Catalog Number: 4264
Chemical Name: 3-(2,4-Diamino-6-pteridinyl)-phenol
Biological Activity
Inhibitor of PI3-kinase (IC50 values are 24, 50, 165 and 215 nM for PI3Kδ, γ, α and β isoforms respectively). Inhibits endothelial cell proliferation.
Technical Data
  • M.Wt:
    254.25
  • Formula:
    C12H10N6O
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    925705-73-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Phosphoinositide 3-kinase γ/δ inhibition limits infarct size after myocardial ischemia/reperfusion injury.
    Doukas et al.
    Proc.Natl.Acad.Sci.USA, 2006;103:19866
  2. Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction.
    Palanki et al.
    J.Med.Chem., 2007;50:4279

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