Recombinant Mouse IL-7 Protein, CF

(54 citations)   
  • Purity
    >97%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Endotoxin Level
    <0.01 EU per 1 μg of the protein by the LAL method.
  • Activity
    Measured in a cell proliferation assay using PHA-activated human peripheral blood lymphocytes (PBL). Yokota, T. et al. (1986) Proc. Natl. Acad. Sci. USA 83:5894. The ED50 for this effect is 0.15-0.3 ng/mL.
  • Source
    E. coli-derived Glu26-Ile154, with an N-terminal Met
  • Accession #
  • N-terminal Sequence
    Analysis
    Glu26
  • Predicted Molecular Mass
    15 kDa
Carrier Free
What does CF mean?
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
What formulation is right for me?
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
407-ML/CF
 
407-ML
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute 5 µg vials at 50 µg/mL in sterile PBS. Reconstitute 25 µg or larger vials at 100 µg/mL in sterile PBS.
Reconstitution Reconstitute at 50 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Data Images
Recombinant Mouse IL-7 (Catalog # 407‑ML/CF) stimulates cell proliferation of PHA-activated human peripheral blood lymphocytes. The ED50 for this effect is 0.15-0.3 ng/mL.
1 μg/lane of Recombinant Mouse IL-7 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 17 kDa.
Background: IL-7

IL-7 (interleukin-7) is a 25 kDa cytokine of the hemopoietin family that plays important roles in lymphocyte differentiation, proliferation, and survival (1-4). Mouse IL-7 cDNA encodes 154 amino acids (aa) that include a 25 aa signal peptide (4). Mouse IL-7 shares approximately 88% aa sequence identity with rat IL-7 and 58-60% with human, equine, bovine, ovine, porcine, feline and canine IL-7. Human and mouse IL-7 exhibit cross-species activity (2, 3). IL-7 is produced by a wide variety of cells in primary and secondary lymphoid tissues, including stromal epithelial cells of the thymus, bone marrow, and intestines (1, 2, 5). Circulating IL-7 is limiting in healthy animals, but increases during lymphopenia (1, 6). IL-7 signals through a complex of the IL-7 Receptor alpha subunit (IL-7 R alpha, also known as CD127) with the common gamma chain ( gamma c) (1). The gamma c is also a subunit of the receptors for IL-2, -4, -9, -15, and -21 (1). IL-7 R alpha is expressed on double negative (CD4-CD8-) and CD4+ or CD8+ single positive naïve and memory T cells, but undergoes IL-7-mediated down‑regulation and shedding during antigen-driven T cell proliferation, and is absent on regulatory T cells (1, 2, 6-11). IL-7 contributes to the maintenance of all naïve and memory T cells, mainly by promoting expression of the anti-apoptotic protein Bcl-2 (9-11). It is required for optimal T cell-dendritic cell interaction (6). IL-7 is expressed early in B cell development prior to the appearance of surface IgM (1, 5, 9). In mouse, IL-7 activation of IL-7 R alpha is critical for both T cell and B cell lineage development, while in humans, it is required for T cell but not for B cell development (4, 9, 12, 13). However, IL-7 functions in both mouse and human pro-B cells to suppress premature Ig light chain recombination during proliferative growth (14, 15).

  • References:
