Catalog Number: 6105
Chemical Name: 6-(1H-Indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid methyl ester
Biological Activity
High affinity BET bromodomain ligand (Kd values are 40 and 800 nM for Brd2(2) and Brd2(1), respectively). Exhibits 20-fold selectively for the second over the first bromodomain.
Technical Data
  • M.Wt:
    415.44
  • Formula:
    C23H21N5O3
  • Solubility:
    Soluble to 5 mM in DMSO with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    1809296-92-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under licence from the University of Dundee.
Background References
  1. New synthetic routes to triazolo-benzodiazepine analogues: expanding the scope of the bump-and-hole approach for selective bromo and extra-terminal (BET) bromodomain inhibition.
    Baud et al.
    J.Med.Chem., 2016;59:1492
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch:

Feedback

Customer Information