TGF-beta 2 Antibody (771213) [Janelia Fluor® 549]

Name: TGF-beta 2 Antibody (771213) [Janelia Fluor® 549]
Brand: Novus Biologicals
SKU: FAB7346I
Price: 559 USD
Availability: InStock

Novus Biologicals | Catalog # FAB7346I

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Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Mouse

Applications

Neutralization

Label

Janelia Fluor 549

Antibody Source

Monoclonal Rat IgG_2B Clone # 771213

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Product Specifications

Immunogen

Chinese hamster ovary cell line CHO-derived recombinant mouse TGF‑ beta 2
Ala303-Ser414
Accession # P27090

Specificity

Detects mouse TGF‑ beta 2 in direct ELISAs. In direct ELISAs, approximately 50% cross-reactivity with recombinant human (rh) TGF-beta 2 and rhTGF-beta 3 is observed.

Clonality

Monoclonal

Host

Rat

Isotype

IgG_2B

Applications for TGF-beta 2 Antibody (771213) [Janelia Fluor® 549]

Application

Recommended Usage

Neutralization

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: TGF-beta 2

Transforming Growth Factor (TGF) betas mediate many cell to cell interactions that occur during embryonic development. Three TGF betas have been identified in mammals. TGF beta 1, TGF beta 2 and TGF beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule. The TGF beta polypeptides are multifunctional; capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. Transformed, as well as nonneoplastic tissues, release transforming growth factors; and essentially all mammalian cells possess a specific TGF receptor. The multi modal nature of TGF beta is seen in its ability to stimulate or inhibit cellular proliferation. In general, cells of mesenchymal origin appear to be stimulated by TGF beta whereas cells of epithelial or neuroectodermal origin are inhibited by the peptide. TGF beta 1, TGF beta 2, and TGF beta 1.2 appear to be equivalent in biological activity, although there does appear to be differences in binding to certain types of receptors. TGF beta 2 is produced by many cell types and has been found in the highest concentration in porcine platelets and mammalian bone. Latent TGF beta 2 is the prominent isoform found in body fluids such as amniotic fluid, breast milk, and the aqueous and vitreous humor of the eye.

Long Name

Transforming Growth Factor beta 2

Alternate Names

TGFB2, TGFbeta 2

Gene Symbol

TGFB2

Additional TGF-beta 2 Products

Product Documents for TGF-beta 2 Antibody (771213) [Janelia Fluor® 549]

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Certificate of Analysis

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Product Specific Notices for TGF-beta 2 Antibody (771213) [Janelia Fluor® 549]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.