Inhibitor of PI3-kinase (IC50
values are 24, 50, 165 and 215 nM for PI3Kδ
isoforms respectively). Inhibits endothelial cell proliferation.
Soluble to 10 mM in DMSO
Desiccate at RT
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All Tocris products are intended for laboratory research use only.
Phosphoinositide 3-kinase γ/δ inhibition limits infarct size after myocardial ischemia/reperfusion injury.
Doukas et al.
Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction.
Palanki et al.