SJ 172550

Catalog # Availability Size / Price Qty
3929/10
3929/50
p53 Activators Small Molecule
1 Image
Description: MDMX inhibitor. Disrupts MDMX-p53 interaction

Chemical Name: 2-[2-Chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]acetic acid methyl ester

Purity: ≥99%

Product Details
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Biological Activity

MDMX inhibitor. Reversibly binds MDMX (EC50 = 2.3 μM). Inhibits the MDMX-p53 interaction in cultured retinoblastoma cells; frees p53 to induce apoptosis.

Technical Data

M.Wt:
428.87
Formula:
C22H21ClN2O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
431979-47-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification and characterization of the first small molecule inhibitor of MDMX.
    Reed et al.
    J.Biol.Chem., 2010;285:10786

Product Datasheets

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