Catalog Number: 3543
Alternate Names: IPD 1151T
Chemical Name: [3-[[4-(3-Ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethylsulfonium 4-methylbenzenesulfonate
Biological Activity
Th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN-γ production. Acts as an immunoregulator that suppresses IgE production, eosinophil infiltration and histamine release. Exhibits antiasthmatic, anti-inflammatory and antifibrotic activity in vivo and is orally active.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Suppressive effects of anti-allergic agent suplatast tosilate (IPD-1151T) on the expression of co-stimulatory molecules on mouse splenocytes in vivo.
    Kurokawa et al.
    Mediators Inflamm., 2001;10:333
  2. The effects of suplatast tosilate (IPD-1151T) on innate immunity and antigen-presenting cells.
    Hsu et al.
    Transpl.Immunol., 2007;18:108
  3. Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice.
    Furonaka et al.
    J.Pharmacol.Exp.Ther., 2009;328:55
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