Suramin hexasodium salt

Tocris Bioscience | Catalog # 1472

Non-selective P2 antagonist
Tocris Bioscience

Key Product Details

Description

Non-selective P2 antagonist
View all P2X Receptor Antagonists »

Product Description

Suramin hexasodium salt is a non-selective P2 purinergic antagonist. Also blocks calmodulin binding to recognition sites and G protein coupling to G protein-coupled receptors. Increases open probability of ryanodine receptor (RyR) channels and acts as a competitive α1β2γ2 GABAA receptor antagonist. Anticancer, antiviral and antiparasitic agent.

This product may be supplied with a high degree of hydration and some residual NaCl, the amounts of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.

Product Specifications for Suramin hexasodium salt

Molecular Weight

1429.15

Formula

C51H34N6Na6O23S6

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt

CAS Number

129-46-4

PubChem ID

5360

InChI Key

VAPNKLKDKUDFHK-UHFFFAOYSA-H

SMILES

[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CC1=CC=C(C=C1NC(=O)C1=CC=CC(NC(=O)NC2=CC=CC(=C2)C(=O)NC2=C(C)C=CC(=C2)C(=O)NC2=C3C(C=C(C=C3S([O-])(=O)=O)S([O-])(=O)=O)=C(C=C2)S([O-])(=O)=O)=C1)C(=O)NC1=C2C(C=C(C=C2S([O-])(=O)=O)S([O-])(=O)=O)=C(C=C1)S([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 50 35
DMSO 5 4

Preparing Stock Solutions for Suramin hexasodium salt

The following data is based on the product molecular weight 1429.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.35 mM 2.00 mL 10.00 mL 19.99 mL
1.75 mM 0.40 mL 2.00 mL 4.00 mL
3.5 mM 0.20 mL 1.00 mL 2.00 mL
17.5 mM 0.04 mL 0.20 mL 0.40 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 45 publications citing the usage of this product.

Product Documents for Suramin hexasodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Suramin hexasodium salt

For research use only

Citations for Suramin hexasodium salt

Customer Reviews for Suramin hexasodium salt (3)

4.3 out of 5
3 Customer Ratings
5 Stars
33%
4 Stars
67%
3 Stars
0%
2 Stars
0%
1 Stars
0%

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  • good product, satisfied
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HuCCt1
    Verified Customer | Posted 06/10/2019
    The ATP induced expression of p-LKB1 was inhibited by Suramin in Cancer Cells.
    Suramin hexasodium salt 1472
  • P2 receptor antagonist
    Name: Karthik krishnamurthy
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: co-culture of neurons and astrocytes
    Verified Customer | Posted 11/08/2018
    50 micromolar of suramin was bath applied
    used to study synchronized calcium oscillations in co-cultures of neurons and glial cells
  • Non-selective P2X antagonist
    Name: Louis-Philippe Bernier
    Species: Mouse
    Assay Type: Ex Vivo
    Verified Customer | Posted 05/17/2018
    Non-specific P2X blocker, worked as expected.

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