Tetrodotoxin citrate

  ( 42 citations )    
Product Datasheet
Catalog Number:1069
Alternate Names:TTx citrate
Chemical Name:Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol citrate
Product Details
Citations (42)
Supplemental Products
Biological Activity
Highly selective, reversible sodium channel blocker; citrate salt of tetrodotoxin.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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The citations listed below are publications that use Tocris products. Selected citations for Tetrodotoxin citrate include:

42 Citations: Showing 1 - 10
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  1. Optogenetic Modulation of Urinary Bladder Contraction for Lower Urinary Tract Dysfunction.
    Authors: Park Et al.
    Sci Rep  2017;7:40872
  2. The chemokine CXCL16 modulates neurotransmitter release in hippocampal CA1 area
    Authors: Di Castro Et al.
    Scientific Reports  2016;6:34633
  3. Transcriptomes of lineage-specific Drosophila neuroblasts profiled by genetic targeting and robotic sorting.
    Authors: Yang Et al.
    Development  2016;143:411
  4. Fixed single-cell transcriptomic characterization of human radial glial diversity.
    Authors: Thomsen Et al.
    Proc Natl Acad Sci U S A  2016;13:87
  5. Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.
    Authors: Angelantonio Et al.
    PLoS One  2015;9:409
  6. Fmrp targets or not: long, highly brain-expressed genes tend to be implicated in autism and brain disorders.
    Authors: Ouwenga and Dougherty
    Mol Autism  2015;6:16
  7. Branch-specific dendritic Ca(2+) spikes cause persistent synaptic plasticity.
    Authors: Cichon and Gan
    Nature  2015;520:180
  8. Sazetidine-A Activates and Desensitizes Native α7 Nicotinic Acetylcholine Receptors.
    Authors: Brown and Wonnacott
    Gastroenterology  2015;40:2047
  9. Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output.
    Authors: Liu Et al.
    J Neurophysiol  2015;35:5680
  10. The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4.
    Authors: Li Et al.
    J Neurosci  2015;35:13487
  11. Benchmarking the stability of human detergent-solubilised voltage-gated sodium channels for structural studies using eel as a reference.
    Authors: Slowik and Henderson
    J Neurosci  2015;1848:1545
  12. Direct visualization of newly synthesized target proteins in situ.
    Authors: Dieck Et al.
    Nat Methods  2015;12:411
  13. Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors.
    Authors: Tseng Et al.
    Front Cell Neurosci  2015;112:1214
  14. Assessment of TTX-s and TTX-r Action Potential Conduction along Neurites of NGF and GDNF Cultured Porcine DRG Somata.
    Authors: Jonas Et al.
    Neurochem Res  2015;10:e0139107
  15. Excitatory drive onto dopaminergic neurons in the rostral linear nucleus is enhanced by norepinephrine in an α1 adrenergic receptor-dependent manner.
    Authors: Williams Et al.
    Neuropharmacology  2014;86:116
  16. A novel mechanism for nicotinic potentiation of glutamatergic synapses.
    Authors: Halff Et al.
    J Neurosci  2014;34:2051
  17. Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium.
    Authors: Carneiro Et al.
    Br J Pharmacol  2014;171:3404
  18. Dynamic interactions mediated by nonredundant signaling mechanisms couple circadian clock neurons.
    Authors: Evans Et al.
    Neuron  2013;80:973
  19. The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition.
    Authors: Bloodgood Et al.
    Nature  2013;503:121
  20. Holographic optogenetic stimulation of patterned neuronal activity for vision restoration.
    Authors: Reutsky-Gefen Et al.
    Nat Methods  2013;4:1509
  21. Direct retino-raphe projection alters serotonergic tone and affective behavior.
    Authors: Ren Et al.
    Neuropsychopharmacology  2013;38:1163
  22. Mis-expression of the BK K(+) channel disrupts suprachiasmatic nucleus circuit rhythmicity and alters clock-controlled behavior.
    Authors: Montgomery Et al.
    Am J Physiol Cell Physiol  2013;304:C299
  23. SHANK3 gene mutations associated with autism facilitate ligand binding to the Shank3 ankyrin repeat region.
    Authors: Mameza Et al.
    Biochim Biophys Acta  2013;288:26697
  24. Optogenetic stimulation of the corticothalamic pathway affects relay cells and GABAergic neurons differently in the mouse visual thalamus.
    Authors: Jurgens Et al.
    PLoS One  2012;7:e45717
  25. A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation.
    Authors: Tozzi Et al.
    PLoS One  2012;7:e38312
  26. In vitro maturation of dopaminergic neurons derived from mouse embryonic stem cells: implications for transplantation.
    Authors: Watmuff Et al.
    J Neurosci  2012;7:e31999
  27. Retinal waves coordinate patterned activity throughout the developing visual system.
    Authors: Ackman Et al.
    Nature  2012;490:219
  28. Neuregulin directly decreases voltage-gated sodium current in hippocampal ErbB4-expressing interneurons.
    Authors: Janssen Et al.
    J Neurosci  2012;32:13889
  29. Increased bursting glutamatergic neurotransmission in an auditory forebrain area of the zebra finch (Taenopygia guttata) induced by auditory stimulation.
    Authors: Dagostin Et al.
    J Biol Chem  2012;198:705
  30. 5-hydroxytryptamine 2C receptors tonically augment synaptic currents in the nucleus tractus solitarii.
    Authors: Austgen Et al.
    PLoS One  2012;108:2292
  31. Tetrodotoxin sensitivity of the vertebrate cardiac Na+ current.
    Authors: Vornanen Et al.
    Mar Drugs  2011;9:2409
  32. Multiple arrhythmic syndromes in a newborn, owing to a novel mutation in SCN5A.
    Authors: Calloe Et al.
    Can J Physiol Pharmacol  2011;89:723
  33. Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen.
    Authors: Stacpoole Et al.
    Nat Protoc  2011;6:1229
  34. Regulation of glycine receptor diffusion properties and gephyrin interactions by protein kinase C.
    Authors: Specht Et al.
    EMBO J  2011;30:3842
  35. Characteristics of 5-hydroxytryptamine receptors involved in contraction of feline ileal longitudinal smooth muscle.
    Authors: Wang Et al.
    Korean J Physiol Pharmacol  2011;15:267
  36. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
    Authors: Zemkova Et al.
    Endocrinology  2011;152:3842
  37. Hydrogen sulfide augments synaptic neurotransmission in the nucleus of the solitary tract.
    Authors: Austgen Et al.
    Mol Brain  2011;106:1822
  38. A calcium-activated nonselective cation conductance underlies the plateau potential in rat substantia nigra GABAergic neurons.
    Authors: Lee and Tepper
    J Neurosci  2007;27:6531
  39. New transmembrane AMPA receptor regulatory protein isoform, γ-7, differentially regulates AMPA receptors.
    Authors: Kato Et al.
    J Comp Physiol A Neuroethol Sens Neural Behav Phys  2007;27:4969
  40. Dopaminergic modulation of spinal neuronal excitability.
    Authors: Han Et al.
    J Neurophysiol  2007;27:13192
  41. Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon.
    Authors: Khan Et al.
    Br J Pharmacol  2006;147:607
  42. Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon.
    Authors: Schicho Et al.
    J Neurosci  2006;131:1542
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