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(-)-Terreic acid

Catalog #: 1405 Datasheet / COA / SDS

Discontinued Product

1405 has been discontinued.
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(-)-Terreic acid | CAS No. 121-40-4 | Brutons Tyrosine Kinase (BTK) Inhibitors
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Description: Selective inhibitor of BTK

Chemical Name: (1R,6S)-3-Hydroxy-4-methyl-7-oxabicyclo[4.1.0]hept-3-ene-2,5-dione

Purity: ≥99%

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Biological Activity

(-)-Terreic acid is a selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits the interaction between PKCbII and BTK (IC50 ~ 30 mM) and the catalytic activity of BTK but does not affect the activity of PKC. Has little effect on the activities of Lyn, Syk, PKA, casein kinase I, ERK1, ERK2 and p38 kinases.

Technical Data

M.Wt:
154.12
Formula:
C7H6O4
Solubility:
Soluble to 20 mM in water
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
121-40-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase.
    Kawakami et al.
    Proc.Natl.Acad.Sci.U.S.A., 1999;96:2227
  2. In vivo and in vitro studies on the binding nature of terreic acid with macromolecules such as protein and nucleic acids.
    Subramanian et al.
    Toxicol.Lett., 1982;10:249
  3. Studies on terreic acid.
    Yamamoto et al.
    Jpn.J.Antibiot., 1980;33:320

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