SH3BP1 Antibody

Name: SH3BP1 Antibody
Brand: Novus Biologicals
SKU: NB100-1398
Price: 399 USD
Availability: InStock

Novus Biologicals | Catalog # NB100-1398

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

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Product Specifications

Immunogen

Peptide with sequence C-PQPRPRSLASETN corresponding to C-Terminus according to NP_061830.3.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for SH3BP1 Antibody

Western Blot: SH3BP1 Antibody [NB100-1398]

Western Blot: SH3BP1 Antibody [NB100-1398] - SH3BP1 in Human Brain lysate using NB100-1398 at 1 ug/ ml.

Immunohistochemistry-Paraffin: SH3BP1 Antibody [NB100-1398]

Immunohistochemistry-Paraffin: SH3BP1 Antibody [NB100-1398] - NB100-1398 (0.3ug/ml) staining of paraffin embedded Human Kidnay. Cytoplasmic staining of lymphocytes A) in the interstitial parenchyma of the kidney. B) in a glomerulus of the kidney. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining.

Applications for SH3BP1 Antibody

Application

Recommended Usage

Immunohistochemistry

0.3 ug/ml

Immunohistochemistry-Paraffin

1:10 - 1:500

Peptide ELISA

Detection limit 1:16000

Western Blot

1 - 3 ug/ml

Application Notes

ICC successful usage in Caco-2 cells is reported in scientific literature (Elbediwy et al, J.Biol. Chem, 2012). WB: Approx. 70 kDa band observed in human lung and kidney lysates (calculated MW of 75.7 kDa band according to NP_061830.3). IHC-P: Human kidney stains the cytoplasm of lymphoid cells in the interstitial parenchyma and of lymphocytes in a glomerulus.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: SH3BP1

Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to c-Abl proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac (By similarity).

Alternate Names

3BP-1, ARHGAP43, SH3 domain binding protein 1, SH3 domain-binding protein 1, SH3-domain binding protein 1

Entrez Gene IDs

23616 (Human)

Gene Symbol

SH3BP1

UniProt

NP_061830. (Human)

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Product Documents for SH3BP1 Antibody

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Certificate of Analysis

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Product Specific Notices for SH3BP1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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