RS 504393

Tocris Bioscience | Catalog # 2517

Highly selective CCR2 chemokine receptor antagonist
Tocris Bioscience

Key Product Details

Description

Highly selective CCR2 chemokine receptor antagonist
View all Chemokine Receptor Antagonists »

Product Description

RS 504393 is an extremely selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.

Product Specifications for RS 504393

Molecular Weight

417.50

Formula

C25H27N3O3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one

CAS Number

300816-15-3

PubChem ID

9953769

InChI Key

ODNICNWASXKNNQ-UHFFFAOYSA-N

SMILES

CC1=C(CCN2CCC3(CC2)OC(=O)NC2=C3C=C(C)C=C2)N=C(O1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.17 10

Preparing Stock Solutions for RS 504393

The following data is based on the product molecular weight 417.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.95 mL 119.76 mL 239.52 mL
0.5 mM 4.79 mL 23.95 mL 47.90 mL
1 mM 2.40 mL 11.98 mL 23.95 mL
5 mM 0.48 mL 2.40 mL 4.79 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 129 publications citing the usage of this product.

Product Documents for RS 504393

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for RS 504393

For research use only

Customer Reviews for RS 504393 (1)

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  • Used for Migration assays
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: A549 or MDAMB231
    Verified Customer | Posted 07/01/2020
    We ordered this product, combining with another inhibitor, to confirm the migration.To confirm that tested product induces migration, we also screen all MAPK inhibitors and MIF receptor antagonists
    Receptor antagonists (SB225002: for CXCR2, AMD3465: for CXCR4, RS504393: for CCR2 and Maraviroc: for CCR5) at 10 μM
    RS 504393 2517

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