Antitumor agent. Inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro
and in vivo
= 4 μ
M). Transcriptionally activates expression of p53-responsive genes and induces activation of effector caspases 3 and 7.
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All Tocris products are intended for laboratory research use only.
Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway.
Kravchenko et al.