RS 1

Catalog # Availability Size / Price Qty
5810/10
5810/50
Cat.No. 5810 - RS 1 | C20H16Br2N2O3S | CAS No. 312756-74-4
1 Image
Description: High affinity RAD51 activator; also CRISPR enhancer

Chemical Name: 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide

Purity: ≥98%

Product Details
Reviews

Biological Activity

High affinity RAD51 activator (Kd range = 48-107 nM, value depends on cofactors present). Enhances homologous recombination activity of hRAD51. Enhances homology-directed repair ~2 to 5-fold and increases CRISPR-mediated knock-in efficiencies in vitro and in vivo.

Technical Data

M.Wt:
524.23
Formula:
C20H16Br2N2O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
312756-74-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency.
    Song et al.
    Nat.Commun., 2016;7:10548
  2. A chemical compound that stimulates the human homologous recombination protein RAD51.
    Jayathilaka et al.
    Proc.Natl.Acad.Sci.U.S.A., 2008;105:15848

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

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