SB 269970 hydrochloride

  ( 17 citations )    
Product Datasheet
Catalog Number:1612
Chemical Name:(2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine hydrochloride
Product Details
Citations (17)
Supplemental Products
Reviews
Biological Activity
Potent and selective 5-HT 7 receptor antagonist (pK i values are 8.9, 7.2 and 6.0 for 5-HT 7A 5-HT 5A and 5-HT 1B and < 6.0 for 5-HT 1A 5-HT 1D 5-HT 1E 5-HT 1F 5-HT 2A 5-HT 2B 5-HT 2C 5-HT 4 and 5-HT 6 receptors respectively). Brain penetrant in vivo.
Technical Data
  • M.Wt:
    388.95
  • Formula:
    C18H28N2O3S.HCl
  • Solubility:
    Soluble to 20 mM in water and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    261901-57-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 269970 hydrochloride include:

17 Citations: Showing 1 - 10
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  1. Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix
    Authors: Bijata
    Cell Rep  2017;19:1767
  2. Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons
    Authors: Speranza
    J Neurochem  2017;141:647
  3. Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling.
    Authors: Gautam Et al.
    Mol Cancer  2016;15:75
  4. Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics.
    Authors: Speranza Et al.
    J Biomed Sci  2015;9:62
  5. 5-HT is a potent relaxant in rat superior mesenteric veins.
    Authors: Watts Et al.
    J Immunol  2015;3:e00103
  6. 5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts.
    Authors: Chien and Su
    Pharmacol Res Perspect  2015;22:42
  7. Effect of peripheral 5-HT on glucose and lipid metabolism in wether sheep.
    Authors: Watanabe Et al.
    PLoS One  2014;9:e88058
  8. Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice.
    Authors: Corcoran Et al.
    Front Behav Neurosci  2014;34:51
  9. Effects of the selective 5-HT7 receptor antagonist SB-269970 and amisulpride on ketamine-induced schizophrenia-like deficits in rats.
    Authors: Nikiforuk Et al.
    PLoS One  2013;8:e66695
  10. Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation.
    Authors: Kim Et al.
    J Biol Chem  2013;190:4795
  11. Expression of serotonin receptors in human hepatocellular cancer.
    Authors: Soll Et al.
    Clin Cancer Res  2012;18:5902
  12. Pharmacological blockade of serotonin 5-HT7 receptor reverses working memory deficits in rats by normalizing cortical glutamate neurotransmission.
    Authors: Bonaventure Et al.
    PLoS One  2011;6:e20210
  13. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.
    Authors: M&#252;ller Et al.
    PLoS One  2009;4:e6453
  14. Serotonin targets inhibitory synapses to induce modulation of network functions.
    Authors: Manzke Et al.
    Philos Trans R Soc Lond B Biol Sci  2009;364:2589
  15. Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex.
    Authors: Huang Et al.
    Neuropsychopharmacology  2009;34:1979
  16. Brown adipose tissue sympathetic nerve activity is potentiated by activation of 5-hydroxytryptamine (5-HT)1A/5-HT7 receptors in the rat spinal cord.
    Authors: Madden and Morrison
    Neuropharmacology  2008;54:487
  17. Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs.
    Authors: Hampson Et al.
    Diabetologia  2007;50:1743
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VersaClone cDNA Plasmids
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Human 5-HT7 (NP_000863) VersaClone cDNA

RDC0251
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Human 5-HT7 (NP_062874) VersaClone cDNA

RDC0252
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