Catalog Number: 1405
Chemical Name: (1R,6S)-3-Hydroxy-4-methyl-7-oxabicyclo[4.1.0]hept-3-ene-2,5-dione
Biological Activity
Selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits the interaction between PKCbII and BTK (IC50 ~ 30 mM) and the catalytic activity of BTK but does not affect the activity of PKC. Has little effect on the activities of Lyn, Syk, PKA, casein kinase I, ERK1, ERK2 and p38 kinases.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in water
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase.
    Kawakami et al.
    Proc.Natl.Acad.Sci.U.S.A., 1999;96:2227
  2. Studies on terreic acid.
    Yamamoto et al.
    Jpn.J.Antibiot., 1980;33:320
  3. In vivo and in vitro studies on the binding nature of terreic acid with macromolecules such as protein and nucleic acids.
    Subramanian et al.
    Toxicol.Lett., 1982;10:249
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