Catalog Number: 1472
Chemical Name: 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Biological Activity
Non-selective P2 purinergic antagonist. Also blocks calmodulin binding to recognition sites and G protein coupling to G protein-coupled receptors. Increases open probability of ryanodine receptor (RyR) channels. Anticancer and antiviral agent.
Technical Data
  • M.Wt:
    1429.15
  • Formula:
    C51H34N6Na6O23S6
  • Solubility:
    Soluble to 50 mM in water and to 10 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    129-46-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Functional regulation of the cardiac ryanodine receptor by suramin and calmodulin involves multiple binding sites.
    Hill et al.
    Mol.Pharmacol., 2004;65:1258
  2. PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors.
    Charlton et al.
    Br.J.Pharmacol., 1996;118:704
  3. Inhibition of receptor/G protein coupling by suramin analogues.
    Beindl et al.
    Mol.Pharmacol., 1996;50:415
  4. Suramin and the suramin analogue NF307 discriminate among calmodulin-binding sites.
    Klinger et al.
    Biochem.J., 2001;355:827
  5. Recent research on the biological activity of suramin.
    Voogd et al.
    Pharmacol.Rev., 1993;45:177
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Suramin hexasodium salt include:

15 Citations: Showing 1 - 10
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  1. Role of purinergic signaling in experimental pneumococcal meningitis.
    Authors: Zierhut
    Sci Rep 2017;7:44625
  2. Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model.
    Authors: Naviaux Et al.
    Mol Autism 2015;6:1
  3. Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
    Authors: Rosa Et al.
    J Mol Neurosci 2015;4
  4. Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
    Authors: Tang Et al.
    J Neurosci 2015;35:3016
  5. Diadenosine tetraphosphate contributes to carbachol-induced tear secretion.
    Authors: Fonseca Et al.
    Purinergic Signal 2015;11:87
  6. Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy.
    Authors: Naviaux Et al.
    Transl Psychiatry 2014;4:e400
  7. Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model.
    Authors: Naviaux Et al.
    PLoS One 2013;8:e57380
  8. Neural progenitors organize in small-world networks to promote cell proliferation.
    Authors: Malmersjö Et al.
    J Pharmacol Exp Ther 2013;110:E1524
  9. ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation.
    Authors: Manohar Et al.
    J Leukoc Biol 2012;92:787
  10. Blockade of P2 nucleotide receptors after spinal cord injury reduced the gliotic response and spared tissue.
    Authors: Rodríguez-Zayas Et al.
    Am J Physiol Heart Circ Physiol 2012;46:167
  11. Purinergic receptors are required for HIV-1 infection of primary human macrophages.
    Authors: Hazleton Et al.
    J Immunol 2012;188:4488
  12. A high throughput scintillation proximity imaging assay for protein methyltransferases.
    Authors: Ibáñez Et al.
    Comb Chem High Throughput Screen 2012;15:359
  13. Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.
    Authors: Thrane Et al.
    Proc Natl Acad Sci U S A 2011;108:846
  14. Modulation of agonist binding to human dopamine receptor subtypes by L-prolyl-L-leucyl-glycinamide and a peptidomimetic analog.
    Authors: Verma Et al.
    Elife 2005;315:1228
  15. Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons.
    Authors: Price Et al.
    Br J Pharmacol 2004;142:257
Expand to show all 15 Citations

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