Chemical Name: 2-[2-[(6-Methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino]ethoxy]ethanol
Biological ActivitySCH 51344 is a potent MTH1 inhibitor (Kd = 49 nM). Inhibits Ras-induced malignant transformation and increases α-actin promoter-driven CAT activity in Ras-transformed cells. Has no effect on Ras-induced ERK and JNK activation. Inhibits Ras-induced membrane ruffling in REF-52 fibroblasts and blocks anchorage-independent growth of Ras-transformed tumor cell lines. Also induces DNA damage in SW480 colon cancer cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.
Huber KV, Salah E, Radic B et al.
SCH 51344-induced reversal of RAS-transformation is accompanied by the specific inhibition of the RAS and RAC-dependent cell morphology pathway.
Walsh et al.
SCH 51344, an inhibitor of RAS/RAC-mediated cell morphology pathway.
Kumar et al.
Citation for SCH 51344
The citations listed below are publications that use Tocris products. Selected citations for SCH 51344 include:
1 Citation: Showing 1 - 1
1H-Pyrazolo[3,4-b]quinolines: Synthesis and Properties over 100 Years of Research.
Authors: Andrzej Et al.
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