SB 269970 hydrochloride

Tocris Bioscience | Catalog # 1612

Potent and selective 5-HT7 antagonist; brain penetrant
Tocris Bioscience

Key Product Details

Description

Potent and selective 5-HT7 antagonist; brain penetrant
View all 5-HT7 Receptor Antagonists »

Product Description

SB 269970 hydrochloride is a potent and selective 5-HT7 receptor antagonist (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B and < 6.0 for 5-HT1A, 5-HT1D, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT4 and 5-HT6 receptors respectively). Brain penetrant in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Product Specifications for SB 269970 hydrochloride

Molecular Weight

388.95

Formula

C18H28N2O3S.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine hydrochloride

CAS Number

261901-57-9

PubChem ID

11957684

InChI Key

XQCJOYZLWFNDIO-PKLMIRHRSA-N

SMILES

OC1=CC(S(N2[C@@H](CCN3CCC(C)CC3)CCC2)(=O)=O)=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 7.78 20
DMSO 38.89 100

Preparing Stock Solutions for SB 269970 hydrochloride

The following data is based on the product molecular weight 388.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.86 mL 25.71 mL
5 mM 0.51 mL 2.57 mL 5.14 mL
10 mM 0.26 mL 1.29 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 32 publications citing the usage of this product.

Product Documents for SB 269970 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SB 269970 hydrochloride

For research use only

Citations for SB 269970 hydrochloride

Customer Reviews for SB 269970 hydrochloride (1)

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  • 5-HT has a potential for relaxant
    Name: Anonymous
    Species: Rat
    Assay Type: In Vivo
    Verified Customer | Posted 02/18/2020
    1nM (As 5-HT7 receptor antagonists) SB 269970
    SB 269970 hydrochloride 1612

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