Tetrodotoxin citrate

Tocris Bioscience | Catalog # 1069

Na+ channel blocker; citrate salt of tetrodotoxin (Cat. No. 1078)
Tocris Bioscience

Key Product Details

Description

Na+ channel blocker; citrate salt of tetrodotoxin (Cat. No. 1078)

Alternative Names

TTx citrate
View all Voltage-gated Sodium Channel Blockers »

Product Description

Tetrodotoxin citrate, the water-soluble citrate salt of tetrodotoxin, is a reversible, potent, selective and high affinity inhibitor of voltage gated sodium channels Nav 1.6, 1.1, 1.3, 1.4, 1.2 and 1.7 (IC50 values are 2.3 nM, 4.1 nM, 5.3 nM, 7.6 nM, 14 nM and 36 nM, respectively). Binding is reversible and high affinity (Kd = 1-10 nM). Tetrodotoxin shows antagonism of aconitine-induced cardiac toxicity, analgesic effects in mouse models of neuropathy and prolonged duration of local anesthesia in animals when combined with capsaicin. Tetrodotoxin also shows pH-dependent blockade of canine cardiac L-type Ca2+ (Cav1.x) channels, blocks primary reward in an animal study of drug-seeking lever pressing.

Tetrodotoxin (Cat. No. 1078) also available.

Product Specifications for Tetrodotoxin citrate

Molecular Weight

319.27

Formula

C11H17N3O8

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol citrate

CAS Number

18660-81-6

PubChem ID

16759596

InChI Key

CFMYXEVWODSLAX-CKYAAQHSSA-N

SMILES

OC1(CO)[C@H](O4)C(O)[C@@]2([C@@H]([C@@H](O)N3)C1O[C@](O)4[C@H]2O)NC3=N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 3.19 10

Preparing Stock Solutions for Tetrodotoxin citrate

The following data is based on the product molecular weight 319.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.32 mL 156.61 mL 313.21 mL
0.5 mM 6.26 mL 31.32 mL 62.64 mL
1 mM 3.13 mL 15.66 mL 31.32 mL
5 mM 0.63 mL 3.13 mL 6.26 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 510 publications citing the usage of this product.

Product Documents for Tetrodotoxin citrate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Tetrodotoxin citrate

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for Tetrodotoxin citrate

Customer Reviews for Tetrodotoxin citrate (3)

4.3 out of 5
3 Customer Ratings
5 Stars
33%
4 Stars
67%
3 Stars
0%
2 Stars
0%
1 Stars
0%

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  • homeostatic plasticity
    Name: Vineet Arora
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: Organotypic cultures
    Verified Customer | Posted 11/19/2020
    For studying homeostatic plasticity
  • Antidepressantsby Cholecystokinin Neurons of the Dentate Gyrus
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 02/03/2020
    10uM TTX
    Tetrodotoxin citrate 1069
  • blocks calcium oscillations well
    Name: Karthik krishnamurthy
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: hippocampal neurons
    Verified Customer | Posted 11/08/2018
    20 nM was used
    used to block calcium oscillations in neurons
    Tetrodotoxin citrate 1069

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