Teijin compound 1

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Teijin compound 1 | CAS No. 1313730-14-1 | Chemokine Receptor Antagonists
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Description: Potent CCR2b antagonist

Chemical Name: N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide hydrochloride

Purity: ≥98%

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Biological Activity

Potent chemokine CCR2b receptor antagonist (IC50 = 180 nM). Potently inhibits cell chemotaxis induced by MCP-1 (EC50 = 24 nM).

Technical Data

M.Wt:
476.32
Formula:
C21H21ClF3N3O2.HCl
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
1313730-14-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5.
    Hall et al.
    Mol.Pharmacol., 2009;75:1325
  2. Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series.
    Moree et al.
    Bioorg.Med.Chem.Letts., 2008;18:1869
  3. Small molecule antagonists of the CCR2b receptor. Part 2: discovery process and initial structure-activity relationships of diamine derivatives.
    Moree et al.
    Bioorg.Med.Chem.Letts., 2004;14:5413

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