    1. Sasson, S.C. et al. (2006) Curr. Drug Targets 7:1571.
    2. Barata, J.T. et al. (2006) Exp. Hematol. 34:1133.
    3. Goodwin, R.G. et al. (1990) Proc. Natl. Acad. Sci. USA 86:302.
    4. Namen, A.E. et al. (1988) Nature 333:571.
    5. Shalapour, S. et al. (2012) PLoS ONE 7: e31939.
    6. Saini, M. et al. (2009) Blood 113:5793.
    7. Park, J.H. et al. (2004) Immunity 21:289.
    8. Vranjkovic, A. et al. (2007) Int. Immunol. 19:1329.
    9. Sudo, T. et al. (1993) Proc. Natl. Acad. Sci. 90:9125.
    10. Seddon, B. et al. (2003) Nat. Immunol. 4:680.
    11. Schluns, K.S. et al. (2000) Nat. Immunol. 5:426.
    12. Peschon, J.J. et al. (1994) J. Exp. Med. 180:1955.
    13. Pribyl, J.A. and T.W. LeBien (1996) Proc. Natl. Acad. Sci. 93:10348.
    14. Johnson, K. et al. (2012) J. Immunol. 188:6084.
    15. Nodland, S.E. et al. (2011) Blood 118:2116.
  • Long Name:
    Interleukin 7
  • Entrez Gene IDs:
    3574 (Human); 16196 (Mouse); 25647 (Rat)
  • Alternate Names:
    IL7; IL-7; IL-7interleukin-7; interleukin 7; Lymphopoietin-1; PBGF
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

54 Citations: Showing 1 - 10
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Applications
Sample Type
  1. IgH isotype-specific B cell receptor expression influences B cell fate
    Authors: P Tong, A Granato, T Zuo, N Chaudhary, A Zuiani, SS Han, R Donthula, A Shrestha, D Sen, JM Magee, MP Gallagher, CE van der Po, MC Carroll, DR Wesemann
    Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  2. The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice
    Authors: M Han, C Rajput, JY Hong, J Lei, JL Hinde, Q Wu, JK Bentley, MB Hershenson
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  3. Infection exposure promotes ETV6-RUNX1 precursor B cell leukemia via impaired H3K4 demethylases
    Authors: G Rodríguez-, J Hauer, A Martín-Lor, D Schäfer, C Bartenhage, I García-Ram, F Auer, I Gonzalez-H, L Ruiz-Roca, M Gombert, V Okpanyi, U Fischer, C Chen, M Dugas, S Bhatia, RM Linka, M Garcia-Suq, MV Rascón-Tri, A Garcia-San, O Blanco, MB Garcia-Cen, FJ Garcia-Cri, C Cobaleda, D Alonso-Lóp, J De Las Riv, M Müschen, C Vicente-Du, I Sánchez-Ga, A Borkhardt
    Cancer Res., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  4. The microRNA miR-31 inhibits CD8(+) T cell function in chronic viral infection
    Authors: HF Moffett, ANR Cartwright, HJ Kim, J Godec, J Pyrdol, T Äijö, GJ Martinez, A Rao, J Lu, TR Golub, H Cantor, AH Sharpe, CD Novina, KW Wucherpfen
    Nat. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  5. A Bach2-Cebp Gene Regulatory Network for the Commitment of Multipotent Hematopoietic Progenitors
    Authors: A Itoh-Nakad, M Matsumoto, H Kato, J Sasaki, Y Uehara, Y Sato, R Ebina-Shib, M Morooka, R Funayama, K Nakayama, K Ochiai, A Muto, K Igarashi
    Cell Rep, 2017;18(10):2401-2414.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  6. Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1
    Authors: S Shukla, MA Langley, J Singh, JM Edgar, M Mohtashami, JC Zúñiga-Pfl, PW Zandstra
    Nat. Methods, 2017;14(5):531-538.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  7. Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell Receptor Signaling
    Authors: MJ de Bruijn, J Rip, EK van der Pl, LW van Greuni, VT Ta, LP Kil, AW Langerak, GF Rimmelzwaa, W Ellmeier, RW Hendriks, OB Corneth
    J. Immunol, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  8. The non-canonical Wnt receptor Ryk regulates hematopoietic stem cell repopulation in part by controlling proliferation and apoptosis
    Cell Death Dis, 2016;7(11):e2479.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  9. Mannose-Capped Lipoarabinomannan from Mycobacterium tuberculosis Induces CD4+ T Cell Anergy via GRAIL.
    Authors: Sande O, Karim A, Li Q, Ding X, Harding C, Rojas R, Boom W
    J Immunol, 2016;196(2):691-702.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  10. SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells.
    Authors: Gerby B, Tremblay C, Tremblay M, Rojas-Sutterlin S, Herblot S, Hebert J, Sauvageau G, Lemieux S, Lecuyer E, Veiga D, Hoang T
    PLoS Genet, 2015;10(12):e1004768.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  11. An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development.
