SB 269970 hydrochloride
Chemical Name: (2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine hydrochloride
Biological ActivitySB 269970 hydrochloride is a potent and selective 5-HT7 receptor antagonist (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B and < 6.0 for 5-HT1A, 5-HT1D, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT4 and 5-HT6 receptors respectively). Brain penetrant in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterization of SB-269970-A, a selective 5-HT7 receptor antagonist.
Hagan et al.
DR4004, a putative 5-HT7 receptor antagonist, also has functional activity at the DA receptor.
Kogan et al.
A novel, potent, and selective 5-HT7 antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)-ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)
Lovell et al.
Citations for SB 269970 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for SB 269970 hydrochloride include:
20 Citations: Showing 1 - 10
Modulation of Gut Microbiota Composition by Serotonin Signaling Influences Intestinal Immune Response and Susceptibility to Colitis.
Authors: Kwon Et al.
Cell Mol Gastroenterol Hepatol 2019;7:709
Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice.
Authors: Nguyen Et al.
Korean J Physiol Pharmacol 2019;23:271
Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron.
Authors: Yin Et al.
Cereb Cortex 2017;27:509
Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix
Cell Rep 2017;19:1767
Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons
J Neurochem 2017;141:647
Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling.
Authors: Gautam Et al.
Mol Cancer 2016;15:75
Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics.
Authors: Speranza Et al.
J Biomed Sci 2015;9:62
5-HT is a potent relaxant in rat superior mesenteric veins.
Authors: Watts Et al.
J Immunol 2015;3:e00103
5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts.
Authors: Chien and Su
Pharmacol Res Perspect 2015;22:42
Effect of peripheral 5-HT on glucose and lipid metabolism in wether sheep.
Authors: Watanabe Et al.
PLoS One 2014;9:e88058
Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice.
Authors: Corcoran Et al.
Front Behav Neurosci 2014;34:51
Effects of the selective 5-HT7 receptor antagonist SB-269970 and amisulpride on KA-induced schizophrenia-like deficits in rats.
Authors: Nikiforuk Et al.
PLoS One 2013;8:e66695
Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation.
Authors: Kim Et al.
J Biol Chem 2013;190:4795
Expression of serotonin receptors in human hepatocellular cancer.
Authors: Soll Et al.
Clin Cancer Res 2012;18:5902
Pharmacological blockade of serotonin 5-HT7 receptor reverses working memory deficits in rats by normalizing cortical glutamate neurotransmission.
Authors: Bonaventure Et al.
PLoS One 2011;6:e20210
5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.
Authors: Müller Et al.
PLoS One 2009;4:e6453
Serotonin targets inhibitory synapses to induce modulation of network functions.
Authors: Manzke Et al.
Philos Trans R Soc Lond B Biol Sci 2009;364:2589
Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex.
Authors: Huang Et al.
Brown adipose tissue sympathetic nerve activity is potentiated by activation of 5-hydroxytryptamine (5-HT)1A/5-HT7 receptors in the rat spinal cord.
Authors: Madden and Morrison
Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs.
Authors: Hampson Et al.
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