RETRA hydrochloride
Chemical Name: 2-[(4,5-Dihydro-2-thiazolyl)thio]-1-(3,4-dihydroxyphenyl)ethanone hydrochloride
Purity: ≥99%
Biological Activity
Antitumor agent. Inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and in vivo (IC50 = 4 μM). Transcriptionally activates expression of p53-responsive genes and induces activation of effector caspases 3 and 7.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway.
Kravchenko et al.
Proc.Natl.Acad.Sci.USA, 2008;105:6302
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