Catalog Number: 0391
Alternate Names: α-NAAG
Chemical Name: N-Acetyl-L-aspartyl-L-glutamic acid
Biological Activity
The most abundant peptide neurotransmitter in the mammalian CNS. A weak activator of NMDA receptors, and a highly selective agonist for mGlu3 receptors. Neuroprotective under non-hydrolysing conditions in vivo.
Technical Data
  • M.Wt:
    304.26
  • Formula:
    C11H16N2O8
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >96%
  • Storage:
    Store at -20°C
  • CAS No:
    3106-85-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. N-Acetylated α-linked acidic dipeptidase converts N-acetylaspartylglutamate from a neuroprotectant to a neurotoxin.
    Thomas et al.
    J.Pharmacol.Exp.Ther., 2000;295:16
  2. N-Acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells.
    Wroblewska et al.
    J.Neurochem., 1997;69:174
  3. N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system.
    Neale et al.
    J.Neurochem., 2000;75:443
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Spaglumic acid include:

2 Citations: Showing 1 - 2
Filter your results:

  1. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
    Authors: Scholler
    Nat Chem Biol 2017;13(4):372
  2. The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes.
    Authors: Kolodziejczyk Et al.
    Brain 2009;132:1496

Have you used Spaglumic acid?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information