Catalog Number: 5810
Chemical Name: 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide
Biological Activity
High affinity RAD51 activator (Kd range = 48-107 nM, value depends on cofactors present). Enhances homologous recombination activity of hRAD51. Enhances homology-directed repair ~2 to 5-fold and increases CRISPR-mediated knock-in efficiencies in vitro and in vivo.
Technical Data
  • M.Wt:
    524.23
  • Formula:
    C20H16Br2N2O3S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    312756-74-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency.
    Song et al.
    Nat.Commun., 2016;7:10548
  2. A chemical compound that stimulates the human homologous recombination protein RAD51.
    Jayathilaka et al.
    Proc.Natl.Acad.Sci.U.S.A., 2008;105:15848

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