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RETRA hydrochloride

3214 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3214/10
3214/50
RETRA hydrochloride | CAS No. 1173023-52-3 | Additional p53-related Compounds
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Description: Antitumor agent; suppresses mutant p53-bearing cancer cells

Chemical Name: 2-[(4,5-Dihydro-2-thiazolyl)thio]-1-(3,4-dihydroxyphenyl)ethanone hydrochloride

Purity: ≥99%

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Biological Activity

RETRA hydrochloride is an antitumor agent. Inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and in vivo (IC50 = 4 μM). Transcriptionally activates expression of p53-responsive genes and induces activation of effector caspases 3 and 7.

Technical Data

M.Wt:
305.8
Formula:
C11N11NO3S2.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1173023-52-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway.
    Kravchenko et al.
    Proc.Natl.Acad.Sci.USA, 2008;105:6302

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