Chemical Name: N-Benzyl-[2-(pyrimidin-4-yl)amino]thiazole-4-carboxamide
Biological ActivityThiazovivin is a selective, cell-permeable Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor (IC50 = 0.5 μM). Thiazovivin enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614) and PD 0325901 (Cat. No. 4192). Thiazovivin improves the survival of human embryonic stem cells (hESCs) upon trypsinization and increases cell adhesion through the regulation of E-cadherin and significantly improves direct reprogramming efficiency. In combination with Valproic acid, sodium salt (Cat. No. 2815), Purmorphamine (Cat. No. 4551) and A 83-01 (Cat. No. 2939), Thiazovivin can be used to directly reprogram mouse embryonic fibroblasts into chemically induced neural stem cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A chemical platform for improved induction of human iPSCs.
Lin et al.
Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules.
Xu et al.
Citations for Thiazovivin
The citations listed below are publications that use Tocris products. Selected citations for Thiazovivin include:
5 Citations: Showing 1 - 5
Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.
Nat Commun 2018;9(1):475
Derivation and characterization of the NIH registry human stem cell line NYSCF101 under defined feeder-free conditions.
Authors: Sevilla Et al.
Stem Cell Res 2018;29:197
Identification of direct negative cross-talk between the SLIT2 and bone morphogenetic protein-Gremlin signaling pathways.
Authors: Tumelty Et al.
J Biol Chem 2018;293:3039
Live imaging reveals that the first division of differentiating human embryonic stem cells often yields asymmetric fates.
Cell Rep 2017;21(2):301
Wnt/β-catenin signaling promotes self-renewal and inhibits the primed state transition in na�ve human embryonic stem cells.
Authors: Xu Et al.
Proc Natl Acad Sci U S A 2016;113:E6382
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