Extremely selective CCR2 chemokine receptor antagonist (IC50
values are 98 nM and > 100 μ
M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC50
= 330 nM) and ischemia-reperfusion injury in kidneys.
Soluble to 10 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists.
Mirzadegan et al.
CCR2 signaling contributes to ischemia-reperfusion injury in kidney.
Furuichi et al.
Blockade of CCR2 ameliorates progressive fibrosis in kidney.
Kitagawa et al.
The citations listed below are publications that use Tocris products. Selected citations for RS 504393 include:
Showing Results 1 - 10 of 12