TACS-XL In Situ Apoptosis Detection Kit - TACS Blue

Catalog # Availability Size / Price Qty
Mouse Lung Parenchyma Tissue_TACS XL In Situ Apoptosis Kit
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Product Details
Citations (21)

TACS-XL In Situ Apoptosis Detection Kit - TACS Blue Summary

Provides a complete kit for the in situ detection of DNA fragmentation.

Key Benefits

• Robust method for in situ apoptosis detection
• Uses BrdU-based methods
• Precise cellular labeling
• Signal enhancing methods results in high signal-to-noise ratio

Why Use the TACS-XL In Situ Apoptosis Detection Kit - TACS Blue?

TACS•XL Blue Label Kit is designed for use with fixed frozen or paraffin embedded tissue sections. All the reagents required for the labeling and detection of fragmented DNA and to assist in the identification of apoptotic morphologies are provided including two permeabilization reagents, labeling and detection reagents, stop buffers, TACS Blue Label and Nuclear Fast Red counterstain as well as TACS-Nuclease for generating positive controls with your own samples.

TACS•XL Blue Label Kit is a complete kit for the in situ detection of DNA fragmentation. This modified TUNEL assay based kit on incorporation of bromodeoxyuridine (BrdU) at the 3’ OH ends of the DNA fragments that are formed during apoptosis and a specific antibody to BrdU resulting in a high signal-to-noise ratio and less sensitivity to protease-induced false positive labeling than digoxigenin or biotin-based kits.

Kit Contents

• Proteinase K
• Streptavidin-HRP
• TACS-Blue Label™
• TACS-Nuclease
• TACS-Nuclease Buffer
• Nuclear Fast Red
• TACS 2 TdT Labeling Buffer
• TACS 2 TdT Stop Buffer
• TdT Enzyme
• B-dNTP Mix
• anti-BrdU antibody
• Strep-Diluent
• Cytonin


Shipping Conditions
The components for this kit may require different storage/shipping temperatures and may arrive in separate packaging. Upon receipt, store products immediately at the temperature recommended on the product labels.
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.


For research use only. Not for diagnostic use.

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Scientific Data

DNA Fragmentation in Mouse Lung Parenchyma Tissue Detected using the TACS XL® Blue Kit. Mouse lung parenchyma tissue was fixed and embedded in paraffin. Five micron sections were prepared and immobilized on slides. The tissue was labeled as describe in the TACS XL kit protocol (Catalog # 4828-30-BK) and analyzed by light microscopy for DNA fragmentation indicated by the blue stained cells. Data was provided courtesy of F. D'Agostini, University of Genova Via A. Pastore, Genova, Italy.

