Chemical Name: N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
Biological ActivitySANT-2 is an inhibitor of Sonic hedgehog (Shh) signaling; antagonizes smoothened receptor activity (KD = 12 nM). Displays allosteric binding characteristics similar to SANT-1 (Cat. No. 1974). Displaces smo-[3H]SAG-1.3 and -[3H]Cyclopamine binding (Ki values are 7.8 nM and 8.4 nM respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Evidence for allosteric interactions of antagonist binding to the smoothened receptor.
Rominger et al.
Small molecule modulation of smoothened activity.
Chen et al.
Citation for SANT-2
The citations listed below are publications that use Tocris products. Selected citations for SANT-2 include:
1 Citation: Showing 1 - 1
Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein.
Authors: Strating Et al.
Cell Rep 2015;10:600
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for SANT-2
There are currently no reviews for this product. Be the first to review SANT-2 and earn rewards!
Have you used SANT-2?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image