RS 504393

  ( 14 citations )    
Product Datasheet
Catalog Number:2517
Chemical Name:6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one
Product Details
Citations (14)
Supplemental Products
Reviews
Biological Activity
Extremely selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.
Technical Data
  • M.Wt:
    417.5
  • Formula:
    C25H27N3O3
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    300816-15-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for RS 504393 include:

14 Citations: Showing 1 - 10
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  1. Macrophages orchestrate breast cancer early dissemination and metastasis.
    Authors: Linde
    Nat Commun  2018;9(1):21
  2. The RS504393 Influences the Level of Nociceptive Factors and Enhances Opioid Analgesic Potency in Neuropathic Rats.
    Authors: Kwiatkowski Et al.
    J Neuroimmune Pharmacol  2017;
  3. Inhibiting the mobilization of Ly6C(high) monocytes after acute myocardial infarction enhances the efficiency of mesenchymal stromal cell transplantation and curbs myocardial remodeling.
    Authors: Lu Et al.
    J Neurosci  2015;7:587
  4. Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity.
    Authors: Matsubara Et al.
    Cancer Res  2015;35:2452
  5. Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.
    Authors: Lourenco Et al.
    J Immunol  2015;194:3463
  6. CoREST1 Promotes Tumor Formation and Tumor Stroma Interactions in a Mouse Model of Breast Cancer.
    Authors: Mazumdar Et al.
    PLoS One  2015;10:e0121281
  7. Functional Interaction between Angiotensin II Receptor Type 1 and Chemokine (C-C Motif) Receptor 2 with Implications for Chronic Kidney Disease.
    Authors: Ayoub Et al.
    PLoS One  2015;10:e0119803
  8. IL-33-induced hematopoietic stem and progenitor cell mobilization depends upon CCR2.
    Authors: Kim Et al.
    J Immunol  2014;193:3792
  9. Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis.
    Authors: Arendt Et al.
    J Biol Chem  2013;73:6080
  10. Expression and function of CCL2/CCR2 in rat micturition reflexes and somatic sensitivity with urinary bladder inflammation.
    Authors: Arms Et al.
    Am J Physiol Renal Physiol  2013;305:F111
  11. Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain.
    Authors: Zhang Et al.
    J Neuroinflammation  2012;9:136
  12. CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis.
    Authors: Miller Et al.
    Proc Natl Acad Sci U S A  2012;109:20602
  13. Endothelin-1 increases collagen accumulation in renal mesangial cells by stimulating a chemokine and cytokine autocrine signaling loop.
    Authors: Simonson and Ismail-Beigi
    Br J Pharmacol  2011;286:11003
  14. Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy.
    Authors: Yang Et al.
    Diabetologia  2009;52:972
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