TACS-XL In Situ Apoptosis Detection Kit - TACS Blue Summary
• Robust method for in situ apoptosis detection
• Uses BrdU-based methods
• Precise cellular labeling
• Signal enhancing methods results in high signal-to-noise ratio
Why Use the TACS-XL In Situ Apoptosis Detection Kit - TACS Blue?
TACS•XL Blue Label Kit is designed for use with fixed frozen or paraffin embedded tissue sections. All the reagents required for the labeling and detection of fragmented DNA and to assist in the identification of apoptotic morphologies are provided including two permeabilization reagents, labeling and detection reagents, stop buffers, TACS Blue Label and Nuclear Fast Red counterstain as well as TACS-Nuclease for generating positive controls with your own samples.
TACS•XL Blue Label Kit is a complete kit for the in situ detection of DNA fragmentation. This modified TUNEL assay based kit on incorporation of bromodeoxyuridine (BrdU) at the 3’ OH ends of the DNA fragments that are formed during apoptosis and a specific antibody to BrdU resulting in a high signal-to-noise ratio and less sensitivity to protease-induced false positive labeling than digoxigenin or biotin-based kits.
• Proteinase K
• TACS-Blue Label™
• TACS-Nuclease Buffer
• Nuclear Fast Red
• TACS 2 TdT Labeling Buffer
• TACS 2 TdT Stop Buffer
• TdT Enzyme
• B-dNTP Mix
• anti-BrdU antibody
For research use only. Not for diagnositic use.
DNA Fragmentation in Mouse Lung Parenchyma Tissue Detected using the TACS XL® Blue Kit. Mouse lung parenchyma tissue was fixed and embedded in paraffin. Five micron sections were prepared and immobilized on slides. The tissue was labeled as describe in the TACS XL kit protocol (Catalog # 4828-30-BK) and analyzed by light microscopy for DNA fragmentation indicated by the blue stained cells. Data was provided courtesy of F. D'Agostini, University of Genova Via A. Pastore, Genova, Italy.
Citations for TACS-XL In Situ Apoptosis Detection Kit - TACS Blue
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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PCA-1/ALKBH3 contributes to pancreatic cancer by supporting apoptotic resistance and angiogenesis.
Authors: Yamato, Ichiro, Sho, Masayuki, Shimada, Keiji, Hotta, Kiyohiko, Ueda, Yuko, Yasuda, Satoshi, Shigi, Naoko, Konishi, Noboru, Tsujikawa, Kazutake, Nakajima, Yoshiyuk
Cancer Res, 2102;72(18):4829-39. 2102
Efficient Expression of HIV in Immunocompetent Mouse Brain Reveals a Novel Nonneurotoxic Viral Function in Hippocampal Synaptodendritic Injury and Memory Impairment
Authors: J Kelschenba, H He, BH Kim, A Borjabad, CJ Gu, W Chao, M Do, LR Sharer, H Zhang, O Arancio, MJ Potash, DJ Volsky
MBio, 2019;10(4):. 2019
Seminal plasma induces inflammation and enhances HIV-1 replication in human cervical tissue explants
Authors: A Introini, S Boström, F Bradley, A Gibbs, A Glaessgen, A Tjernlund, K Broliden
PLoS Pathog., 2017;13(5):e1006402. 2017
Interleukin-17 promotes prostate cancer via MMP7-induced epithelial-to-mesenchymal transition
Oncogene, 2016;0(0):. 2016
The Effect of Chronic Ozone Exposure on the Activation of Endoplasmic Reticulum Stress and Apoptosis in Rat Hippocampus
Authors: Selva Rivas-Aran
Front Aging Neurosci, 2016;8(0):245. 2016
Two Distinct Isoforms of Matrix Metalloproteinase-2 Are Associated with Human Delayed Kidney Graft Function.
Authors: Wanga S, Ceron C, Delgado C, Joshi S, Spaulding K, Walker J, Song S, Olson J, Lovett D
PLoS ONE, 2015;10(9):e0136276. 2015
Antiaging Gene Klotho Attenuates Pancreatic beta-Cell Apoptosis in Type 1 Diabetes.
Authors: Lin Y, Sun Z
Diabetes, 2015;64(12):4298-311. 2015
Influenza promotes collagen deposition via alphavbeta6 integrin-mediated transforming growth factor beta activation.
Authors: Jolly L, Stavrou A, Vanderstoken G, Meliopoulos V, Habgood A, Tatler A, Porte J, Knox A, Weinreb P, Violette S, Hussell T, Kolb M, Stampfli M, Schultz-Cherry S, Jenkins G
J Biol Chem, 2014;289(51):35246-63. 2014
Interleukin-17 promotes formation and growth of prostate adenocarcinoma in mouse models.
Authors: Zhang Q, Liu S, Ge D, Zhang Q, Xue Y, Xiong Z, Abdel-Mageed A, Myers L, Hill S, Rowan B, Sartor O, Melamed J, Chen Z, You Z
Cancer Res, 2012;72(10):2589-99. 2012
Ventricular preexcitation modulates strain and attenuates cardiac remodeling in a swine model of myocardial infarction.
Authors: Shuros AC, Salo RW, Florea VG, Pastore J, Kuskowski MA, Chandrashekhar Y, Anand IS
Circulation, 2007;116(10):1162-9. 2007
Lactate dehydrogenase-elevating virus induces apoptosis in cultured macrophages and in spinal cords of C58 mice coincident with onset of murine amyotrophic lateral sclerosis.
Authors: Zitterkopf NL, McNeal DW, Eyster KM, Bradley DS, Cafruny WA
Virus Res., 2004;106(1):35-42. 2004
Polyethylene glycol reduces the inflammatory injury due to cold ischemia/reperfusion in autotransplanted pig kidneys.
Authors: Hauet T, Goujon JM, Baumert H, Petit I, Carretier M, Eugene M, Vandewalle A
Kidney Int., 2002;62(2):654-67. 2002
Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7.
Authors: Zhang Y, Cross S, Stanton J, Marmorstein A, Le Y, Marmorstein L
Mol Vis, 0;23(0):228-241. 0
P450 inhibitor ketoconazole increased the intratumor drug levels and antitumor activity of fenretinide in human neuroblastoma xenograft models.
Authors: Lopez-Barcons L, Maurer B, Kang M, Reynolds C
Int J Cancer, 0;141(2):405-413. 0
Targeting Th17-IL-17 Pathway in Prevention of Micro-Invasive Prostate Cancer in a Mouse Model.
Authors: Zhang Q, Liu S, Ge D, Cunningham D, Huang F, Ma L, Burris T, You Z
Prostate, 0;77(8):888-899. 0
Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer.
Authors: Park J, Sarode V, Euhus D, Kittler R, Scherer P
Proc Natl Acad Sci U S A, 0;109(51):21058-63. 0
Calcium-sensing receptor and apoptosis in parathyroid hyperplasia of patients with secondary hyperparathyroidism.
Authors: Lee H, Seo U, Kim W, Woo S, Lee J
J Int Med Res, 0;41(1):97-105. 0
A lysigenic programmed cell death-dependent process shapes schizogenously formed aerenchyma in the stems of the waterweed Egeria densa.
Authors: Bartoli G, Forino L, Durante M, Tagliasacchi A
Ann Bot, 0;116(1):91-9. 0
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