Inhibitor of Sonic hedgehog (Shh) signaling; antagonizes smoothened receptor activity (KD
= 12 nM). Displays allosteric binding characteristics similar to SANT-1
(Cat. No. 1974). Displaces smo-[3
H]SAG-1.3 and -[3
H]Cyclopamine binding (Ki
values are 7.8 nM and 8.4 nM respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Evidence for allosteric interactions of antagonist binding to the smoothened receptor.
Rominger et al.
Small molecule modulation of smoothened activity.
Chen et al.