Biological ActivityProtein arginine deiminase 4 (PAD4) inhibitor (IC50 values are 2.3, 8.5, 26 and 71 μM for PAD4, PAD1, PAD3 and PAD2, respectively).
(Modifications: Thr-1 = N-terminal Ac, X = N5-(2-fluoro-1-iminoethyl)]-Orn), X-3= C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors.
Jones et al.
ACS Chem.Biol., 2012;7:160
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