TG 100713
Chemical Name: 3-(2,4-Diamino-6-pteridinyl)-phenol
Purity: ≥98%
Biological Activity
Inhibitor of PI3-kinase (IC50 values are 24, 50, 165 and 215 nM for PI3Kδ, γ, α and β isoforms respectively). Inhibits endothelial cell proliferation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Phosphoinositide 3-kinase γ/δ inhibition limits infarct size after myocardial ischemia/reperfusion injury.
Doukas et al.
Proc.Natl.Acad.Sci.USA, 2006;103:19866 -
Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction.
Palanki et al.
J.Med.Chem., 2007;50:4279
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The effect of the compound was tested on the synaptic activity of cultured mouse neurons using electrophysiology
