Chemical Name: N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
Biological ActivityInhibitor of Sonic hedgehog (Shh) signaling; antagonizes smoothened receptor activity (KD = 12 nM). Displays allosteric binding characteristics similar to SANT-1 (Cat. No. 1974). Displaces smo-[3H]SAG-1.3 and -[3H]Cyclopamine binding (Ki values are 7.8 nM and 8.4 nM respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Evidence for allosteric interactions of antagonist binding to the smoothened receptor.
Rominger et al.
Small molecule modulation of smoothened activity.
Chen et al.
Citation for SANT-2
The citations listed below are publications that use Tocris products. Selected citations for SANT-2 include:
1 Citation: Showing 1 - 1
Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein.
Authors: Strating Et al.
Cell Rep 2015;10:600
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VersaClone cDNA Plasmids
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