Chemical Name: 3-(2,4-Diamino-6-pteridinyl)-phenol
Biological ActivityInhibitor of PI3-kinase (IC50 values are 24, 50, 165 and 215 nM for PI3Kδ, γ, α and β isoforms respectively). Inhibits endothelial cell proliferation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Phosphoinositide 3-kinase γ/δ inhibition limits infarct size after myocardial ischemia/reperfusion injury.
Doukas et al.
Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction.
Palanki et al.
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The effect of the compound was tested on the synaptic activity of cultured mouse neurons using electrophysiology