    Authors: Hao B, Naik A, Watanabe A, Tanaka H, Chen L, Richards H, Kondo M, Taniuchi I, Kohwi Y, Kohwi-Shigematsu T, Krangel M
    J Exp Med, 2015;212(5):809-24.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  12. IL-18 acts in synergy with IL-7 to promote ex vivo expansion of T lymphoid progenitor cells.
    Authors: Gandhapudi S, Tan C, Marino J, Taylor A, Pack C, Gaikwad J, Van De Wiele C, Wren J, Teague T
    J Immunol, 2015;194(8):3820-8.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  13. Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia.
    Authors: Lubeck B, Lapinski P, Oliver J, Ksionda O, Parada L, Zhu Y, Maillard I, Chiang M, Roose J, King P
    J Immunol, 2015;195(1):31-5.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  14. Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint.
    Authors: Tamehiro N, Oda H, Shirai M, Suzuki H
    PLoS ONE, 2015;10(6):e0131047.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  15. Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine.
    Authors: Bando J, Liang H, Locksley R
    Nat Immunol, 2015;16(2):153-60.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  16. The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.
    Authors: Smeets M, DeLuca E, Wall M, Quach J, Chalk A, Deans A, Heierhorst J, Purton L, Izon D, Walkley C
    J Clin Invest, 2014;124(8):3551-65.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  17. Aged mice are unable to mount an effective myeloid response to sepsis.
    Authors: Nacionales D, Gentile L, Vanzant E, Lopez M, Cuenca A, Cuenca A, Ungaro R, Li Y, Baslanti T, Bihorac A, Moore F, Baker H, Leeuwenburgh C, Moldawer L, Efron P
    J Immunol, 2014;192(2):612-22.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  18. Elimination of IL-10-inducing T-helper epitopes from an IGFBP-2 vaccine ensures potent antitumor activity.
    Authors: Cecil D, Holt G, Park K, Gad E, Rastetter L, Childs J, Higgins D, Disis M
    Cancer Res, 2014;74(10):2710-8.
    Species: Mouse
    Sample Type: Whole Cells
  19. Differential role of Th1 and Th2 cytokines in autotoxicity driven by CD19-specific second-generation chimeric antigen receptor T cells in a mouse model.
    Authors: Cheadle E, Sheard V, Rothwell D, Bridgeman J, Ashton G, Hanson V, Mansoor A, Hawkins R, Gilham D
    J Immunol, 2014;192(8):3654-65.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  20. Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma.
    Authors: Green M, Vicente-Duenas C, Romero-Camarero I, Long Liu C, Dai B, Gonzalez-Herrero I, Garcia-Ramirez I, Alonso-Escudero E, Iqbal J, Chan W, Campos-Sanchez E, Orfao A, Pintado B, Flores T, Blanco O, Jimenez R, Martinez-Climent J, Criado F, Cenador M, Zhao S, Natkunam Y, Lossos I, Majeti R, Melnick A, Cobaleda C, Alizadeh A, Sanchez-Garcia I
    Nat Commun, 2014;5(0):3904.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  21. A committed precursor to innate lymphoid cells.
    Authors: Constantinides, Michael, McDonald, Benjamin, Verhoef, Philip A, Bendelac, Albert
    Nature, 2014;508(7496):397-401.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  22. Ectopic TLX1 expression accelerates malignancies in mice deficient in DNA-PK.
    Authors: Krutikov K, Zheng Y, Chesney A, Huang X, Vaags A, Evdokimova V, Hough M, Chen E
    PLoS ONE, 2014;9(2):e89649.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  23. Id1 expression promotes T regulatory cell differentiation by facilitating TCR costimulation.
    Authors: Liu C, Wang H, Yu S, Jin R, Tang H, Liu Y, Ge Q, Sun X, Zhang Y
    J Immunol, 2014;193(2):663-72.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  24. The TCR ligand-inducible expression of CD73 marks gammadelta lineage commitment and a metastable intermediate in effector specification.
