SR-AI/MSR Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-88125

Novus Biologicals
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all SR-AI/MSR Primary Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: KWETKNCSVSSTNANDITQSLTGKGNDSEEEMRFQEVFMEHMSNMEKRIQHILDMEANLMDTEHFQNFSMTTDQRFNDILLQLSTLFSSVQGHGNAIDEISKSLISLNTTLLDLQLNIENL

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SR-AI/MSR Antibody - BSA Free

Immunohistochemistry-Paraffin: SR-AI/MSR Antibody [NBP1-88125]

Immunohistochemistry-Paraffin: SR-AI/MSR Antibody [NBP1-88125]

Immunohistochemistry-Paraffin: SR-AI/MSR Antibody [NBP1-88125] - Staining in human lung and cerebral cortex tissues.. Corresponding MSR1 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: SR-AI/MSR Antibody [NBP1-88125]

Immunohistochemistry-Paraffin: SR-AI/MSR Antibody [NBP1-88125]

Immunohistochemistry-Paraffin: SR-AI/MSR Antibody [NBP1-88125] - Staining of human lung shows strong cytoplasmic positivity in macrophages.
Immunohistochemistry-Paraffin: SR-AI/MSR Antibody [NBP1-88125]

Immunohistochemistry-Paraffin: SR-AI/MSR Antibody [NBP1-88125]

Immunohistochemistry-Paraffin: SR-AI/MSR Antibody [NBP1-88125] - Staining of human cerebral cortex shows no positivity in neurons as expected.
Immunohistochemistry-Paraffin: SR-AI/MSR Antibody [NBP1-88125]

Immunohistochemistry-Paraffin: SR-AI/MSR Antibody [NBP1-88125]

Immunohistochemistry-Paraffin: SR-AI/MSR Antibody [NBP1-88125] - Staining of human liver shows strong cytoplasmic positivity in Kupffer cells.
Immunohistochemistry-Paraffin: SR-AI/MSR Antibody [NBP1-88125]

Immunohistochemistry-Paraffin: SR-AI/MSR Antibody [NBP1-88125]

Immunohistochemistry-Paraffin: SR-AI/MSR Antibody [NBP1-88125] - Staining of human bone marrow shows strong cytoplasmic positivity in hematopoietic cells.
Immunohistochemistry-Paraffin: SR-AI/MSR Antibody [NBP1-88125]

Immunohistochemistry-Paraffin: SR-AI/MSR Antibody [NBP1-88125]

Immunohistochemistry-Paraffin: SR-AI/MSR Antibody [NBP1-88125] - Staining of human spleen shows moderate cytoplasmic positivity in cells in red pulp.
SR-AI/MSR Antibody - BSA Free Western Blot: SR-AI/MSR Antibody - BSA Free [NBP1-88125]

Western Blot: SR-AI/MSR Antibody - BSA Free [NBP1-88125]

Analysis in control (vector only transfected HEK293T lysate) and mSR1 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells).

Applications for SR-AI/MSR Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000 - 1:2500

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SR-AI/MSR

Macrophage scavenger receptors (MSR) are membrane glycoproteins that mediate the recognition and uptake of a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of MSR is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Abeta deposition in Alzheimer's disease (AD).

In cell cultures, macrophage scavenger receptor has been shown to mediate adhesion of macrophages and other cell lines to tissue culture plastic. MSR1 antibodies are useful for research on atherosclerosis, Alzheimer's disease, and host defense.

Long Name

Macrophage Scavenger Receptor Types I and II

Alternate Names

CD204, MSR1, SCARA1, SRAI

Entrez Gene IDs

4481 (Human)

Gene Symbol

MSR1

UniProt

P21757

Additional SR-AI/MSR Products

Product Documents for SR-AI/MSR Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for SR-AI/MSR Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for SR-AI/MSR Antibody - BSA Free

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Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs

No product specific FAQs exist for this product.

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Associated Pathways

A-beta Pathways: Uptake & Degradation
A-beta Pathways: Uptake & Degradation Thumbnail