Chemical Name: [3-[[4-(3-Ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethylsulfonium 4-methylbenzenesulfonate
Biological ActivitySuplatast tosylate is a th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN-γ production. Acts as an immunoregulator that suppresses IgE production, eosinophil infiltration and histamine release. Exhibits antiasthmatic, anti-inflammatory and antifibrotic activity in vivo and is orally active.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Suppressive effects of anti-allergic agent suplatast tosilate (IPD-1151T) on the expression of co-stimulatory molecules on mouse splenocytes in vivo.
Kurokawa et al.
Mediators Inflamm., 2001;10:333
The effects of suplatast tosilate (IPD-1151T) on innate immunity and antigen-presenting cells.
Hsu et al.
Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice.
Furonaka et al.
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