    Authors: Coffey F, Lee S, Buus T, Lauritsen J, Wong G, Joachims M, Thompson L, Zuniga-Pflucker J, Kappes D, Wiest D
    J Exp Med, 2014;211(2):329-43.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  25. The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells.
    Authors: Marcais A, Cherfils-Vicini J, Viant C, Degouve S, Viel S, Fenis A, Rabilloud J, Mayol K, Tavares A, Bienvenu J, Gangloff Y, Gilson E, Vivier E, Walzer T
    Nat Immunol, 2014;15(8):749-57.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  26. Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression.
    Authors: Wallington-Beddoe C, Powell J, Tong D, Pitson S, Bradstock K, Bendall L
    Cancer Res, 2014;74(10):2803-15.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  27. Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity.
    Authors: Berezhnoy, Alexey, Castro, Iris, Levay, Agata, Malek, Thomas R, Gilboa, Eli
    J Clin Invest, 2014;124(1):188-97.
    Species: Mouse
    Sample Type: Whole Cells
    Application: cell culture
  28. B-cell lymphopoiesis is regulated by cathepsin L.
    Authors: Badano M, Camicia G, Lombardi G, Maglioco A, Cabrera G, Costa H, Meiss R, Piazzon I, Nepomnaschy I
    PLoS ONE, 2013;8(4):e61347.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  29. A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.
    Authors: Olive V, Sabio E, Bennett M, De Jong C, Biton A, McGann J, Greaney S, Sodir N, Zhou A, Balakrishnan A, Foth M, Luftig M, Goga A, Speed T, Xuan Z, Evan G, Wan Y, Minella A, He L
    Elife, 2013;2(0):e00822.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  30. The inhibitory receptor BTLA controls gammadelta T cell homeostasis and inflammatory responses.
    Authors: Bekiaris V, Sedy J, Macauley M, Rhode-Kurnow A, Ware C
    Immunity, 2013;39(6):1082-94.
  31. A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells.
    Authors: Guo Z, Khattar M, Schroder P, Miyahara Y, Wang G, He X, Chen W, Stepkowski S
    J Immunol, 2013;190(7):3153-62.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  32. The BCL11A transcription factor directly activates RAG gene expression and V(D)J recombination.
    Authors: Lee, Baeck-se, Dekker, Joseph D, Lee, Bum-kyu, Iyer, Vishwana, Sleckman, Barry P, Shaffer, Arthur L, Ippolito, Gregory, Tucker, Philip W
    Mol Cell Biol, 2013;33(9):1768-81.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  33. Moesin controls clathrin-mediated S1PR1 internalization in T cells.
    Authors: Nomachi, Akira, Yoshinaga, Masanori, Liu, Jaron, Kanchanawong, Pakorn, Tohyama, Kiyoshi, Thumkeo, Dean, Watanabe, Takeshi, Narumiya, Shuh, Hirata, Takako
    PLoS ONE, 2013;8(12):e82590.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  34. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development.
    Authors: Venigalla, Ram K C, McGuire, Victoria, Clarke, Rosemary, Patterson-Kane, Janet C, Najafov, Ayaz, Toth, Rachel, McCarthy, Pierre C, Simeons, Frederic, Stojanovski, Laste, Arthur, J Simon
    EMBO J, 2013;32(7):1008-22.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  35. Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.
    Authors: Sneddon, Julie B, Borowiak, Malgorza, Melton, Douglas
    Nature, 2012;491(7426):765-8.
    Species: Human
    Sample Type: Whole Cells
    Application: Cell Culture Substrate
  36. Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing gammadelta cells.
    Authors: Michel M, Pang D, Haque S, Potocnik A, Pennington D, Hayday A
    Proc Natl Acad Sci U S A, 2012;109(43):17549-54.
    Species: Mouse
    Sample Type: In Vivo
    Application: Bioassay
  37. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012;109(25):9971-6.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  38. Plac8-dependent and inducible NO synthase-dependent mechanisms clear Chlamydia muridarum infections from the genital tract.
