SANT-2

Catalog # Availability Size / Price Qty
3617/10
3617/50
SANT-2 | CAS No. 329196-48-7 | Hedgehog Signaling Inhibitors
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Description: Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity

Chemical Name: N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

Inhibitor of Sonic hedgehog (Shh) signaling; antagonizes smoothened receptor activity (KD = 12 nM). Displays allosteric binding characteristics similar to SANT-1 (Cat. No. 1974). Displaces smo-[3H]SAG-1.3 and -[3H]Cyclopamine binding (Ki values are 7.8 nM and 8.4 nM respectively).

Technical Data

M.Wt:
479.96
Formula:
C26H26ClN3O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
329196-48-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Evidence for allosteric interactions of antagonist binding to the smoothened receptor.
    Rominger et al.
    J.Pharmacol.Exp.Ther., 2009;329:995
  2. Small molecule modulation of smoothened activity.
    Chen et al.
    Proc.Natl.Acad.Sci., 2002;99:14071

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Citation for SANT-2

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