Recombinant Mouse VSIG3 Fc Chimera (Catalog # 9367-VS)inhibits anti-CD3 antibody induced IL-17 secretion in human PBMC.The ED50 for this effect is 1-5 μg/mL.
VSIG3 (V-set and immunoglobulin domain containing 3) also known as IgSF11 (Immunoglobulin
superfamily member 11), is an approximately 50 kDa type I
transmembrane adhesion protein of the Ig superfamily. Mature
mouse VSIG3 consists of a 218 amino acid (aa) extracellular domain (ECD)
containing one V-type Ig-like domain and one Ig-like C2-type domain, a 21 aa transmembrane
domain, and a 167 aa cytoplasmic domain. Within the ECD, mouse VSIG3
shares 95% and 98% aa identity with human and rat VSIG3, respectively. VSIG3 is expressed on
epithelial and endothelial cells, neurons and glial cells, and platelets (1).
It localizes to epithelial tight junctions and mediates homophilic in trans
cell adhesion (1-3). VSIG3 also localizes to neuronal postsynaptic densities
where it recruits the GluA1 and GluA2 subunits of AMPA receptors and supports
excitatory synaptic transmission (4). In zebrafish, VSIG3 is expressed in
melanophores and their precursors and plays a role in the development and
patterning of pigment cells (5). VSIG-3 expression is elevated in colorectal
cancers and hepatocellular carcinomas as well as intestinal-type gastric
cancers. Suppression of VSIG-3 by siRNA retarded the growth of gastric cancer
cells, suggesting that VSIG-3 is a good candidate for gastric cancer
Raschperger, E. et al. (2004) J. Biol. Chem. 279:796.
Katoh, M. and M. Katoh (2003) Int. J. Oncol. 23:525.
Harada, H. et al. (2005) J. Cell. Physiol. 204:919.
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