Teijin compound 1
Chemical Name: N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide hydrochloride
Purity: ≥98%
Biological Activity
Teijin compound 1 is a potent chemokine CCR2b receptor antagonist (IC50 = 180 nM). Potently inhibits cell chemotaxis induced by MCP-1 (EC50 = 24 nM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5.
Hall et al.
Mol.Pharmacol., 2009;75:1325 -
Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series.
Moree et al.
Bioorg.Med.Chem.Letts., 2008;18:1869 -
Small molecule antagonists of the CCR2b receptor. Part 2: discovery process and initial structure-activity relationships of diamine derivatives.
Moree et al.
Bioorg.Med.Chem.Letts., 2004;14:5413
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