    Authors: Johnson RM, Kerr MS, Slaven JE
    J. Immunol., 2012;188(4):1896-904.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  39. Apoptotic programs are determined during lineage commitment of CD4+ T effectors: selective regulation of T effector-memory apoptosis by inducible nitric oxide synthase.
    Authors: Purushothaman D, Marcel N, Garg M, Venkataraman R, Sarin A
    J Immunol, 2012;190(1):97-105.
    Species: Mouse
    Sample Type: Whole Cells
    Application: cell culture
  40. Developmental heterogeneity in DNA packaging patterns influences T-cell activation and transmigration.
    Authors: Gupta S, Marcel N, Talwar S, Garg M, R I, Perumalsamy L, Sarin A, Shivashankar G
    PLoS ONE, 2012;7(9):e43718.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  41. IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs.
    Authors: Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H
    J. Immunol., 2011;188(3):1503-13.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  42. Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease.
    Authors: Liu X, Leung S, Wang C, Tan Z, Wang J, Guo TB, Fang L, Zhao Y, Wan B, Qin X, Lu L, Li R, Pan H, Song M, Liu A, Hong J, Lu H, Zhang JZ
    Nat. Med., 2010;16(2):191-7.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  43. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
    Authors: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
    J. Virol., 2010;84(24):12703-12.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  44. Thymic regulation of autoimmune disease by accelerated differentiation of Foxp3+ regulatory T cells through IL-7 signaling pathway.
    Authors: Chen X, Fang L, Song S, Guo TB, Liu A, Zhang JZ
    J. Immunol., 2009;183(10):6135-44.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  45. Osteoblastic regulation of B lymphopoiesis is mediated by Gs alpha-dependent signaling pathways.
    Authors: Wu JY, Purton LE, Rodda SJ, Chen M, Weinstein LS, McMahon AP, Scadden DT, Kronenberg HM
    Proc. Natl. Acad. Sci. U.S.A., 2008;105(44):16976-81.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  46. IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development.
    Authors: Vang KB, Yang J, Mahmud SA, Burchill MA, Vegoe AL, Farrar MA
    J. Immunol., 2008;181(5):3285-90.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  47. Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells.
    Authors: Zhu J, Garrett R, Jung Y, Zhang Y, Kim N, Wang J, Joe GJ, Hexner E, Choi Y, Taichman RS, Emerson SG
    Blood, 2007;109(9):3706-12.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  48. Role of CD30 in B/T segregation in the spleen.
    Authors: Bekiaris V, Withers D, Glanville SH, McConnell FM, Parnell SM, Kim MY, Gaspal FM, Jenkinson E, Sweet C, Anderson G, Lane PJ
    J. Immunol., 2007;179(11):7535-43.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  49. IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells.
    Authors: Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA
    J. Immunol., 2007;178(4):2018-27.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  50. Transforming growth factor-beta1 sensitivity is altered in Abl-Myc- and Raf-Myc-induced mouse pre-B-cell tumors.
    Authors: Letterio J, Rudikoff E, Voong N, Bauer SR
    Stem Cells, 2006;24(12):2611-7.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  51. Galectin-1 supports survival of naive T cells without promoting cell proliferation.
    Authors: Endharti AT, Zhou YW, Nakashima I, Suzuki H
    Eur. J. Immunol., 2005;35(1):86-97.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  52. Murine and human IL-7 activate STAT5 and induce proliferation of normal human pro-B cells.
    Authors: Johnson SE, Shah N, Panoskaltsis-Mortari A, Lebien TW
    J. Immunol., 2005;175(11):7325-31.
    Application: ELISA Standard
  53. A recombinant single-chain IL-7/HGFbeta hybrid cytokine induces juxtacrine interactions of the IL-7 and HGF (c-Met) receptors and stimulates the proliferation of CFU-S12, CLPs, and pre-pro-B cells.
    Authors: Lai L, Zeff RA, Goldschneider I
    Blood, 2005;107(5):1776-84.
  54. Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease.
    Authors: Alpdogan O, Schmaltz C, Muriglan SJ, Kappel BJ, Perales MA, Rotolo JA, Halm JA, Rich BE, van den Brink MR
    Blood, 2001;98(7):2256-65.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
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