Salmeterol
Chemical Name: 4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol
Purity: ≥99%
Biological Activity
Potent and selective β2-adrenoceptor agonist (EC50 = 5.3 nM); bronchodilator. Unlike other β2 agonists, binds to exo-site domain of β2 receptors, producing a slow onset of action and prolonged activation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Role of AKAP79/150 protein in beta1-adrenergic receptor trafficking and signaling in mammalian cells.
Li X, Nooh M, Bahouth S
J Biol Chem, 2013;288(47):33797-812. -
Stable activation and desensitization of β2-adrenergic receptor stimulation of adenylyl cyclase by salmeterol: evidence for quasi-irreversible binding to an exosite.
Clark et al.
Mol.Pharmacol., 1996;49:182 -
Correlation of cyclic AMP accumulation and relaxant actions of salme. and salbutamol in bovine tracheal smooth muscle.
Ellis et al.
Br.J.Pharmacol., 1995;116:2510 -
The pharmacology of salme.
Johnson et al.
Life Sci., 1993;52:2131
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