SIB 1757 (CAS 31993-01-8): R&D Systems
Catalog Number: 1215
Chemical Name: 6-Methyl-2-(phenylazo)-3-pyridinol
Biological Activity
A highly selective antagonist for the mGlu5 metabotropic glutamate receptor subtype; displays an IC50 value of 0.4 μM at hmGlu5 compared with > 30 μM at hmGlu1b, hmGlu2, hmGlu4, hmGlu6, hmGlu7 and hmGlu8.
Technical Data
  • M.Wt:
    213.24
  • Formula:
    C12H11N3O
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    31993-01-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5.
    Varney et al.
    J.Pharmacol.Exp.Ther., 1999;290:170
  2. Characterisation of SIB-1757 and SIB-1893: highly selective antagonists at metabotropic glutamate receptor subtype 5.
    Varney et al.
    Br.J.Pharmacol., 1999;126:248P
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SIB 1757 include:

1 Citations: Showing 1 - 1

  1. Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist.
    Authors: El-Kouhen Et al.
    Br J Pharmacol 2006;149:761

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