Chemical Name:(2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine hydrochloride
Biological Activity Potent and selective 5-HT 7 receptor antagonist (pK i values are 8.9, 7.2 and 6.0 for 5-HT 7A 5-HT 5A and 5-HT 1B and < 6.0 for 5-HT 1A 5-HT 1D 5-HT 1E 5-HT 1F 5-HT 2A 5-HT 2B 5-HT 2C 5-HT 4 and 5-HT 6 receptors respectively). Brain penetrant in vivo.
Soluble to 20 mM in water and to 100 mM in DMSO
Store at +4°C
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