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SIB 1757

Catalog #: 1215
3 Citations Datasheet / COA / SDS

Discontinued Product

1215 has been discontinued.
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SIB 1757 | CAS No. 31993-01-8 | Group I mGluR Antagonists
1 Image
Description: Highly selective mGlu5 antagonist

Chemical Name: 6-Methyl-2-(phenylazo)-3-pyridinol

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SIB 1757 is a highly selective antagonist for the mGlu5 metabotropic glutamate receptor subtype; displays an IC50 value of 0.4 μM at hmGlu5 compared with > 30 μM at hmGlu1b, hmGlu2, hmGlu4, hmGlu6, hmGlu7 and hmGlu8.

Technical Data

M.Wt:
213.24
Formula:
C12H11N3O
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at RT
CAS No:
31993-01-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Characterisation of SIB-1757 and SIB-1893: highly selective antagonists at metabotropic glutamate receptor subtype 5.
    Varney et al.
    Br.J.Pharmacol., 1999;126:248P
  3. SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5.
    Varney et al.
    J.Pharmacol.Exp.Ther., 1999;290:170

Product Datasheets

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Citations for SIB 1757

The citations listed below are publications that use Tocris products. Selected citations for SIB 1757 include:

3 Citations: Showing 1 - 3

  1. Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region.
    Authors: Zhao Et al.
    iScience  2018;6:138
  2. Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS.
    Authors: Koeglsperger Et al.
    Glia  2013;61:985
  3. Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist.
    Authors: El-Kouhen Et al.
    Br J Pharmacol  2006;149:761

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