Catalog Number: 4990
Chemical Name: 1-[(2R,5S)-2,5-Dihydro-5-(hydroxymethyl)-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
Biological Activity
Nucleoside analog; antiviral that inhibits HIV replication in vitro. Orally bioavailable.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro.
    Baba et al.
    Biochem.Biophys.Res.Commun., 1987;142:128
  2. Antiretroviral activity of stavudine (2',3'-didehydro-3'-deoxythymidine, D4T).
    Riddler et al.
    Antiviral Res., 1995;27:189
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