Chemical Name: 1-[(2R,5S)-2,5-Dihydro-5-(hydroxymethyl)-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
Biological ActivityStavudine is a nucleoside analog; antiviral that inhibits HIV replication in vitro. Orally bioavailable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro.
Baba et al.
Antiretroviral activity of stav. (2',3'-didehydro-3'-deoxythymidine, D4T).
Riddler et al.
Antiviral Res., 1995;27:189
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Stavudine triphosphate was studied to understand how it affects cellular synthesis of mitochondrial DNA.