Catalog Number: 0391
Alternate Names: α-NAAG
Chemical Name: N-Acetyl-L-aspartyl-L-glutamic acid
Biological Activity
The most abundant peptide neurotransmitter in the mammalian CNS. A weak activator of NMDA receptors, and a highly selective agonist for mGlu3 receptors. Neuroprotective under non-hydrolysing conditions in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. N-Acetylated α-linked acidic dipeptidase converts N-acetylaspartylglutamate from a neuroprotectant to a neurotoxin.
    Thomas et al.
    J.Pharmacol.Exp.Ther., 2000;295:16
  2. N-Acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells.
    Wroblewska et al.
    J.Neurochem., 1997;69:174
  3. N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system.
    Neale et al.
    J.Neurochem., 2000;75:443

The citations listed below are publications that use Tocris products. Selected citations for Spaglumic acid include:

Showing Results 1 - 1 of 1

  1. The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes.
    Authors: Kolodziejczyk Et al.
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