Suramin hexasodium salt

  ( 19 citations )    
Product Datasheet
Catalog Number:1472
Chemical Name:8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
Product Details
Citations (19)
Reviews
Biological Activity
Non-selective P2 purinergic antagonist. Also blocks calmodulin binding to recognition sites and G protein coupling to G protein-coupled receptors. Increases open probability of ryanodine receptor (RyR) channels. Anticancer and antiviral agent.
Technical Data
  • M.Wt:
    1429.15
  • Formula:
    C51H34N6Na6O23S6
  • Solubility:
    Soluble to 50 mM in water and to 10 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    129-46-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Suramin hexasodium salt include:

19 Citations: Showing 1 - 10
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  1. Role of purinergic signaling in experimental pneumococcal meningitis.
    Authors: Zierhut
    Sci Rep  2017;7:44625
  2. Imaging extracellular ATP with a genetically-encoded, ratiometric fluorescent sensor.
    Authors: Conley
    PLoS One  2017;12(11):e0187481
  3. In vivo Calcium Imaging of Evoked Calcium Waves in the Embryonic Cortex.
    Authors: Yuryev Et al.
    Front Cell Neurosci  2016;9:500
  4. Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model.
    Authors: Naviaux Et al.
    Mol Autism  2015;6:1
  5. Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
    Authors: Rosa Et al.
    J Mol Neurosci  2015;4
  6. Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
    Authors: Tang Et al.
    J Neurosci  2015;35:3016
  7. Digoxin and adenosine triphosphate enhance the functional properties of tissue-engineered cartilage.
    Authors: Makris Et al.
    Tissue Eng Part A  2015;21:884
  8. The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate.
    Authors: Nishimura Et al.
    PLoS Pathog  2015;11:e1005184
  9. Diadenosine tetraphosphate contributes to carbachol-induced tear secretion.
    Authors: Fonseca Et al.
    Purinergic Signal  2015;11:87
  10. Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy.
    Authors: Naviaux Et al.
    Transl Psychiatry  2014;4:e400
  11. Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model.
    Authors: Naviaux Et al.
    PLoS One  2013;8:e57380
  12. Neural progenitors organize in small-world networks to promote cell proliferation.
    Authors: Malmersjö Et al.
    J Pharmacol Exp Ther  2013;110:E1524
  13. ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation.
    Authors: Manohar Et al.
    J Leukoc Biol  2012;92:787
  14. Blockade of P2 nucleotide receptors after spinal cord injury reduced the gliotic response and spared tissue.
    Authors: Rodríguez-Zayas Et al.
    Am J Physiol Heart Circ Physiol  2012;46:167
  15. Purinergic receptors are required for HIV-1 infection of primary human macrophages.
    Authors: Hazleton Et al.
    J Immunol  2012;188:4488
  16. A high throughput scintillation proximity imaging assay for protein methyltransferases.
    Authors: Ibáñez Et al.
    Comb Chem High Throughput Screen  2012;15:359
  17. Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.
    Authors: Thrane Et al.
    Proc Natl Acad Sci U S A  2011;108:846
  18. Modulation of agonist binding to human dopamine receptor subtypes by L-prolyl-L-leucyl-glycinamide and a peptidomimetic analog.
    Authors: Verma Et al.
    Elife  2005;315:1228
  19. Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons.
    Authors: Price Et al.
    Br J Pharmacol  2004;142:257
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