Non-selective P2 purinergic antagonist. Also blocks calmodulin binding to recognition sites and G protein coupling to G protein-coupled receptors. Increases open probability of ryanodine receptor (RyR) channels. Anticancer and antiviral agent.
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All Tocris products are intended for laboratory research use only.
Functional regulation of the cardiac ryanodine receptor by suramin and calmodulin involves multiple binding sites.
Hill et al.
PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors.
Charlton et al.
Inhibition of receptor/G protein coupling by suramin analogues.
Beindl et al.
Suramin and the suramin analogue NF307 discriminate among calmodulin-binding sites.
Klinger et al.
Recent research on the biological activity of suramin.
Voogd et al.
The citations listed below are publications that use Tocris products. Selected citations for Suramin hexasodium salt include:
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