Chemical Name: 1-[(2R,5S)-2,5-Dihydro-5-(hydroxymethyl)-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
Biological ActivityNucleoside analog; antiviral that inhibits HIV replication in vitro. Orally bioavailable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro.
Baba et al.
Antiretroviral activity of stav. (2',3'-didehydro-3'-deoxythymidine, D4T).
Riddler et al.
Antiviral Res., 1995;27:189
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Stavudine triphosphate was studied to understand how it affects cellular synthesis of mitochondrial DNA.