Citations for TACS-XL In Situ Apoptosis Detection Kit - TACS Blue

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

21 Citations: Showing 1 - 10
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  1. ZnT2 Is Critical for TLR4-Mediated Cytokine Expression in Colonocytes and Modulates Mucosal Inflammation in Mice
    Authors: K McGourty, R Vijayakuma, T Wu, A Gagnon, SL Kelleher
    International Journal of Molecular Sciences, 2022-09-28;23(19):.  2022-09-28
  2. Domestic cat hepadnavirus associated with hepatopathy in cats: A retrospective study
    Authors: C Piewbang, W Dankaona, P Poonsin, J Yostawonku, S Lacharoje, S Sirivisoot, T Kasantikul, P Tummaruk, S Techangams
    Journal of veterinary internal medicine, 2022-08-24;0(0):.  2022-08-24
  3. Mycobacterium avium subsp. hominissuis (MAH) Microaggregate induction of host innate immunity is linked to biofilm formation
    Authors: BF Keefe, A Leestemake, LE Bermudez
    Microbial pathogenesis, 2021-05-18;157(0):104977.  2021-05-18
  4. Efficient Expression of HIV in Immunocompetent Mouse Brain Reveals a Novel Nonneurotoxic Viral Function in Hippocampal Synaptodendritic Injury and Memory Impairment
    Authors: J Kelschenba, H He, BH Kim, A Borjabad, CJ Gu, W Chao, M Do, LR Sharer, H Zhang, O Arancio, MJ Potash, DJ Volsky
    MBio, 2019-07-02;10(4):.  2019-07-02
  5. Seminal plasma induces inflammation and enhances HIV-1 replication in human cervical tissue explants
    Authors: A Introini, S Boström, F Bradley, A Gibbs, A Glaessgen, A Tjernlund, K Broliden
    PLoS Pathog., 2017-05-19;13(5):e1006402.  2017-05-19
  6. P450 inhibitor ketoconazole increased the intratumor drug levels and antitumor activity of fenretinide in human neuroblastoma xenograft models.
    Authors: Lopez-Barcons L, Maurer B, Kang M, Reynolds C
    Int J Cancer, 2017-05-09;141(2):405-413.  2017-05-09
  7. Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7.
    Authors: Zhang Y, Cross S, Stanton J, Marmorstein A, Le Y, Marmorstein L
    Mol Vis, 2017-04-14;23(0):228-241.  2017-04-14
  8. Targeting Th17-IL-17 Pathway in Prevention of Micro-Invasive Prostate Cancer in a Mouse Model.
    Authors: Zhang Q, Liu S, Ge D, Cunningham D, Huang F, Ma L, Burris T, You Z
    Prostate, 2017-02-27;77(8):888-899.  2017-02-27
  9. The Effect of Chronic Ozone Exposure on the Activation of Endoplasmic Reticulum Stress and Apoptosis in Rat Hippocampus
    Authors: Selva Rivas-Aran
    Front Aging Neurosci, 2016-10-25;8(0):245.  2016-10-25
  10. Interleukin-17 promotes prostate cancer via MMP7-induced epithelial-to-mesenchymal transition
    Oncogene, 2016-07-04;0(0):.  2016-07-04
  11. Two Distinct Isoforms of Matrix Metalloproteinase-2 Are Associated with Human Delayed Kidney Graft Function.
    Authors: Wanga S, Ceron C, Delgado C, Joshi S, Spaulding K, Walker J, Song S, Olson J, Lovett D
    PLoS ONE, 2015-09-17;10(9):e0136276.  2015-09-17
  12. Antiaging Gene Klotho Attenuates Pancreatic beta-Cell Apoptosis in Type 1 Diabetes.
    Authors: Lin Y, Sun Z
    Diabetes, 2015-09-04;64(12):4298-311.  2015-09-04
  13. A lysigenic programmed cell death-dependent process shapes schizogenously formed aerenchyma in the stems of the waterweed Egeria densa.
    Authors: Bartoli G, Forino L, Durante M, Tagliasacchi A
    Ann Bot, 2015-05-22;116(1):91-9.  2015-05-22
  14. Influenza promotes collagen deposition via alphavbeta6 integrin-mediated transforming growth factor beta activation.
    Authors: Jolly L, Stavrou A, Vanderstoken G, Meliopoulos V, Habgood A, Tatler A, Porte J, Knox A, Weinreb P, Violette S, Hussell T, Kolb M, Stampfli M, Schultz-Cherry S, Jenkins G
    J Biol Chem, 2014-10-22;289(51):35246-63.  2014-10-22
  15. Calcium-sensing receptor and apoptosis in parathyroid hyperplasia of patients with secondary hyperparathyroidism.
    Authors: Lee H, Seo U, Kim W, Woo S, Lee J
    J Int Med Res, 2013-01-28;41(1):97-105.  2013-01-28
  16. Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer.
    Authors: Park J, Sarode V, Euhus D, Kittler R, Scherer P
    Proc Natl Acad Sci U S A, 2012-12-03;109(51):21058-63.  2012-12-03
  17. PCA-1/ALKBH3 contributes to pancreatic cancer by supporting apoptotic resistance and angiogenesis.
    Authors: Yamato, Ichiro, Sho, Masayuki, Shimada, Keiji, Hotta, Kiyohiko, Ueda, Yuko, Yasuda, Satoshi, Shigi, Naoko, Konishi, Noboru, Tsujikawa, Kazutake, Nakajima, Yoshiyuk
    Cancer Res, 2012-07-23;72(18):4829-39.  2012-07-23
  18. Interleukin-17 promotes formation and growth of prostate adenocarcinoma in mouse models.
    Authors: Zhang Q, Liu S, Ge D, Zhang Q, Xue Y, Xiong Z, Abdel-Mageed A, Myers L, Hill S, Rowan B, Sartor O, Melamed J, Chen Z, You Z
    Cancer Res, 2012-03-28;72(10):2589-99.  2012-03-28
  19. Ventricular preexcitation modulates strain and attenuates cardiac remodeling in a swine model of myocardial infarction.
    Authors: Shuros AC, Salo RW, Florea VG, Pastore J, Kuskowski MA, Chandrashekhar Y, Anand IS
    Circulation, 2007-08-20;116(10):1162-9.  2007-08-20
  20. Lactate dehydrogenase-elevating virus induces apoptosis in cultured macrophages and in spinal cords of C58 mice coincident with onset of murine amyotrophic lateral sclerosis.
    Authors: Zitterkopf NL, McNeal DW, Eyster KM, Bradley DS, Cafruny WA
    Virus Res., 2004-11-01;106(1):35-42.  2004-11-01
  21. Polyethylene glycol reduces the inflammatory injury due to cold ischemia/reperfusion in autotransplanted pig kidneys.
    Authors: Hauet T, Goujon JM, Baumert H, Petit I, Carretier M, Eugene M, Vandewalle A
    Kidney Int., 2002-08-01;62(2):654-67.  2002-08-01


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