Thiazovivin

Catalog # Availability Size / Price Qty
3845/10
Thiazovivin | CAS No. 1226056-71-8 | Stem Cell Signaling Compounds
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Description: ROCK inhibitor; improves the efficiency of fibroblast reprogramming and induction of iPSCs

Chemical Name: N-Benzyl-[2-(pyrimidin-4-yl)amino]thiazole-4-carboxamide

Purity: ≥98%

Product Details
Citations (16)
Reviews

Biological Activity

Thiazovivin is a selective, cell-permeable Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor (IC50 = 0.5 μM). Thiazovivin enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614) and PD 0325901 (Cat. No. 4192). Thiazovivin improves the survival of human embryonic stem cells (hESCs) upon trypsinization and increases cell adhesion through the regulation of E-cadherin and significantly improves direct reprogramming efficiency. In combination with Valproic acid, sodium salt (Cat. No. 2815), Purmorphamine (Cat. No. 4551) and A 83-01 (Cat. No. 2939), Thiazovivin can be used to directly reprogram mouse embryonic fibroblasts into chemically induced neural stem cells.

Technical Data

M.Wt:
311.36
Formula:
C15H13N5OS
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1226056-71-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Thiazovivin

The citations listed below are publications that use Tocris products. Selected citations for Thiazovivin include:

16 Citations: Showing 1 - 10

  1. Step-by-step protocols for non-viral derivation of transgene-free induced pluripotent stem cells from somatic fibroblasts of multiple mammalian species.
    Authors: Toshiaki Et al.
    Dev Growth Differ  2022;64:325-341
  2. Krüppel-like factor 5 rewires NANOG regulatory network to activate human naive pluripotency specific LTR7Ys and promote naive pluripotency.
    Authors: Jia-Jie Et al.
    Cell Rep  2022;40:111240
  3. Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells.
    Authors: Mansa Et al.
    Cell Stem Cell  2022;29:36-51.e6
  4. Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems.
    Authors: Lu Et al.
    Nat Protoc  2022;17:2699-2719
  5. Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases.
    Authors: Kirsten Et al.
    Sci Adv  2021;7
  6. Patch-clamp and multi-electrode array electrophysiological analysis in acute mouse brain slices.
    Authors: Douglas G Et al.
    STAR Protoc  2021;2:100442
  7. Clostridioides difficile-Associated Antibiotics Alter Human Mucosal Barrier Functions by Microbiome-Independent Mechanisms.
    Authors: Douglas A Et al.
    Antimicrob Agents Chemother  2020;64
  8. Xeno-Free Reprogramming of Peripheral Blood Mononuclear Erythroblasts on Laminin-521.
    Authors: Yang Et al.
    Curr Protoc Stem Cell Biol  2020;52:e103
  9. Spatially controlled stem cell differentiation via morphogen gradients: A comparison of static and dynamic microfluidic platforms.
    Authors: Alexander R Et al.
    J Vac Sci Technol A  2020;38:033205
  10. Differential gene expression elicited by ZIKV infection in trophoblasts from congenital Zika syndrome discordant twins.
    Authors: Mayana Et al.
    PLoS Negl Trop Dis  2020;14:e0008424

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