Catalog Number: 1405
Chemical Name: (1R,6S)-3-Hydroxy-4-methyl-7-oxabicyclo[4.1.0]hept-3-ene-2,5-dione
Biological Activity
Selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits the interaction between PKCbII and BTK (IC50 ~ 30 mM) and the catalytic activity of BTK but does not affect the activity of PKC. Has little effect on the activities of Lyn, Syk, PKA, casein kinase I, ERK1, ERK2 and p38 kinases.
Technical Data
  • M.Wt:
    154.12
  • Formula:
    C7H6O4
  • Solubility:
    Soluble to 20 mM in water
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    121-40-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase.
    Kawakami et al.
    Proc.Natl.Acad.Sci.U.S.A., 1999;96:2227
  2. Studies on terreic acid.
    Yamamoto et al.
    Jpn.J.Antibiot., 1980;33:320
  3. In vivo and in vitro studies on the binding nature of terreic acid with macromolecules such as protein and nucleic acids.
    Subramanian et al.
    Toxicol.Lett., 1982;10:249

Have you used (-)-Terreic acid?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information