Catalog Number: 1410
Chemical Name: (4bS,8R,8aS,14bR)-5,6,7,8,14,14b-Hexahydro-7-(2-methyl-2-propenyl)-4,8-methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9H)-diol hydrochloride
Biological Activity
Potent and highly selective non-peptide δ receptor antagonist (Ki values are 4.7, 3800 and 7900 nM for δ, κ and μ receptors respectively). More selective than naltrindole (Cat. No. 0740). Also inhibits Dengue virus replication.
Technical Data
  • M.Wt:
    450.96
  • Formula:
    C26H26N2O3.HCl
  • Solubility:
    Soluble to 10 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    342884-71-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7:2 ',3 '-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy.
    McLamore et al.
    J.Med.Chem., 2001;44:1471
  2. RIG-I-like receptor triggering by Dengue virus drives dendritic cell immune activation and TH1 differentiation.
    Sprokholt et al.
    J.Immunol., 2017;
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SDM25N hydrochloride include:

3 Citations: Showing 1 - 3
Filter your results:

  1. RIG-I-like receptor triggering by Dengue virus drives dendritic cell immune activation and TH1 differentiation.
    Authors: Sprokholt Et al.
    J.Immunol. 2017;198:4764
  2. Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking.
    Authors: Ong Et al.
    Br J Pharmacol 2015;172:615
  3. Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication.
    Authors: van Cleef Et al.
    Antiviral Res. 2013;99:165

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