci P, Bistoni F, Puccetti P, Kastelein RA, Kopf M, Romani L
    Eur. J. Immunol., 2007;37(10):2695-706.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  136. IL-23 is required for neutrophil homeostasis in normal and neutrophilic mice.
    Authors: Smith E, Zarbock A, Stark MA, Burcin TL, Bruce AC, Foley P, Ley K
    J. Immunol., 2007;179(12):8274-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  137. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
    Authors: Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK
    Nature, 2006;441(7090):235-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  138. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.
    Authors: Harrington, Laurie E, Hatton, Robin D, Mangan, Paul R, Turner, Henriett, Murphy, Theresa, Murphy, Kenneth, Weaver, Casey T
    Nat Immunol, 2005;6(11):1123-32.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay

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Reviews for Recombinant Mouse IL-23 Protein

Average Rating: 4.8 (Based on 4 Reviews)

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Recombinant Mouse IL-23 Protein
By Anonymous on 02/07/2018
Application: Glycosylation characterization by MS

Recombinant Mouse IL-23 Protein
By Anonymous on 08/24/2017
Application: CD4+ T Cell polarization toward Th17

Recombinant Mouse IL-23 Protein
By Anonymous on 05/17/2017

T cells were differentiated in the presence of IL-6, IL-1beta, IL-23, anti-IFNg, and anti-IL-4 for 4 days. IL-22 was measured in the culture supernatant.


Recombinant Mouse IL-23 Protein
By Anonymous on 08/24/2016
Application: CellProlif
Reason for Rating: This cytokine helped for Th17 cell induction