Tetrodotoxin citrate

  ( 42 citations )    
Product Datasheet
Catalog Number:1069
Alternate Names:TTx citrate
Chemical Name:Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol citrate
Product Details
Citations (42)
Supplemental Products
Reviews
Biological Activity
Highly selective, reversible sodium channel blocker; citrate salt of tetrodotoxin.
Technical Data
  • M.Wt:
    319.27
  • Formula:
    C11H17N3O8
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    18660-81-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Tetrodotoxin citrate include:

42 Citations: Showing 1 - 10
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  1. Optogenetic Modulation of Urinary Bladder Contraction for Lower Urinary Tract Dysfunction.
    Authors: Park Et al.
    Sci Rep  2017;7:40872
  2. The chemokine CXCL16 modulates neurotransmitter release in hippocampal CA1 area
    Authors: Di Castro Et al.
    Scientific Reports  2016;6:34633
  3. Transcriptomes of lineage-specific Drosophila neuroblasts profiled by genetic targeting and robotic sorting.
    Authors: Yang Et al.
    Development  2016;143:411
  4. Fixed single-cell transcriptomic characterization of human radial glial diversity.
    Authors: Thomsen Et al.
    Proc Natl Acad Sci U S A  2016;13:87
  5. Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.
    Authors: Angelantonio Et al.
    PLoS One  2015;9:409
  6. Fmrp targets or not: long, highly brain-expressed genes tend to be implicated in autism and brain disorders.
    Authors: Ouwenga and Dougherty
    Mol Autism  2015;6:16
  7. Branch-specific dendritic Ca(2+) spikes cause persistent synaptic plasticity.
    Authors: Cichon and Gan
    Nature  2015;520:180
  8. Sazetidine-A Activates and Desensitizes Native α7 Nicotinic Acetylcholine Receptors.
    Authors: Brown and Wonnacott
    Gastroenterology  2015;40:2047
  9. Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output.
    Authors: Liu Et al.
    J Neurophysiol  2015;35:5680
  10. The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4.
    Authors: Li Et al.
    J Neurosci  2015;35:13487
  11. Benchmarking the stability of human detergent-solubilised voltage-gated sodium channels for structural studies using eel as a reference.
    Authors: Slowik and Henderson
    J Neurosci  2015;1848:1545
  12. Direct visualization of newly synthesized target proteins in situ.
    Authors: Dieck Et al.
    Nat Methods  2015;12:411
  13. Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors.
    Authors: Tseng Et al.
    Front Cell Neurosci  2015;112:1214
  14. Assessment of TTX-s and TTX-r Action Potential Conduction along Neurites of NGF and GDNF Cultured Porcine DRG Somata.
    Authors: Jonas Et al.
    Neurochem Res  2015;10:e0139107
  15. Excitatory drive onto dopaminergic neurons in the rostral linear nucleus is enhanced by norepinephrine in an α1 adrenergic receptor-dependent manner.
    Authors: Williams Et al.
    Neuropharmacology  2014;86:116
  16. A novel mechanism for nicotinic potentiation of glutamatergic synapses.
    Authors: Halff Et al.
    J Neurosci  2014;34:2051
  17. Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium.
    Authors: Carneiro Et al.
    Br J Pharmacol  2014;171:3404
  18. Dynamic interactions mediated by nonredundant signaling mechanisms couple circadian clock neurons.
    Authors: Evans Et al.
    Neuron  2013;80:973
  19. The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition.
    Authors: Bloodgood Et al.
    Nature  2013;503:121
  20. Holographic optogenetic stimulation of patterned neuronal activity for vision restoration.
    Authors: Reutsky-Gefen Et al.
    Nat Methods  2013;4:1509
  21. Direct retino-raphe projection alters serotonergic tone and affective behavior.
    Authors: Ren Et al.
    Neuropsychopharmacology  2013;38:1163
  22. Mis-expression of the BK K(+) channel disrupts suprachiasmatic nucleus circuit rhythmicity and alters clock-controlled behavior.
    Authors: Montgomery Et al.
    Am J Physiol Cell Physiol  2013;304:C299
  23. SHANK3 gene mutations associated with autism facilitate ligand binding to the Shank3 ankyrin repeat region.
    Authors: Mameza Et al.
    Biochim Biophys Acta  2013;288:26697
  24. Optogenetic stimulation of the corticothalamic pathway affects relay cells and GABAergic neurons differently in the mouse visual thalamus.
    Authors: Jurgens Et al.
    PLoS One  2012;7:e45717
  25. A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation.
    Authors: Tozzi Et al.
    PLoS One  2012;7:e38312
  26. In vitro maturation of dopaminergic neurons derived from mouse embryonic stem cells: implications for transplantation.
    Authors: Watmuff Et al.
    J Neurosci  2012;7:e31999
  27. Retinal waves coordinate patterned activity throughout the developing visual system.
    Authors: Ackman Et al.
    Nature  2012;490:219
  28. Neuregulin directly decreases voltage-gated sodium current in hippocampal ErbB4-expressing interneurons.
    Authors: Janssen Et al.
    J Neurosci  2012;32:13889
  29. Increased bursting glutamatergic neurotransmission in an auditory forebrain area of the zebra finch (Taenopygia guttata) induced by auditory stimulation.
    Authors: Dagostin Et al.
    J Biol Chem  2012;198:705
  30. 5-hydroxytryptamine 2C receptors tonically augment synaptic currents in the nucleus tractus solitarii.
    Authors: Austgen Et al.
    PLoS One  2012;108:2292
  31. Tetrodotoxin sensitivity of the vertebrate cardiac Na+ current.
    Authors: Vornanen Et al.
    Mar Drugs  2011;9:2409
  32. Multiple arrhythmic syndromes in a newborn, owing to a novel mutation in SCN5A.
    Authors: Calloe Et al.
    Can J Physiol Pharmacol  2011;89:723
  33. Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen.
    Authors: Stacpoole Et al.
    Nat Protoc  2011;6:1229
  34. Regulation of glycine receptor diffusion properties and gephyrin interactions by protein kinase C.
    Authors: Specht Et al.
    EMBO J  2011;30:3842
  35. Characteristics of 5-hydroxytryptamine receptors involved in contraction of feline ileal longitudinal smooth muscle.
    Authors: Wang Et al.
    Korean J Physiol Pharmacol  2011;15:267
  36. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
    Authors: Zemkova Et al.
    Endocrinology  2011;152:3842
  37. Hydrogen sulfide augments synaptic neurotransmission in the nucleus of the solitary tract.
    Authors: Austgen Et al.
    Mol Brain  2011;106:1822
  38. A calcium-activated nonselective cation conductance underlies the plateau potential in rat substantia nigra GABAergic neurons.
    Authors: Lee and Tepper
    J Neurosci  2007;27:6531
  39. New transmembrane AMPA receptor regulatory protein isoform, γ-7, differentially regulates AMPA receptors.
    Authors: Kato Et al.
    J Comp Physiol A Neuroethol Sens Neural Behav Phys  2007;27:4969
  40. Dopaminergic modulation of spinal neuronal excitability.
    Authors: Han Et al.
    J Neurophysiol  2007;27:13192
  41. Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon.
    Authors: Khan Et al.
    Br J Pharmacol  2006;147:607
  42. Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon.
    Authors: Schicho Et al.
    J Neurosci  2006;131:1542
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